Monosodium Iodoacetate
Adelmidrol, in combination with hyaluronic acid, displays increased anti inflammatory and analgesic effects against monosodium iodoacetate induced osteoarthritis in rats
... The monosodium iodoacetate (MIA) experimental model is commonly used as an animal model of arthritis pain associated with OA [7]. In particular, the MIA model has been widely used for the pharmacological ...
12
“Ameliorating Effects of D-002, A Mixture of Beeswax Alcohols, on Monosodium Iodoacetate-Induced Osteoarthritis In Rats” by Sarahi Mendoza, Miriam Noa, Maikel Valle, Nilda Mendoza, Rosa Mas, Cuba. Digital copy link
... Osteoarthritis (OA) is characterized by degeneration, pain and inflammation of joint cartilage. The effects of D-002, a mixture of beeswax alcohols with anti-inflammatory action, on monosodium iodoacetate ...
6
Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain
... of monosodium iodoacetate (MIA, 1 mg) into the left knee, Sprague Dawley rats were anesthetized for functional magnetic resonance imaging studies to characterize the neural response to a noxious stimulus ...
12
Application of in vivo micro computed tomography in the temporal characterisation of subchondral bone architecture in a rat model of low dose monosodium iodoacetate induced osteoarthritis
... The monosodium iodoacetate (MIA)-induced OA rat model is a minimally invasive animal model that repro- duces cartilage and bone pathology similar to human OA ...
14
Antinociceptive efficacy of lacosamide in the monosodium iodoacetate rat model for osteoarthritis pain
... The etiology of osteoarthritis is multifactorial, with inflammatory, metabolic, and mechanical causes. Pain in osteoarthritis is initiated by mild intra-articular inflammation and degeneration of articular cartilage and ...
8
Psoralen Protects Chondrocytes, Exhibits Anti-Inflammatory Effects on Synoviocytes, and Attenuates Monosodium Iodoacetate-Induced Osteoarthritis
... of monosodium iodoacetate (MIA) induced OA model were used in order to assess the effects of PSO on attenuating degeneration of the articular cartilage in ...
10
Spinacia oleracea extract attenuates disease progression and sub chondral bone changes in monosodium iodoacetate induced osteoarthritis in rats
... 6B; Col10: Collagen type 10; Col2: Collagen type-II; COMP: Cartilage oligomeric matrix protein; CTX-II: C-telopeptide of type II collagen; GSTs: Glutathione S-transferases; IL-1β: Interl[r] ...
16
Effects of intra-articular SHINBARO treatment on monosodium iodoacetate-induced osteoarthritis in rats
... The protein levels of TNF-α and IL-1β revealed overexpression in the MIA-treated group compared with the control group, while IAS treatment suppressed the elevated expression levels o[r] ...
10
Cartilage protective and anti analgesic effects of ALM16 on monosodium iodoacetate induced osteoarthritis in rats
... This study demonstrated these properties using IL-1βinduced chondrocytes and an MIA-induced OA animal model, and the results showed that ALM16 significantly reduced pain, paw edema and O[r] ...
15
Concurrent validity of different functional and neuroproteomic pain assessment methods in the rat osteoarthritis monosodium iodoacetate (MIA) model
... Animals were tested on each of six assessment days by two observers, with the following methods in this order of evaluation: mechanical and tactile sensitivity, SWB, treadmill exercise, [r] ...
16
Morin Attenuates Interleukin-1 beta-Induced Inflammatory Response in Primary Rat Chondrocytes by Suppressing the Overproduction of Nitric Oxide and Matrix Metalloproteinases
... in monosodium iodoacetate- induced osteoarthritis in mice, it was found that morin at 25 and 50 mg/kg, significantly reduced the heat hyperalgesia and increased the spontaneous motility in mice on days 7, ...
7
Original Article Chondroprotective effect of galantamine: a natural alkaloid in osteoarthritis
... in monosodium iodoacetate induced osteoarthri- tis ...that monosodium iodo- acetate induces osteoarthritis rats resulted in swelling in joints and difficulty in walking ...
6
Predictable Peptide Conjugation Ratios by Activation of Proteins with Succinimidyl Iodoacetate (SIA)
... succinimidyl iodoacetate (SIA) was examined for the preparation of peptide–protein bioconjugates with predicable conjugation ...succinimidyl iodoacetate (SIA) in more detail and developed two protocols, ...
14
TOXICOLOGICAL STUDIES OF MONOSODIUM GLUTAMATE- A FOOD ADDITIVE
... of monosodium glutamate mostly on human lymophocytes and ...that monosodium glutamate induced chromosomal aberration and micronuclei formation in a dose dependant ...that monosodium glutamate is safe ...
14
The interaction of monosodium urate with connective tissue components
... Monosodium urate deposits almost exclusively in the connective tissues of patients with gout. Acetone dried homogenates of bovine nasal cartilage, but not of other tissues, markedly enhances the solubility of ...
8
Release of platelet constituents by monosodium urate crystals
... The release of human platelet constituents by the etiologic agent of gout, the monosodium urate crystal, is described here. In suspensions of washed platelets, response to urate crystals proceeded in two phases: A ...
10
Journal of Applied Pharmaceutical Science
... The administration of monosodium glutamate to newborn rats causes the destruction of the ventromedial hypothalamic and arcuate nuclei, leading the rats to develop obesity[r] ...
8
Intra articular injection of mono iodoacetate induces osteoarthritis of the hip in rats
... However, the mechanism for hip pain has been un- clear because of a lack of experimental animal models. For knee OA, several animal models have been proposed, such as the anterior cruciate ligament transection model [8], ...
7
The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3 bromopyruvate, iodoacetate or 5 fluorouracil
... Remarkably, down-regulation of b-F1-ATPase has been widely associated with the resistance of cancer cells to standard anticancer therapies [21-23]. In the specific case of colon cancer cells, chemotherapeutic response to ...
9
Volume 1 | Issue 2 - 2011
... Obesity is a pathological condition in with excess body fat. It is a chronic disorder with complex interaction between genetic and environmental factors. It is being characterized by high cholesterol, fatty acid levels, ...
13