Mst1/2
The Hippo pathway in disease and therapy: cancer and beyond
... of MST1/2 and/or LATS1/2 kinases functioning upstream of YAP/ ...Since MST1/2 and LATS1/2 kinases are regulated by multiple PPIs, which directly or indirectly affect their kinase ...
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Original Article MST1 inhibits cell proliferation and invasion of non-small-cell lung cancer by regulating YAP phosphorylation and Hippo pathway
... [1, 2]. It was reported that MST1 is involved in diverse functions including apoptosis, autophagy, and cellular proliferation in different organs or tis- sues ...[3-11]. MST1 deficient or mutant mice ...
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Hippo signaling components, Mst1 and Mst2, act as a switch between self renewal and differentiation in Xenopus hematopoietic and endothelial progenitors
... control. Mst1 and Mst2 were identified as homologs of hippo and as core kinases of the Hippo pathway in ...of Mst1 and Mst2 during Xenopus primitive hematopoiesis. We showed that Mst1 and Mst2 were ...
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Hippo signaling interactions with Wnt/β catenin and Notch signaling repress liver tumorigenesis
... the MST1/2, β-catenin TKO mouse line, we found a larger number of less-dif- ferentiated HCCs and ICCs, but substantially fewer hepatocellu- lar ademomas (HCAs) compared with our findings in the ...
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Mst1 and Mst2 kinases: regulations and diseases
... [61]. Mst1 (but not Mst2) and YAP proteins are detected in the wild type pan- creas during the secondary transition stage, and was al- most undetectable at birth before returning to higher levels at postnatal day ...
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Integrin α2β1 inhibits MST1 kinase phosphorylation and activates Yes-associated protein oncogenic signaling in hepatocellular carcinoma
... Unlike that binding to extracellular matrix, cell-cell interaction activates MST1/2 thereby phosphorylating LATS1/2 using SAV1 as a cofactor. Activated LATS1/2 (in complex with Mob1) ...
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Vol 68, No 3 (2016)
... proteins MST1/2 in osteoclast ...as MST1 showed a more prominent change than MST2 in our system, we evaluated the Hippo pathway with osteo- clast differentiation through ...
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<p>YAP1 Promotes Tumor Invasion and Metastasis in Nasopharyngeal Carcinoma with Hepatitis B Virus Infection</p>
... 23,24 MST1/2 interact with and phosphorylate LATS1/2 ...uence MST1/2 and LATS1/2, which lead us to wonder how YAP1 function in homeostasis ...
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Overexpression of Mst1 reduces gastric cancer cell viability by repressing the AMPK-Sirt3 pathway and activating mitochondrial fission
... Cell death was determined via the lactate dehydrogenase (LDH) release assay, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining, and caspase protein activity assay. The TUNEL experiment was ...
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Cell surface marker profiling of human tracheal basal cells reveals distinct subpopulations, identifies MST1/MSP as a mitogenic signal, and identifies new biomarkers for lung squamous cell carcinomas
... The origin of the observed surface marker heterogen- eity is not clear. Some markers showed substantial varia- tions in expression between different basal cell isolates, which could simply reflect highly variable ...
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Activation of Pro survival CaMK4β/CREB and Pro death MST1 signaling at early and late times during a mouse model of prion disease
... To analyze GFAP and total PrP, brain homogenates were mixed with a one-fourth volume of 5X SDS loading buffer. Then, 100 μg of denatured protein was loaded per linear cm onto 15-well 12% SDS-PAGE gels (Mini-PROTEAN; ...
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MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway.
... of MST1 as reported in PhosphositePlus (31/01/2014, ref ...entire MST1 linker region (aa 327– 487) were also synthesized in both phospho- and nonphosphorylated versions (for every serine, threonine, or ...
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Mst1 overexpression combined with Yap knockdown augments thyroid carcinoma apoptosis via promoting MIEF1-related mitochondrial fission and activating the JNK pathway
... to Mst1, overexpression of Mst1 via tanshinone IIA increases the therapeutic sensitivity of colorectal cancer to IL-2-me- diated cytokine ...cancer, Mst1 upregulation impairs mitochondrial ...
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Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury
... I/R. Mst1 is activated and phos- phorylates Bcl-xL in the heart in response to I/R (4, 16, ...by Mst1 activation, as evidenced by an increase in Mst1 phosphorylation at Thr183, and this was followed ...
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MST1, a key player, in enhancing fast skeletal muscle atrophy
... of MST1 deficient mice was described previously ...and MST1 KO (n = 7) mice, both male and female, were ...to 2 mm above the ground of the cage for 7 and 14 ...
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Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice
... Endogenous Rassf1A represses cardiac fibroblast proliferation. (A–G) Fibroblasts were isolated from neonatal rat hearts and passaged a minimum of 3 times prior to experimentation. (A) Representative immunoblot ...
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MST1 dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane
... far, 2 effector molecules, namely synaptotagmin-like protein 1 (JFC1, encoded by Sytl1 in mice) and Munc13-4 (UNC13D), have been identified as interact- ing with Rab27a in neutrophils ...
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Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy
... (Table 2). Necrop- sy of Tg-Mst1 at 3 months old indicated dilation of all four cardiac chambers, mural thrombus formation in both atriums, and reduced wall thickness, consistent with the findings of ...
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Computational Studies of Multi-Active Site Enzymes
... chapter 2, the reaction mechanism of pre-transfer editing of MST1 was investigated using microsecond molecular dynamics (MD) simulations and umbrella sampling, employing quantum mechanics/molecular ...
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In-Silico Molecular Characterization of MST1 Protein
... Type 2 DM begins with insulin resistance, a condition in which cells fail to respond to insulin ...properly. MST1 a protein kinase of the STE20 ...of Mst1, which is close to the caspase-3 recognition ...
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