mtDNA and Nuclear Genes
Nuclear–Mitochondrial Epistasis and Drosophila Aging: Introgression of Drosophila simulans mtDNA Modifies Longevity in D. melanogaster Nuclear Backgrounds
... and nuclear genes, the mitochondrial genetics of aging should be controlled by variation in (1) mtDNA, (2) nuclear genes, or (3) nuclear–mtDNA ...carrying mtDNA ...
13
Reduced nuclear DNA methylation and mitochondrial transcript changes in adenomas do not associate with mtDNA methylation
... for nuclear encoded genes while HT-seq was used to count reads for the mitochondria genes (Heinz et ...using genes in both the nuclear genome and mtDNA (Human GRCh37/hg19 ...for ...
8
Next generation sequence analysis for mitochondrial disorders
... entire mtDNA genome and coding sequen- ces within >3,500 exons of 362 nuclear genes for proteins involved in mitochondrial function, for an aggregate target size of approximately ...of ...
10
Suppression of a Nuclear aep2 Mutation in Saccharomyces cerevisiae by a Base Substitution in the 5′-Untranslated Region of the Mitochondrial oli1 Gene Encoding Subunit 9 of ATP Synthase
... T HE formation of mitochondrial enzyme complexes limited subsets. The steps in gene expression and pro- responsible for oxidative phosphorylation requires tein maturation in which the products of these special- the ...
12
The origin and early evolution of mitochondria
... protein-coding genes in R. americana mtDNA to only three in the mitochondrial genome of apicomplexans [8,9], a group of strictly parasitic protists (specific relatives of dinoflagellates) including such ...
5
Computational Biology Methods and Their Application to the Comparative Genomics of Endocellular Symbiotic Bacteria of Insects
... include nuclear transgenesis of genes involved in OXPHOS and mtDNA maintenance, allotopic expression of mitochon- drial genes, chemically induced models, and transmito- chondrial approaches ...
10
Association of nuclear and mitochondrial genes with audiological examinations in Iranian patients with nonaminoglycoside antibiotics-induced hearing loss
... and nuclear genes may increase the penetrance of deafness and that there may be an association between nuclear gene variation and mito- chondrial deafness with cochlear implant in Iranian ...of ...
12
The genomic impact of historical hybridization with massive mitochondrial DNA introgression
... Regarding nuclear genes reported to be involved in the mitochondria (“mitonuc” genes), we found no significant differences of pairwise species dN/dS compared to back- ground genes (Wilcoxon ...
20
Mitochondrial-Nuclear Interactions Mediate Sex-Specific Transcriptional Profiles in Drosophila
... of mtDNA substitution in one nuclear background was different from the effect in the ...many genes in both males and females, however, we found females were generally more sensitive to mtDNA ...
42
The role of mitochondrial DNA in the tumor biology of glioblastoma multiforme and multiple myeloma
... of nuclear-encoded mitochondrial factors, which must be imported into the ...These nuclear genes are either translated by ribosomes in the cytosol 3 , or co-translated during the import process into ...
372
Nuclear dynamics: where genes are and how they got there
... have revealed that these can be remarkably dynamic struc- tures. CBs traverse the nucleus and undergo both joining and splitting reactions [49]. CBs could also be detected moving to and from the periphery of nucleoli and ...
7
Nuclear genes involved in maintenance of the malarial plastid
... organellar genes are transferred to the nucleus, where the gene sequences must acquire the appropriate motifs necessary for their expression in the nuclear environment, and an in-frame upstream sequence ...
217
Mutation Analysis of the Mitochondrial tRNA Genes in Iranian Coronary Atherosclerosis Patients
... mic. This mutation was never reported as a neutral polymorphism and was not detected in normal in- dividuals from different ethnic backgrounds. The m.5725T>G change considers as pathogenic mutation for the subsequent ...
7
Species delimitation based on mtDNA genes suggests the occurrence of new species of Mesocestoides in the Mediterranean region
... In the present study, several individuals of Mesoces- toides spp. from different hosts in southern Italy and Tunisia have been studied by sequencing of the cyto- chrome c oxidase subunit 1 (cox1) and NADH dehydro- genase ...
11
Cryptic Diversity within the Major Trypanosomiasis Vector Glossina fuscipes Revealed by Molecular Markers
... v. G. f. fuscipes populations from Ethiopia (supported by mtDNA, YcfW, period and microsatellites). We propose that this group is provisionally identified as G. fuscipes type B. The status of the central DRC ...
12
Complete Replacement of the Mitochondrial Genotype in a Bos indicus Calf Reconstructed by Nuclear Transfer to a Bos taurus Oocyte
... particular nuclear genotype by continuous mating of founder females and their female offspring to males of the desired nuclear ...original nuclear genotype. Animal cloning by nuclear transfer ...
6
The mitochondrial ATPase6 gene is more susceptible to mutation than the ATPase8 gene in breast cancer patients
... The functional role of ATPase6/8 variants in tumori- genesis is debatable; however, some of these variants are located in structurally and functionally important regions of the proteins. For instance, the A8860G ...
9
Low Nucleotide Diversity in Chimpanzees and Bonobos
... Comparison of the levels of nucleotide diversity in humans and apes may provide much insight into the mechanisms of maintenance of DNA polymorphism and the demographic history of these organisms. In the past, abundant ...
8
Interspecific hybridization in seahorses: artificially produced hybrid offspring of Hippocampus kuda and Hippocampus reidi
... Discordance between morphological results (melanophore and development patterns) and the molecular result of mtDNA cytochrome b (neighbor-joining tree) paradoxically confirmed interspecific hybridization of two ...
8
Evolution and inheritance of animal mitochondrial DNA: rules and exceptions
... fungi mtDNA has been reported in the early 80s of past century [61, 62], but animal mtDNA was considered for decades as a non- recombining genome ...animal mtDNA was based on the assumption of ...
7