Mouse Hippocampus
Age-dependent changes of p53 and p63 immunoreactivities in the mouse hippocampus
... mammalian target of rapamycin (mTOR) signaling and reactive oxygen species (ROS) generation as follows. Under no or low stress condition, p53 can reduce mTOR signaling and decrease ROS by inducing antioxi- dant genes ...
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Acute neuroinflammation provokes intracellular acidification in mouse hippocampus
... To determine whether neuroinflammation is affecting brain acidity, we measured intra- and extracellular pH levels in mouse hippocampal slices after experimentally induced neuroinflammation. To this end, two ...
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Does the prenatal bisphenol A exposure alter DNA methylation levels in the mouse hippocampus?: An analysis using a high-sensitivity methylome technique
... between mouse strains ...in mouse genome, we were unable to detect statistically sig- nificant changes in CpG methylation levels, which might be due to the stability of the methylated CpG in the C57BL/6 J ...
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Corticotropin releasing factor receptors couple to multiple g proteins to activate diverse intracellular signaling pathways in mouse hippocampus: role in neuronal excitability and associative learning
... and hippocampus-dependent learning in two mouse inbred strains, BALB/c and C57BL/ ...both mouse inbred ...the hippocampus of BALB/c ...
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Age-dependent changes in synaptic plasticity enhance tau oligomerization in the mouse hippocampus
... The aggregation mechanism of phosphorylated tau is an important therapeutic target for tauopathies, including Alzheimer ’ s disease, although the mechanism by which aggregation occurs is still unknown. Because the ...
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Linking Acetyl-Coa Metabolism and Histone Acetylation to Dynamic Gene Regulation in Yeast and Mouse Hippocampus
... hippocampus (Fig. 3.11A). In clear contrast, following memory retrieval, expression of these genes was strongly upregulated in the dorsal hippocampus of eGFP control animals, during the sensitive period ...
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Interactions between inflammatory mediators and corticosteroids regulate transcription of genes within the Kynurenine Pathway in the mouse hippocampus
... and mouse microglia, macrophages, astrocytes [56–60], neu- rons [61], brain endothelial cells [62], and mouse OHSCs ([45]; ...naïve mouse brain ...naïve mouse brain, there is Ido1 enzymatic ...
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The effects of n-6 polyunsaturated fatty acid deprivation on the inflammatory gene response to lipopolysaccharide in the mouse hippocampus
... 5 Genes involved in inflammation in response to n-6 PUFA deprived versus adequate diet using t test data ( p < 0.01) of the microarray. k Nfkb1 , nuclear factor of kappa light polypep[r] ...
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TWIK-1 contributes to the intrinsic excitability of dentate granule cells in mouse hippocampus
... in mouse brain ...using mouse kidney and mouse skeletal muscle tissues (as a positive and a negative control for TWIK-1 expression, respectively: Additional file 1: Figure ...the hippocampus, ...
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<p>Neuropathic Pain Causes Memory Deficits and Dendrite Tree Morphology Changes in Mouse Hippocampus</p>
... We performed a Sholl analysis 38 to evaluate the effect of neuropathic pain on the hippocampal dendrite morphol- ogy. ImageJ software (NIH, USA) was used for all image processing and morphological analyses. For dendrite ...
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Alterations in Brain-Derived Neurotrophic Factor in the Mouse Hippocampus Following Acute but Not Repeated Benzodiazepine Treatment
... Benzodiazepines (BZs) are safe drugs for treating anxiety, sleep, and seizure disorders, but their use also results in unwanted effects including memory impairment, abuse, and dependence. The present study aimed to ...
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Tissue type plasminogen activator is a neuroprotectant in the mouse hippocampus
... the mouse brain lacking tPA activity are more vulnerable to neuronal death following an ischemic ...the hippocampus, as well as ischemic tolerance in wild-type but not tPA- or plasminogen-deficient ...
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Age-related effects of X-ray irradiation on mouse hippocampus
... While knowledge of the effects of low radiation doses is sparse and existing data are mostly based on moderate to high doses (≥ 2 Gy), epidemiological observations raise concern on possible cognitive effects of low doses ...
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Synaptic Pruning by Microglia in Epilepsy
... Recently, inhibitory specific synapse engulfment by microglia has been observed in mice lacking Grn, which codes progranulin [25]. Progranulin is a risk gene for frontotemporal lobar degeneration and decreases the ...
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Original Article Proteomics and bioinformatics analysis of mouse hypothalamic neurogenesis with or without EPHX2 gene deletion
... Pathway enrichment analysis also indicated that TGF-beta signaling pathway, T cell receptor signaling pathway, ErbB signaling pathway and MAPK signaling pathway were engaged in EPHX2 gene deficiency. However, detailed ...
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Apolipoprotein E as a β-amyloid-independent factor in Alzheimer’s disease
... and mouse primary neuron cultures have reduced expression of subunits for all elec- tron transport chain complexes ...apoE3 mouse hippocampus differed in levels of proteins associated with ...
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The 3D OrbiSIMS—label free metabolic imaging with subcellular lateral resolution and high mass resolving power
... Putative annotation of 3'-sulfoGalβ-N-acyl-sphing-4-enine species detected in the negative ion image of the mouse hippocampus in Figure 3D main text... Chemical formula Mass of [M-H]- io[r] ...
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Excitatory/inhibitory balance of serotonergic axon connectivity in the brain
... boutons were involved in synaptic contacts, with a greater proportion of asymmetrical synapses, only on dendritic shafts. We found that 5-HT boutons form almost twice as much triadic contacts with excitatory than ...
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Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer’s disease
... 18-month-old mouse hippocampus, genotype- dependent variations are observed for most peroxisomal and antioxidant ...18-month-old hippocampus clearly show enhanced positivity to PMP70 and Pex14p also ...
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Enriched expression of NF1 in inhibitory neurons in both mouse and human brain
... signaling is responsible for the learning deficits in NF1 [11–14]. Nf1 heterozygous knockout mice showed deficits in spatial learning and working memory, which can be rescued by attenuating RAS activation [12, 14]. ...
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