Morphine Tolerance
Effect Of Dihydroxy Flavones On Morphine Tolerance
... of tolerance to morphine antinociception in ...to morphine injection every ...of morphine (1 mg/kg, ...with morphine for five days resulted in decrement of analgesic response on the ...
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Effect of sub-effective dose of GABA agonists on attenuation of morphine tolerance in rats: Behavioral and electrophysiological studies
... the morphine tolerance model, it is suggested that more molecular and electrophysiological studies on different types of morphine tolerance and in different sections and level of the spinal ...
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Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation
... attenuated morphine tolerance in a dose-dependent manner ...attenuated morphine tolerance ...chronically morphine-treated mice on day ...acute morphine analgesic effect ...
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Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia
... The function of NLRP3 inflammasome is crucial for the regulation of neuroinflammation mediated by microglia [19]. Therefore, compounds that inhibit the activation of NLRP3 inflammasome may contribute to the improvement ...
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Opioid receptor–triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia
... chronic morphine tolerance and ...to morphine leads to activation of astrocytes and microglia, increases in expression of various signaling receptors in their bodies, and release of proinflammatory ...
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GABA Agonists could Decrease Hyperalgesia and NO Serum Level in Morphine Tolerance Model
... in Morphine tolerance and NO synthase inhibitors can attenuate hyperalgesia in morphine ...in morphine tolerance is reduction of GABA inhibitory ...of morphine and NO level of ...
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Lidocaine alleviates morphine tolerance via AMPK-SOCS3-dependent neuroinflammation suppression in the spinal cord
... acute morphine analgesia effect and improve morphine tolerance with a mechanism of inhibiting neuroinflammation ...of morphine tolerance with lidocaine and lay the groundwork for ...
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Effect of L- Arginine, the Nitric Oxide Precursor, on Morphine Tolerance in Ovariectomized Rats
... on morphine tolerance in ovariectomized rats was ...groups. Morphine tolerance was induced by daily injection of 20 mg/kg morphine during 4 consecutive ...mg/kg morphine and ...
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MicroRNA-93-5p may participate in the formation of morphine tolerance in bone cancer pain mouse model by targeting Smad5
... the morphine model had a significantly higher miR-93 expression and a lower Smad5 expression than the other ...dose morphine fails to produce the analgesic effect as it did at the very ...addition, ...
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<p>Emerging roles of microRNAs in morphine tolerance</p>
... Chronic morphine exposure often results in increased expres- sion of various proin fl ammatory cytokines such as IL-1 β , IL-6, and TNF- α , in vitro and in vivo and elevates lipopolysacchar- ide (LPS)-induced ...
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Metformin reduces morphine tolerance by inhibiting microglial-mediated neuroinflammation
... in morphine tolerance ...attenuate morphine-induced pro- inflammatory cytokines production and inhibit morphine tolerance [38, ...that morphine increased p38 MAPK ...
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Original Article Intrathecal administration of dexmedetomidine attenuates the development of morphine tolerance via suppression of HMGB1-mediated neuro-inflammation in the spinal cord
... reduce morphine consumption without caus- ing serious side effects ...of morphine, as indi- cated by the tail-flick test, over the seven-day observation ...analgesic tolerance to morphine and ...
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Aripiprazole Prolongs Morphine Antinociception Effect and Disrupts Acute Morphine Tolerance
... acute morphine tolerance, mice were given morphine (100 mg/kg ...2006a). Tolerance to morphine developed within hours and peaked at approximately 4 to 6 h (Shukla et ...2006). ...
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Morphine-Induced Analgesic Tolerance Effect on Gene Expression of the NMDA Receptor Subunit 1 in Rat Striatum and Prefrontal Cortex
... after morphine tolerance increased in the striatum but decreased in the ...with morphine analgesic tol- erance. It is possible that long-term morphine treatment, via changes in concentrations ...
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Upregulation of miR-375 level ameliorates morphine analgesic tolerance in mouse dorsal root ganglia by inhibiting the JAK2/STAT3 pathway
... between morphine tolerance and ...after morphine treatment, and that blocking the JAK2/STAT3 pathway could attenu- ate the inhibitory effects of miR-375 antagomir on BDNF expression, proving that ...
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MicroRNA-365 alleviates morphine analgesic tolerance via the inactivation of the ERK/CREB signaling pathway by negatively targeting β-arrestin2
... Background: Morphine is widely used in clinical practice for a class of analgesic drugs, long-term use of morphine will cause the action of ...in morphine analgesic ...group, morphine ...
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Sonic hedgehog signaling in spinal cord contributes to morphine-induced hyperalgesia and tolerance through upregulating brain-derived neurotrophic factor expression
... of tolerance (Figure 5G) and MIH (Figure ...during morphine tolerance, immunofluorescence double staining was used to investigate the location of ...
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VITEX AGNUS-CASTUS FRUIT EXTRACT RESTRAINS ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED TOLERANCE IN MICE
... on morphine tolerance but more investigations are needed to elucidate the precise ...with morphine which can produce therapeutic analgesia with lower dose of morphine would be of great ...
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Sex differences in tolerance to morphine antinociception in intra-nucleus accumbens administration in rat
... and morphine antinociceptive effect and morphine tolerance in exploring the role of sex ...used, morphine induced more antinociceptive effects in both male mice and rats, compared to female ...
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Effects of glucosamine against morphine-induced antinociceptive tolerance and dependence in mice
... especially morphine, are the most widely used drugs in the treatment of acute and chronic pain, such as cancerous ...Pharmacological tolerance is one of the most common side effects of morphine ...
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