Mouse models with Nod2 gene modifications
Gene × environment interactions in schizophrenia: evidence from genetic mouse models
... the mouse brain are higher during embryonic and early postnatal ages [177] suggesting adverse experiences during these vulnerable periods are more likely to affect the developmental course of dysbindin protein ...
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Optimizing CRISPR/Cas9 for Gene Silencing of SOD1 in Mouse Models of ALS
... transgenic mouse expressing human mutant SOD1 and Cas9 using adeno-associated virus ...on-target gene editing, increased survival, improvements in rotarod, grip strength and weight retention, and a trend ...
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Modulation of the intraocular immune environment by viral gene transfer in mouse models of uveitis
... Whilst known to be a potent inflammatory stimulus, no studies examining the effect of endotoxin upon AAV-mediated gene transfer have been published and no consensus exists on acceptable research grade levels. ...
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Crohn’s Disease: a Role of Gut Microbiota and Nod2 Gene Polymorphisms in Disease Pathogenesis
... and mouse. In vitro, Nod2 stimulation by MDP lead to release of pro-inflammatory NF-κB-dependent cytokines (such as IL-1β, TNF-α and IL-6), as well as se- cretion of IL-23 (which promotes Th17 ...
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Gene therapy and cell reprogramming in mouse models of monogenic hematopoietic stem cell diseases
... that gene therapy based on the infusion of gene corrected-HSCs was confined to the hematopoietic lineage, reinforcing the safety of the FANCA-LV ...integrative gene therapy about secondary effects ...
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Mouse models for breast cancer
... 6 Hormonal signaling and cancer It is well established that the presence of estrogen is a risk factor for mammary tumorigenesis. However, its exact mol- ecular action and the entirety of signaling pathways that are ...
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Mouse Models of Rheumatoid Arthritis
... in mouse RA models and can herald synovitis ...each mouse was ...in mouse rheumatoid arthritis models include measurements of gene expression and protein ...
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Genetic mouse models of migraine
... influence gene regulation rather than directly protein ...a mouse model and defies attempts at determining ...etic mouse models of the ...(KI) mouse lines associated with them, allowing ...
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Graded gene expression changes determine phenotype severity in mouse models of CRX associated retinopathies
... RNA collection and library preparation For each genotype and time point: three biological repli- cates were analyzed, and each replicate consists of four retinas from one male and one female mouse. P21 WT samples ...
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Altered Regulation of Aquaporin Gene Expression in Allergen and IL-13-Induced Mouse Models of Asthma
... Figure 1 IL13 and OVA induced lung remodeling 3.2 OVA sensitization/OVA challenge and mIL-13 instillation result in lung inflammation and reduced lung function The degree of inflammation that occurred in the lungs of ...
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TarGo: network based target gene selection system for human disease related mouse models
... cross-species gene conservation ...novel gene functions and putative driver genes in disease, but are of limited use when predicting sample ...and mouse phenotype ontol- ogies [5, ...provide ...
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GENE KICKED MOUSE: KNOCK OUT MOUSE AND ITS APPLICATION
... knockout mouse is a laboratory mouse in which genes are inactivated, or "knocked out," an existing gene by replacing it or disrupting it with an artificial piece of ...specific gene ...
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Waves of chromatin modifications in mouse dendritic cells in response to LPS stimulation
... histone modifications in mouse DCs during the response to ...histone modifications at promoters and enhancers, relative to the induction of transcription and to TF binding ...of gene bodies ...
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The arylacetamide deacetylase gene in rat and mouse
... In vitro and In vivo regulatory studies o f VLDL secretion The role o f insulin in regulating lipoprotein metabolism is only beginning to be appreciated. Insulin action may be divided into short-term (acute) and ...
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Identification of arthritis related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis
... the gene expression profiles obtained from these RA models well represent those of patients with ...both models may function during the effector ...
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Mouse models of breast cancer metastasis
... of gene expression profiles obtained from mammary gland tumor models initiated by different onco- genes have revealed several common and oncogene-specific targets and similarities with human molecular ...
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Mouse models for the central melanocortin system
... suppressor gene. This finding implicates that Atrn in the A y mouse is required for agouti to effectively antagonize Mc1r and Mc4r in skin and in the brain, ...
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Mouse models for Type 1 Diabetes
... silico models based on these data. To aid the transition from successful mouse therapy to successful human therapy, the biotech company Entelos has created a virtual NOD mouse ...animal models ...
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A new category of autoinflammatory disease associated with NOD2 gene mutations
... the NOD2 gene mutation may constitute a variant of the ...the gene mutation, we pre- sently categorize and designate this disease as a new ...
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A Mouse for Every Gene
... At this point, the other programs are simply making knockout strains, But here, researchers are busy screening the more than 400 mutant mice they have generated over the past year, looking for phenotypes from neuro- ...
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