MRL/lpr mice
Original Article Therapeutic effect of dihydroartemisinin on lupus-prone MRL/lpr mice and its mechanism of action
... By comparing the changes in urine protein, renal histopathology, and physical conditions among the four groups, the therapeutic effect of DHA on lupus-prone MRL/lpr mice was eval- uated. From 3 days ...
6
ALW peptide ameliorates lupus nephritis in MRL/lpr mice
... Different antibodies had differential pathogenic poten- tial, which is related to the affinity and specificity to renal antigens, homology of the idiotype, and the nature and location of specific amino acid residues in ...
14
Treatment with Anti-HMGB1 Monoclonal Antibody Does Not Affect Lupus Nephritis in MRL/lpr Mice
... of MRL/lpr mice does not affect albuminuria and HMGB1 urine ...of MRL/MPJ (n = 10) and MRL/lpr (n = 10–12) mice at wks 7, 11 and ...of MRL/MPJ (n = 10) and ...
10
Transplantation of mesenchymal stem cells ameliorates secondary osteoporosis through interleukin-17-impaired functions of recipient bone marrow mesenchymal stem cells in MRL/lpr mice
... is generally caused by disruption of bone remodeling, which is related to menopause and aging, whereas secondary osteoporosis in SLE is multifactorial and in- volves excessive systemic inflammation and long-term ...
17
Reno protective effect and mechanism study of Huang Lian Jie Du Decoction on lupus nephritis MRL/lpr mice
... female MRL/lpr mice ...China). Mice were fed under specific pathogen-free conditions at 24 ± 1 °C and 50 ± 5 % relative humidity with a 12 h light/dark cycle and with free access to standard ...
11
Interferon gamma is required for lupus like disease and lymphoaccumulation in MRL lpr mice
... lupus mice treated with IFN- g (7) showed accel- erated disease manifestations while, conversely, treatment with anti-IFN- g antibody (7, 8) or soluble IFN- g R (8) early in life caused significant delay in ...
9
Enhanced activation of dendritic cells by autologous apoptotic microvesicles in MRL/lpr mice
... and MRL/lpr ...of MRL/lpr or BALB/c mice were reconstituted in 25 μl medium, adjusted to acquire equal amounts in protein equivalents, and 2 or 10 μl was added to DC in a 96- well plate ...
14
Neuropsychiatric systemic lupus erythematosus persists despite attenuation of systemic disease in MRL/lpr mice
... MRL/lpr mice were previously reported to display in- creased hippocampal F4/80+ microglia staining ...nipulated MRL/lpr mice (data not ...in MRL/+ → MRL/ ...
13
Suppression of lupus nephritis and skin lesions in MRL/lpr mice by administration of the topoisomerase I inhibitor irinotecan
... Saline-treated MRL/lpr mice started to develop severe proteinuria from 12 weeks of ...that MRL/lpr mice treated with low-dose irinotecan developed more severe lupus-like skin ...
11
Methylprednisolone attenuates lipopolysaccharide-induced Fractalkine expression in kidney of Lupus-prone MRL/lpr mice through the NF-kappaB pathway
... (MRL/lpr) mice develop spontan- eous autoimmune diseases and the main histopatho- logical features of the glomerular lesions resemble those shown in human lupus ...in MRL/lpr ...
8
The new complement inhibitor CRIg/FH ameliorates lupus nephritis in lupus-prone MRL/lpr mice
... female MRL/lpr mice (weighing ...the MRL/ lpr mice were randomly assigned into treatment groups (N = 8 in each group) to receive twice weekly intraperito- neal injection of ...
8
Stochastic control of anti Sm autoantibodies in MRL/Mp lpr/lpr mice
... autoimmune mice consistently show an approximately 25% incidence of the systemic lupus erythematosus marker autoantibody ...5-mo-old MRL/lpr mice was not an artifact of an insensitive assay, ...
8
Peroxynitrite Formation and Decreased Catalase Activity in Autoimmune MRL-lpr/lpr Mice
... diseased mice also produce elevated levels of superoxide and hydrogen peroxide ...these mice, although several nitration pathways could exist simultaneously ...of MRL-lpr/lpr ...
14
IgG3 deficiency extends lifespan and attenuates progression of glomerulonephritis in MRL/lprmice
... in MRL/lpr mice ...in mice of the MRL/lpr or other inbred strains prone to autoim- mune disease ...the MRL background has been correlated with more severe renal disease ...
17
Enhanced expression of interferon inducible protein 10 associated with Th1 profiles of chemokine receptor in autoimmune pulmonary inflammation of MRL/lprmice
... in MRL/lpr mice, the specific profiles of IP-10, of ligand for chemokine receptor, and of CXCR3 of Th1 phenotype in various aspects of murine lupus remain incompletely ...
9
Highly selective inhibition of Bruton’s tyrosine kinase attenuates skin and brain disease in murine lupus
... the MRL-lpr/lpr murine model of SLE, and examined the effect of treatment on skin and brain ...in MRL/lpr mice. Specifically, BI-BTK-1 treated mice had fewer macroscopic ...
11
Bortezomib treatment induces a higher mortality rate in lupus model mice with a higher disease activity
... For the study, 96-well ELISA plates (Costar, Corning, NY, USA) were coated overnight with goat anti-mouse Ig anti- body (SouthernBiotech, Birmingham, AL, USA) or with calf thymus DNA (20 μg/ml) treated with S1 nuclease ...
14
Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus
... the MRL/Lpr and Lyn –/– mouse models of lupus, 8,9 as MyD88 signal- ling is essential for ANA production, activation of nephrotoxic T cells and ...in MRL/Lpr mice and its ...
6
B cell and/or autoantibody deficiency do not prevent neuropsychiatric disease in murine systemic lupus erythematosus
... depleted MRL/lpr mice continued to exhibit features of the characteristic NPSLE phenotype of this ...hCD20-DTA/MRL/lpr mice demon- strated depression-like behavior and cognitive ...
14
Establishment of Monoclonal Anti-Retroviral gp70 Autoantibodies from MRL/lpr Lupus Mice and Induction of Glomerular gp70 Deposition and Pathology by Transfer into Non-Autoimmune Mice
... our mice were killed and examined within 5 weeks after a single pristane injection, and thus it is unlikely that the injec- tion of pristane alone was responsible for the development of glomerular lesions in the ...
11