MRL-lpr
Interferon gamma is required for lupus like disease and lymphoaccumulation in MRL lpr mice
... with MRL- lpr mice are ...of MRL- lpr mice (MRL- lpr/lpr ,, ) showed re- duced IFN- g levels compared with the parental strain, con- comitant with a shift of IgG isotypes ...
9
Transplantation of mesenchymal stem cells ameliorates secondary osteoporosis through interleukin-17-impaired functions of recipient bone marrow mesenchymal stem cells in MRL/lpr mice
... in MRL/ lpr mice, we systemically infused anti-IL-17 anti- body to MRL/ lpr mice at 16 weeks of age for 4 weeks ...infused MRL/ lpr mice ...antibody-treated MRL/ ...
17
Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus
... Female MRL/Lpr mice (Harlan-Olac) were main- tained and assessed for proteinuria (Siemens Multistix analysis) in accordance with Home Office Licences PIL60/12183, PIL60/12950, PPL60/4492 and the ethics review ...
6
Enhanced activation of dendritic cells by autologous apoptotic microvesicles in MRL/lpr mice
... and MRL/lpr ...of MRL/lpr or BALB/c mice were reconstituted in 25 μl medium, adjusted to acquire equal amounts in protein equivalents, and 2 or 10 μl was added to DC in a 96- well plate ...
14
ALW peptide ameliorates lupus nephritis in MRL/lpr mice
... Fibrosis is one of the main pathological mechanisms in progressive LN and plays an important role in the devel- opment of end-stage renal disease which is mainly mani- fested in increased synthesis of extracellular ...
14
Neuropsychiatric systemic lupus erythematosus persists despite attenuation of systemic disease in MRL/lpr mice
... nipulated MRL/lpr mice (data not ...in MRL/+ → MRL/ lpr, MRL/lpr → MRL/lpr, and unmanipulated MRL/lpr mice, many of which were ...As ...
13
Treatment with Anti-HMGB1 Monoclonal Antibody Does Not Affect Lupus Nephritis in MRL/lpr Mice
... in MRL/lpr mice. Seven-week-old MRL/lpr mice were injected intraperitoneally twice weekly for 10 wks with 50 μg monoclonal anti-HMGB1 (2G7, mouse IgG2b) (n = 12) or control antibody (n = ...
10
Establishment of Monoclonal Anti-Retroviral gp70 Autoantibodies from MRL/lpr Lupus Mice and Induction of Glomerular gp70 Deposition and Pathology by Transfer into Non-Autoimmune Mice
... concentrations of hybridoma-derived IgG were determined for a limited number of hybridoma clones in transplanted SCID mice. Average concentrations of serum IgG were in the same range among the mice transplanted with a ...
11
Original Article Therapeutic effect of dihydroartemisinin on lupus-prone MRL/lpr mice and its mechanism of action
... lupus-prone MRL/lpr mice are com- monly used models of SLE because their responses to SLE are similar to those of ...female MRL/lpr mice were used to inves- tigate the immunoregulatory effect ...
6
Histone deacetylase inhibitors modulate renal disease in the MRL lpr/lpr mouse
... by MRL-lpr/lpr splenocytes, it is likely that the chromatin architecture at the IFN-γ pro- moter is different ...by MRL-lpr/lpr splenocytes and upregulation of IFN- γ in human ...
15
The new complement inhibitor CRIg/FH ameliorates lupus nephritis in lupus-prone MRL/lpr mice
... in MRL/lpr mice treated with normal saline, while skin lesion was not observed in CRIg/FH treated MRL/lpr ...in MRL/lpr mice treated with ...in MRL/lpr mice was ...
8
Suppression of lupus nephritis and skin lesions in MRL/lpr mice by administration of the topoisomerase I inhibitor irinotecan
... to MRL/lpr mice, the results were more difficult to ...the MRL/lpr mice- utilizing studies have finished ...in MRL/lpr ...
11
Peroxynitrite Formation and Decreased Catalase Activity in Autoimmune MRL-lpr/lpr Mice
... of MRL-lpr/lpr mice with the NOS inhibitor NMMA reduces the extent of ...in MRL-lpr/lpr mice treated with ...of MRL-lpr/lpr mice may result in enhanced ...
14
Methylprednisolone attenuates lipopolysaccharide-induced Fractalkine expression in kidney of Lupus-prone MRL/lpr mice through the NF-kappaB pathway
... in MRL/lpr mice At the age of 20 weeks, the renal cortex of MRL/lpr mice showed widening of the mesangial region, in- creased mesangial matrix, proliferation of mesangial cells (the degree of ...
8
Analysis of C4 and the C4 binding protein in the MRL/lpr mouse
... C4bp-deficient MRL mice. Given that the MRL mouse has long been held as a murine model of the immune complex renal injury seen in patients with lupus nephritis, it was surprising that mice lacking the ...
10
Highly selective inhibition of Bruton’s tyrosine kinase attenuates skin and brain disease in murine lupus
... Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects different end organs, including skin and brain. We and others have previously shown the importance of macrophages in the ...
11
IgG3 deficiency extends lifespan and attenuates progression of glomerulonephritis in MRL/lprmice
... in MRL/lpr mice ...the MRL/lpr or other inbred strains prone to autoim- mune disease ...the MRL background has been correlated with more severe renal disease ...the MRL/ ...
17
Phosphorylation of IRF4 by ROCK2 regulates IL 17 and IL 21 production and the development of autoimmunity in mice
... unpublished observations), another mouse model in which spon- taneous autoimmunity is highly dependent on the presence of IL-21 (61–63). The mechanisms underlying the aberrant activa- tion of ROCK2 in these additional ...
17
The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis
... Plasma creatinine was measured using the colorimetric microplate assay. The creatinine clearance was calculated from the plasma creatinine concentra- tion and a timed urine sample. Kidney weights were determined and the ...
23
Importance of spliceosomal RNP1 motif for intermolecular T B cell spreading and tolerance restoration in lupus
... P140-treated MRL/lpr mice (18-week-old at the time of the experiment) were challenged intranasally (in) with A/NT/60/68 influenza virus (H3N2 strain) in allantoic fluid using a dose pre- determined to ...
10