mossy fiber
Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca++ dysregulation
... the mossy fiber bouton ...the mossy fiber pathway implies a physiological role of Tau as a regulator of neuronal excitability at the DG-CA3 ...
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Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways
... (TNT2) and AT8 pathological changes occur early in disease progression, in post-mortem human tissue stud- ies we cannot rule out the possibility that the tau depos- ition here is independent of a progressive condition ...
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Action potential counting at giant mossy fiber terminals gates information transfer in the hippocampus
... mossy fiber stimulation (Fig. 1 B–D). The probability of ob- serving the first postsynaptic spike sharply increased at the sixth stimuli (Fig. 1E). Both the probability of CA3 pyramidal cell firing at the ...
7
Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway
... the mossy fiber pathway, which are also vulnerable in the pathogenesis of Alzheimer’s ...hippocampal mossy fiber synap- ...at mossy fiber synapses in the absence of Prese- nilin, ...
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NeuroD2 regulates the development of hippocampal mossy fiber synapses
... In vivo shRNA- mediated knockdown of NeuroD2 reduced the density of TE spine heads approximately 40%, similar to the effect observed in NeuroD2 null mice, indicating that NeuroD2 can cel[r] ...
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Roles of Semaphorin 6B and Plexin A2 in Lamina Restricted Projection of Hippocampal Mossy Fibers
... first mossy fibers invade CA3 at around P0, and their number gradually increases during postna- tal development (Amaral and Dent, ...of mossy fibers in early postnatal ...of mossy fibers in P5 and ...
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Plasticity of GABA(B) receptor-mediated heterosynaptic interactions at mossy fibers after status epilepticus
... The concentration of GABA detected by mossy fiber terminals depends not only on the amount of GABA released but also on the efficiency of GABA uptake. The loss of heterosynaptic depres- sion could thus be ...
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Influence of brain-derived neurotrophic factor on pathfinding of dentate granule cell axons, the hippocampal mossy fibers
... aberrant mossy fiber growth induced by K252a that was reported previously ...peptide Mossy fiber pathways in the cultured hippocampal slices were rich in BDNF (Additional file 1), consistent ...
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Rapid and differential regulation of AMPA and kainite receptors at hippocampal mossy fibre synapses by PICK1 and GRIP
... The only previous report investigating the role of PDZ- The finding that KARs and AMPARs can bind to a com- interacting proteins on KAR function was performed in mon pool of PDZ proteins suggests that these proteins cell ...
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Borna Disease Virus Replication in Organotypic Hippocampal Slice Cultures from Rats Results in Selective Damage of Dentate Granule Cells
... the mossy fiber axon projections from 21-day ...and mossy fiber axons running towards the CA3 region of the ...giant mossy fiber terminals in the target area ...showed ...
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Neuroprotective and antiepileptogenic effects of combination of anti-inflammatory drugs in the immature brain
... as mossy fiber sprouting [9]. Mossy fibers are axons of the dentate granule cells which make synaptic contacts with the dendrites of the CA3 pyramidal cells and interneurons in the hilus which ...
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Chronic early life lead (Pb2+) exposure alters presynaptic vesicle pools in hippocampal synapses
... With respect to the RRP/docked vesicles, Pb 2+ expos- ure consistently induced a significant reduction in the number of vesicles that were contacting the PAZ in Mossy Fiber terminals. In primary hippocampal ...
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The Effects of Multiple Gratitude Interventions Among Informal Caregivers of Persons with Dementia and Alzheimer's Disease
... the mossy fiber – CA3 pathway. While controversy surrounds mossy fiber induced LTP (Henze et ...the mossy fiber – CA3 synapse demonstrates the ability to undergo long-term or ...
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Activation of group II metabotropic glutamate receptors blocks zinc release from hippocampal mossy fibers
... every minute (at 16 mHz). These evoked field potentials that were recorded extracellularly at the pyramidal cell layer, using glass microelectrodes (1-10 MΩ) containing a 2 M NaCl solution. The zinc studies were ...
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Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis
... Epilepsy is the third most common neurological disorder, affect- ing nearly 50 million people worldwide. Despite decades of research, satisfactory seizure suppression is still only achieved in just over half of affected ...
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Hippocampal Poly(ADP-Ribose) Polymerase 1 and Caspase 3 Activation in Neonatal Bornavirus Infection
... cell mossy fibers, decreased levels of mossy fiber zinc transporter 3 expression, astrocytic induction of metallothioneins, subcellu- lar redistribution of metallothionein III, and sprouting of ...
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Experimental Research on the Fundamental Mechanical Properties of Basalt Fiber Reinforcement with Epoxy
... Basalt Fiber is an environmentally friendly high performance fiber, it is an ideal low cost fiber to instead of carbon and aramid fiber, Basalt Chopped Strand is chopped from continuous basalt ...
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Electrometric Estimation of Fiber-To-Fiber Contact in a General Fiber Assembly
... The fiber-to-fiber contact has been considered to be fundamental problem of micromechanics, since the mechanical properties of fibrous assemblies are largely related to the number of ...
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COMPARATIVE MECHANICAL TESTING ON HYBRID FIBER REINFORCED POLYMER COMPOSITES
... This paper presents the fabrication of hybrid natural composite using Sisal, Kenaf, Banana, Rice Husk and Carbon fiber reinforced natural composite by compression molding method. The work compares their mechanical ...
10
Fiber to mortar bond behavior in TRM composites: effect of embedded length and fiber configuration
... until fiber rupture occurs ...the fiber tensile strength obtained from direct tensile ...the fiber slipping (that governs the M1-GS1-50 and M1-GS1-75) dissipates more energy than the fiber ...
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