MT1/2
High threshold of β1 integrin inhibition required to block collagen I-induced membrane type-1 matrix metalloproteinase (MT1-MMP) activation of matrix metalloproteinase 2 (MMP-2)
... regulate MT1- MMP expression. The interaction between β1 integrin and MT1-MMP blocks MT1-MMP internalization and causes increased MMP-2 ...that MT1-MMP is regulated by and/or associated ...
13
Direct anti-metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP-2, MMP-9 and MT1-MMP in tumours
... The DNA enzyme Dz13, targeted against the oncogene c-Jun, is capable of inhibiting various model tumours in mice albeit in ectopic models of neoplasia. In previous studies using orthotopic models of disease, the ...
8
Modulation of RECK levels in Xenopus A6 cells: effects on MT1-MMP, MMP-2 and pERK levels
... between MT1-MMP levels and ERK activation into pERK, as well as pro-MMP-2 activation into ...of MT1-MMP demonstrated low ERK acti- vation and high pro-MMP-2 ...of MT1-MMP demonstrated ...
10
A MT1-MMP/NF-κB signaling axis as a checkpoint controller of COX-2 expression in CD133(+) U87 glioblastoma cells
... human MT1-MMP gene [48] and NF-κB-mediated induction of MT1-MMP was con- firmed in murine melanoma cells [49] and in human fib- rosarcoma cells ...a MT1-MMP-mediated signaling cascade that leads to ...
10
Inhibition Of MT1-MMP Proteolytic Function And ERK1/2 Signalling Influences Breast Cancer Cell Migration And Invasion Through Changes In MMP-2 And MMP-9 Expression
... active MT1-MMP, the 63 kDa active form of MMP-2 cleaves a wide variety of substrates found within the extracellular milieu (Khasigov et ...MMP- 2 has been linked with poor prognosis in multiple ...
109
Regulation of MT1-MMP/MMP-2/TIMP-2 axis in human placenta
... of MT1-MMP in placental tissue; however, remodeling of chromatin by a pharmacologic agent such as AZA potentiates an infection-related increase in ...MT1-MMP. MT1-MMP is a powerful activator of MMP2 ...
8
ELK3 Suppresses Angiogenesis by Inhibiting the Transcriptional Activity of ETS-1 on MT1-MMP
... the MT1-MMP promoter (WT) was generated by PCR amplification from hu- man genomic DNA based on the GenBank™ acces- sion number AB011056 (from 570 to 2114 bp, marked as -1518 to +27 bp in ...The MT1-MMP ...
10
Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180.
... lacking the collagen-binding domain (East et al., 2003) or empty vector (Fig. 4F). Importantly, expression in Endo180-siRNA- treated cells of wild-type murine Endo180, but not the non- collagen-binding Endo180 mutant, ...
7
The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane type matrix metalloproteinase 1 and cyclooxygenase 2 expression
... both MT1-MMP expression and cell invasion by HBx is dependent on cyclooxygenase-2 (COX-2) ...of MT1-MMP and COX-2 and provide new insights into the mechanism of action of this viral ...
9
Coordinated elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution
... tion. MT1-MMP, for example, has various functions that include the degradation of several types of collagen, the activations of other MMPs and activities related to apop- ...of MT1- MMP and MMP-2 ...
7
The role of Xenopus laevis RECK in ECM remodeling and tissue patterning
... as MT1-MMP, a multi-functional cell surface MMP (Takagi et ...from MT1-MMP, and all TIMPs are viable (Amar et al., 2017). This positions MT1-MMP as a uniquely important molecule, and therefore its ...
200
MT1-MMP in breast cancer: induction of VEGF-C correlates with metastasis and poor prognosis
... of MT1-MMP, VEGF-C and glyceraldehyde-3-phos- phate dehydrogenase (GAPDH) as an internal control in each reaction was carried out by polymerase chain reaction (PCR) with the following primers: MT1-MMP, ...
9
Effects of matrix metalloproteinases on the fate of mesenchymal stem cells
... with MT1-MMP. The MT1-MMP senses the surrounding microenvironment through the binding of β 1 integrin and the ...overexpressing MT1-MMP during osteogenic differentiation was found to upregulate ...
12
MT3 melatonin binding site, MT1 and MT2 melatonin receptors are present in oocyte, but only MT1 is present in bovine blastocyst produced in vitro
... Institutional approval was received for the work with embryos in this study (94/2010-ICB). The IVP was per- formed as previously described [33]. Briefly, bovine ovaries were obtained from a slaughterhouse and transported ...
7
Covariance Matrices for Differential and Angle-Integrated Neutron-Induced Elastic and Inelastic Scattering Cross Sections of 56Fe
... Figure 2 shows the correlation matrices between angle- integrated cross sections, including the total cross section (MT1), elastic scattering cross section (MT2), total inelastic scattering cross sections ...
7
Aquaporin-3 positively regulates matrix metalloproteinases via PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells
... date, MT1-MMP, MMP-2 and MMP-9 are the major enzymes involved in degrading types I and IV collagen and the extracellular matrix(ECM) ...mortality. MT1-MMP, MMP-2 and MMP-9, which are ...
6
Initiatives and New Trends Towards Stem Education in Turkey
... In the study, the articles included in the thematic content analysis were classified as engineering and design "MT1", chemistry and mathematics education articles "KM1" in the form of science ...
10
HIV-1 transgene expression in rats induces differential expression of tumor necrosis factor alpha and zinc transporters in the liver and the lung
... Figure 2 (panels A&B), liver and lung tissues were probed by real-time PCR for the expression of the zinc storage protein, MT1 and the zinc exporter, ...in MT1 and ZNT1 in the livers of HIV-1 ...
11
Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo
... cell-surface MT1- MMP activity, screening for 2nd generation higher affinity antibody fragments was carried out such that the binding epitope and inhibition mechanism was ...TIMP- 2 for MT1-MMP ...
20
Expression of CD133 and Extracellular Matrix Molecules in Malignant Brain Tumors
... metastasis, 2 gliomas) were studied to investigate the expression-patterns of CD133, EGFR, MT1-MMP, and MMP7 using the immunostaining and RT-PCR ...respectively. MT1-MMP immunostaining was also ...
5