MT1-MMP
High threshold of β1 integrin inhibition required to block collagen I-induced membrane type-1 matrix metalloproteinase (MT1-MMP) activation of matrix metalloproteinase 2 (MMP-2)
... regulate MT1- MMP expression. The interaction between β1 integrin and MT1-MMP blocks MT1-MMP internalization and causes increased MMP-2 ...that MT1-MMP is ...
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A MT1-MMP/NF-κB signaling axis as a checkpoint controller of COX-2 expression in CD133(+) U87 glioblastoma cells
... the MT1-MMP/COX-2 signalling axis, we used magnetic cell sorting (MACS) technology to isolate CD133(+) cells from the parental U87 glioma cell ...Moreover, MT1-MMP and COX-2 gene expression ...
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Modulation of RECK levels in Xenopus A6 cells: effects on MT1-MMP, MMP-2 and pERK levels
... (MMP-2, MMP-9, MT1-MMP, and TIMP-2) were normalized to the internal standard of ...(5΄–3΄): MT1-MMP F: CAT GGG CAG CGA TGA AGT CT, R: CCA GTA TTT GTT CCC CTT GTA GAA GTA; ...
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Direct anti-metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP-2, MMP-9 and MT1-MMP in tumours
... stromal MMP-9 and MT1-MMP is independently associated with negative prognosis ...express MMP-9 [23]. In uroepithelial carcinoma patients, increased pro-MMP-9 and active MMP-2 ...
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Original Article Detection of RECK and MT1-MMP expression in bladder urothelial carcinoma using quantum-dot immunofluorescence and its clinical significance
... 3 MMP family members, including MMP- 2, MMP-9, and ...of MT1-MMP. The inhibition of MMP-9 by RECK is at post-translation ...of MMP-9 and its activity by inhibiting its ...
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Effect of Matrine on HPAC cell migration by down-regulating the expression of MT1-MMP via Wnt signaling
... HPAC cells were lysed in RIPA buffer [50 mM Tris (pH 7.4), 150 mM NaCl, 1 % Triton X-100, 0.1 % SDS, 1 % sodium deoxycholate, 5 mM EDTA, 100 mM NaF, and 1 mM Na3VO4] containing a protease inhibitor cocktail for 30 min on ...
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Regulation of MT1-MMP/MMP-2/TIMP-2 axis in human placenta
... detect MT1-MMP mRna expression in tissues treated with/without 5 µg/ml lPs with/without prior 5 µM aZa ...treatment. MT1-MMP mRna was significantly increased in explants pre-treated with aZa ...
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ELK3 Suppresses Angiogenesis by Inhibiting the Transcriptional Activity of ETS-1 on MT1-MMP
... the MT1-MMP promoter induced by ETS-1 factor was attenuated ELK3 ...the MT1-MMP promoter. MT1-MMP knockdown in the ELK3 knockdowned cells resulted in the decrease of tube ...
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MT1-MMP in breast cancer: induction of VEGF-C correlates with metastasis and poor prognosis
... as MT1-MMP. We hypothesised that MT1-MMP also plays an important role in lymphangiogenesis through an interaction with ...and MT1-MMP expression and compared these results with ...
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Original Article E6/E7 oncoproteins of high risk HPV-16 upregulate MT1-MMP, MMP-2 and MMP-9 and promote the migration of cervical cancer cells
... promoted MT1-MMP, MMP-2 and MMP-9 in cervical can- cer ...cells. MT1-MMP, MMP-2 and MMP-9 were upregulated in the HPV16 E6/E7-positive cervi- cal cancer cell lines, ...
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Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo
... metalloproteinase-14, MT1-MMP, has been implicated in pericellular proteolysis with an important role in cellular invasion of collagenous ...to MT1-MMP that potently and specifically inhibit ...
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MT1-MMP dependent repression of the tumor suppressor SPRY4 contributes to MT1-MMP driven melanoma cell motility
... of MT1- MMP. SPRY1 and 2 were also identified as possible MT1- MMP targets, however, neither SPRY1 nor 2 showed any significant correlation with melanoma progression and importantly, did not ...
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MT1 MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization
... with their WT littermates (data not shown). Moreover, we have detected increased frequencies of circulating HPCs in CD44- deficient mice, indicative of defective interactions with the BM microenvironment in the absence ...
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Combined features based on MT1 MMP expression, CD11b + immunocytes density and LNR predict clinical outcomes of gastric cancer
... The MT1-MMP expression and CD11b + immunocytes dens- ity were digitally evaluated by Image-Pro Plus ...of MT1-MMP in each photograph was measured, and its ratio to total area of each ...
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Inhibition Of MT1-MMP Proteolytic Function And ERK1/2 Signalling Influences Breast Cancer Cell Migration And Invasion Through Changes In MMP-2 And MMP-9 Expression
... active MT1-MMP, the 63 kDa active form of MMP-2 cleaves a wide variety of substrates found within the extracellular milieu (Khasigov et ...2003). MMP-2 has substrate specificity for ECM and ...
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MT1-MMP Mediates the Migratory and Tumourigenic Potential of Breast Cancer Cells via Non-Proteolytic Mechanisms
... of MT1-MMP expression achieved using transient transfection was a factor behind the discrepancies between my observation and other reports, I created clonal MCF-7 cell lines that stably express ...
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Inhibitory Effect of Ethyl Pyruvate on Orthotopic Transplantation of Gastric Cancer in Severe Combined Immunodeficiency Mice
... The mice were sacrificed 30 days after treatment, and gastric cancer tissues and metastatic liver tumor tissues were taken and embedded into wax blocks, and conventional 5 µm sections were prepared. The protein ...
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Expression of the metalloproteases MMP 1, MMP 2, MMP 3, MMP 9, MMP 11, TIMP 1 and TIMP 2 in angiocentric midfacial lymphomas
... of MMP-9 and MMP-2 ...of MMP-2, for a ternary complex with proMMP- 2 and MT1-MMP ...lines, MMP-9 is induced by the EBV latent membrane protein-1 (LMP-1), particu- larly in ...
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Ras Modifies Proliferation and Invasiveness of Cells Expressing Human Papillomavirus Oncoproteins
... and MT1-MMP expression was ...of MT1-MMP and invasiveness, the in- vasion induced by the MEK1-SDSE was attenuated compared with that induced by H-rasV12 and 18E7 coexpression, sug- gesting ...
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Mechanosensitive caveolin-1 activation-induced PI3K/Akt/mTOR signaling pathway promotes breast cancer motility, invadopodia formation and metastasis in vivo
... significantly enhanced tumor dissemination to the lungs, and more metastatic foci were observed. The survival of Cav-1 Y14D group was significantly lower as compared with that of the other groups. Histological ...
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