MTHFR gene
MTHFR gene polymorphism and associated nutritional deficiency in the etiology and pathogenesis of Down syndrome
... them. MTHFR is one of the major enzymes of the folate metabolic path- way, whose genetic polymorphisms have been associated with chromosome damage and maternal risk of birth of a child with DS ...the MTHFR ...
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Association of mthfr gene polymorphisms c677t and a1298c with coronary artery disease
... for MTHFR A1298C polymorphism, meta- analyses observations for MTHFR C677T SNP reflected the inconsistency in the findings reported by several individual ...with MTHFR CC genotype (Lewis et ...in ...
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Methotrexate effect on biochemical indices of psoriasis patients depends on MTHFR gene polymorphism
... between MthFR gene polymorphisms (OMIM 607093) responses to MTX treatment and adverse reactions to MTX was discove red in patients with rheumatoid arthritis ...and MthFR genes and either MTX efficacy ...
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Mutations in the MTHFR gene are not associated with Methotrexate intolerance in patients with juvenile idiopathic arthritis
... the MTHFR gene also lead to higher plasma homo- cysteine levels, and homocysteine plasma levels have been shown to increase according to the number of mu- tations in an individual ...the MTHFR ...
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The Study of MTHFR Gene C677T Polymorphism in Human Embryonic Blastomeres by Fluorescence PCR Method
... Our aim was to investigate MTHFR gene C677T polymorphism in IVF-derived pre-implantation embryos. We highlight here that Only 37 samples among 50 blastomeres were successfully amplified (74%), and the ...
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Hypermethylation in the promoter of the MTHFR gene is associated with diabetic complications and biochemical indicators
... the MTHFR gene with chronic complications of diabetes and the relation of this epigenetic mark with biochemical, inflammatory and oxidative stress ...the gene in question for epigenetic ...
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Original Article Association between single nucleotide polymorphisms of the MTHFR gene and thromboangiitis obliterans
... this gene is the cytosine (C) to thymine (T) sub- stitution at position 677 (rs1801133) in the encoding ...the MTHFR gene (rs1801133, C667T) was associated with susceptibility to TAO through ...
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Influence of MTHFR gene variations on perceived stress modification: Preliminary results of NURSE study
... of MTHFR C677T polymorphism in Exon 4 of MTHFR gene was performed by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) analysis using HINFI digestion, as previous- ly ...
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Methylenetetrahydrofolate Reductase (MTHFR) Gene Mutations in Patients with Idiopathic Scoliosis: A Clinical Chart Review
... Patient charts at a private medical clinic were reviewed for those patients who presented with scoliosis. These patients had been given an option to receive ge- netic testing. Testing was performed via blood, saliva ...
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Polymorphism study of MTHFR 677C?T and its correlation with oxidative stress and their influence on female infertility in Erbil – Iraq Muthanna A. Thabit| Gaylany H. Abdullah | Khalid F. AL-Rawi1
... Oxidative stress is linked to female infertility due to its influence on many causes that lead to female infertility such as PCOS and endometriosis and raised the risk of female infertility. The results show a ...
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Multidisciplinary approach and anesthetic management of a surgical cancer patient with methylene tetrahydrofolate reductase deficiency: a case report and review of the literature
... the MTHFR muta- tion is its association with colorectal cancer and its interference with ...chemotherapy. MTHFR plays an im- portant role in folate metabolism, which has been impli- cated in carcinogenesis ...
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Association of Methylentetraydrofolate Reductase (MTHFR) 677 C > T gene polymorphism and homocysteine levels in psoriasis vulgaris patients from Malaysia: a case-control study
... the MTHFR gene polymorphism and psoriasis vulgaris in the Malaysian population ...between MTHFR C > T gene polymorphism and psoriasis vulgaris in the Malaysian population, which consistent ...
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Detection of Methylene Tetrahydrofolate Reductase Gene Polymorphism (C677T) In Sudanese Patients with Chronic Myeloid Leukemia
... detect MTHFR gene polymorphism (C677T) among Sudanese patients diagnosed with Chronic Myeloid Leukaemia and conducted at the research laboratory of the national center of neurological sciences (NCNS), ...
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Inherited Genetic Markers for Thrombophilia in Northeastern Iran (a Clinical-Based Report)
... (MTHFR) gene C677T, factor V (FV) gene G1691A and prothrombin (PT) gene G20210A polymorphisms to unexplained recurrent early spontaneous abortion were examined ...
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Effects of methionine synthase and methylenetetrahydrofolate reductase gene polymorphisms on markers of one-carbon metabolism
... and MTHFR polymorphisms on HCY, SAM and SAH con- centrations was undertaken in this ...of MTHFR polymorphism on HCY (Ho et ...MTR gene, an A2756G polymorphism has been described resulting in a change ...
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Association of parental methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in couples with unexplained recurrent pregnancy loss
... with MTHFR variant genotype (p < ...of MTHFR polymor- phism significantly increased the risk of RPL by more than three ...in MTHFR gene, leads to a two to threefold higher risk of RPL ...
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RESEARCH ARTICLE Association of methylenetetrahydrofolate reductase gene 677C>T polymorphism with post-stroke depression risk and antidepressant treatment response in Han Chinese
... in MTHFR gene, and an exonic polymorphism, 677C>T is the widest researched ...of MTHFR. In the current literature, the association between MTHFR gene 677C>T polymorphism and ...
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Negative Association of MTHFR C667t Polymorphism with Intracerebral Hemorrhage in Kashmiri Population- An Unexpected Result
... Human MTHFR gene is located on chromosome ...of MTHFR gene is a C-to-T (Cytosine to Thymine) transition at nucleotide 677 (C677T) in exon 4, which results in an alanine (Ala) to valine (Val) ...
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Association Between MTHFR Genetic Variants and Multiple Sclerosis in a Southern Iranian Population
... (SAM). MTHFR gene is polymorphic and two common non-synonymous mutations, C677T (A222V; rs1801133) and A1298C (E429A; rs1801131), have been associated with decreased enzyme activity and the increased levels ...
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The Association of MTHFR C677T and A1298C Polymorphisms with Methotrexate Response and Toxicity in Psoriasis
... In conclusion, our study did not show an association between genotypes of the C677T and A1298C in the MTHFR gene or MTX response and toxicity in psoriatic Thai patients. This finding may be due to the ...
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