Mouse model
The Effect of Function-blocking RHAMM Peptides in a Mouse Model of Bleomycin-induced Systemic Sclerosis
... gradient effect proportional to distance away from injection site. Skin biopsies were taken in the same region of injections but standardized exactly over the injection point. Future experiments should include tattooing ...
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Defining New Therapeutics Using a More Immunocompetent Mouse Model of Antibody Enhanced Dengue Virus Infection
... tent mouse model of severe DENV infection with characteristics of the human disease, including vascular leakage, hemoconcen- tration, thrombocytopenia, and liver ...this model, we demonstrate that ...
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Plastin 3 Promotes Motor Neuron Axonal Growth and Extends Survival in a Mouse Model of Spinal Muscular Atrophy
... The marginal effect of PLS3 gene transfer in a SMA mouse model could be explained by various factors: (1) SMND7 mouse model dis- plays severe phenotype with short lifespan. The timing of ...
10
A simple mouse model of pericardial adhesions
... simple mouse model of talc-induced pericardial adhesions, which mimics human pathology and could contribute to solving the clinical issues related to pericardial ...
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Hippocampal epigenetic changes in a mouse model of Fetal Alcohol Spectrum Disorders
... with reduced Pcdh expression dendritic arborisation (Hirayama et al., 2012). The methylation changes may be remnants of earlier dysregulation, perhaps from the synaptogenesis period. This observation may relate to ...
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Characterization of a Listeria monocytogenes meningitis mouse model
... Several mouse and rat listeria models have been developed to study invasive ...single model in which most pathological features seen in human listerial meningitis can be measured, have cre- ated the need ...
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A novel mouse model of lipotoxic cardiomyopathy
... a mouse model of metabolic cardiomyopathy, we generated transgenic mouse lines that overexpress long-chain acyl- CoA synthetase in the heart ...novel mouse model will provide insight ...
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A mouse model of human oral esophageal cancer
... genetic mouse model of oral- esophageal squamous cell cancer that provides new insights into underlying molecular mechanisms and follows the histopathological and genetic changes observed in the human ...
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Revisiting the mouse model of oxygen-induced retinopathy
... the mouse model of oxygen- induced retinopathy (OIR) has become the most widely used, and has played a pivotal role in our understanding of retinal angiogenesis and ocular immunology, as well as in the ...
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Yersinia pestis Subverts the Dermal Neutrophil Response in a Mouse Model of Bubonic Plague
... DCs are phagocytic antigen-presenting cells that serve as im- mune sentinels against tissue damage or invasion by potential pathogens. Immature DCs reside in peripheral tissues like the der- mis. Upon contact with ...
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Mouse model of plasma cell mastitis
... PCM mouse models were established in group C and group ...in mouse models. The first PCM mouse model presented in this study will provide a platform for the investigation of the etiology, ...
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A Mouse Model for Human Norovirus
... Interestingly, our study suggests that Rag ⫺/⫺ ␥ c ⫺/⫺ mice are not susceptible to oral infection. This is in contrast to HuNoV transmission in humans, which occurs via the fecal-oral route, and in gnotobiotic pigs, ...
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A Novel Mouse Model of Enteric Vibrio parahaemolyticus Infection Reveals that the Type III Secretion System 2 Effector VopC Plays a Key Role in Tissue Invasion and Gastroenteritis
... loop model, and thus, in the absence of this phenotype, VopC was not found to impact in vivo virulence ...with mouse versus rabbit intestinal mucosa or differences in the sites of infection (cecum versus ...
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The contribution of specific class I and II histone deacetylases in the development of anxietyrelated behavior in a mouse model of prenatal immune challenge
... As demonstrated by Pujol López et al., it is suggested that anxiety-related behavior observed after prenatal immune challenge, is mediated by epigenetic histone deacetylation. To investigate which HDAC isotypes might be ...
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Streptococcus pneumoniae Transmission Is Blocked by Type Specific Immunity in an Infant Mouse Model
... ABSTRACT Epidemiological studies on Streptococcus pneumoniae show that rates of carriage are highest in early childhood and that the major benefit of the pneumo- coccal conjugate vaccine (PCV) is a reduction in the ...
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A mouse model for the Sézary syndrome
... animal model is a prerequisite for testing newly developed drugs for their efficiency and potential adverse side ...deficient mouse strains are used that accept xenotrans- plants from human tumors or human ...
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Smad3 -signalling and Th2 cytokines in normal mouse airways and in a mouse model of asthma
... Lung histology from naive Smad3-/- mice revealed that the lack of TGF-β −signalling caused a marginal infiltrate of lymphocytes and occasionally modest increases in mucin production in the bronchial epithelium. These ...
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Possible breakdown of dopamine receptor synergism in a mouse model of Huntington's Disease
... The model of basal ganglia function proposed by Albin, Young and Penney (1989) describes two anatomically independent motor pathways, the direct and indirect. However, under normal conditions striatal dopamine ...
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Characterization of a pneumococcal meningitis mouse model
... early in during pneumococcal meningitis [13]. Surpris- ingly, TNF-a was not elevated at any time-point in our model. Previous animal models demonstrated that TNF- a was mainly increased during the first 6 to 24 ...
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Imipramine blocks acute silicosis in a mouse model
... Methods: C57BL/6 alveolar macrophages (AM) exposed to crystalline silica ± IMP in vitro were assessed for IL-1 β release, cytotoxicity, particle uptake, lysosomal stability, and acid sphingomyelinase activity. Short term ...
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