Multi-targeted
Novel multi-targeted polymerase chain reaction for diagnosis of presumed tubercular uveitis
... underwent multi-targeted PCR analysis, the sensitivity of multi-targeted PCR was ...of multi-targeted PCR for diagnosis of presumed tubercular uveitis were ...by ...
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ABT-869, a promising multi-targeted tyrosine kinase inhibitor: from bench to bedside
... Neoangiogenesis plays an important role in the pathogen- esis of AML, so targeting VEGF/VEGFR receptors appears to be an alternative approach for treating AML [13]. Based on the early promising clinical trial results in ...
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Dual Epidermal Growth Factor Inhibition and Multi Targeted Epigenetic Therapy (MTET)
... Since the discovery of tyrosine kinase inhibitors in treatment of lung cancer harboring such actionable targets, many lives have been prolonged. To the same extent, same group of patients have failed to benefit from this ...
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The effects of ponatinib, a multi-targeted tyrosine kinase inhibitor, against human U87 malignant glioblastoma cells
... other inhibitors have to be developed. Here, we reported ponatinib, a multi-targeted tyrosine kinase inhibitor, against glioblastoma cells in vitro and in vivo. We demonstrated that ponatinib efficiently ...
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Structure-based virtual screening and molecular docking for the identification of potential multi-targeted inhibitors against breast cancer
... range from −9.8 to −8.9 kcal/mol. Together with this, the common interacting residues that displayed VdW and H-bond with different compounds were Ile752, Leu726, Leu800, Thr798, Ser783, Thr862, Met801, and Asp863, ...
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Epigenetic Tumor Response to Hypoxia: An Epimutation Pattern and a Method of Multi Targeted Epigenetic Therapy (MTET)
... We showed a sensitizing effect of Quercetin on cells, when they were pretreated 6 - 24 hours before exposure to SPB. In this experiment, reduction of dose necessary to inhibit HIF was seen up to 50 percent. We correlated ...
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Massive Intra-Abdominal Imatinib-Resistant Gastrointestinal Stromal Tumor in a 21-Year-Old Male
... a multi- targeted tyrosine kinase inhibitor, can overcome imatinib (IM) resistance caused by diverse genomic mechanisms in patients (pts) with metastatic gastrointestinal stromal tumor (GIST),” Journal of ...
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<p>Midostaurin In Acute Myeloid Leukemia: An Evidence-Based Review And Patient Selection</p>
... nistered multi-targeted tyrosine kinase inhibitor that inhibits multiple kinases including proto-oncogene c-Kit (KIT), pla- telet-derived growth factor (PDGFR)- α /- β , protein kinase C (PKC), spleen ...
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Spotlight on midostaurin in the treatment of FLT3-mutated acute myeloid leukemia and systemic mastocytosis: design, development, and potential place in therapy
... Importantly, full genome sequencing results suggest that AML is initiated by as many as 20 distinct mutations, and the detection of FLT3 mutations in only a subset of AML cells suggests that they may be disease promoting ...
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Synergistic activity of vorinostat combined with gefitinib but not with sorafenib in mutant KRAS human non-small cell lung cancers and hepatocarcinoma
... either multi- targeted kinase inhibitor sorafenib or EGFR-TKI gefitinib on antiproliferative and survival pathways in NSCLC and HCC cells with wild-type EGFR and mutant KRAS in vitro and in ...
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Multi-antigen-targeted chimeric antigen receptor T cells for cancer therapy
... with multi-antigen targeting and combined with the “OR” logic gate to reduce antigen ...Future multi-targeted antigen strategies require more optimized designs and more rational logic gates to ex- ...
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Rural development NGOs and service delivery to the very poor: An empirical analysis of a training center in rural Cameroon
... Targeting services to the very poor has often been used to laud the importance of NGOs as key actors in reducing poverty especially in developing countries. Empirical evidence on this is scarce and at best mixed. This ...
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Human Papillomavirus Genotype Specificity of Hybrid Capture 2 Low Risk Probe Cocktail
... five targeted low-risk genotypes, as well as other, untargeted low-risk and high-risk HPV genotypes, in the hc2 low-risk cocktail-positive samples was determined by using seven different PCR-based genotyping ...
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Complement-targeted therapy: development of C5- and C5a-targeted inhibition
... Thus, the alternative pathway of complement activation is activated in MPO- ANCA-associated nephritis, and a C5a receptor antagonist may be efficacious in treating that nephritis.. The C[r] ...
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The targeted podocyte
... Although mTOR activity was increased in human kidneys with diabetic nephropathy, genetic deletion of podocyte mTORC1 activity via Raptor deletion induced proteinuria and glomerular lesio[r] ...
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M_4.01 C-CLARK.pptx
... • Products that are complex and take customers extended time to make a purchase decision may require personal selling rather than advertising. This is often the case with products targeted to the business market. ...
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Mining Multi-Dimensional Intra and Inter-Association Patterns of Call Records for Targeted Advertising using Multi-Granulation Rough Sets
... discipline, multi-dimensional association patterns generate extra information about associated attribute values in the same ...records, multi- dimensional association patterns with day and time of service ...
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Multi-Relational Data Mining - Free Computer, Programming, Mathematics, Technical Books, Lecture Notes and Tutorials
... ProSafarii primarily focuses on Data Preparation tasks rather than Data Understanding tasks. It supports a collection of transformation rules that it will test against the initial data model, in order to discover ...
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<p>Single- and Multi-Arm Gadolinium MRI Contrast Agents for Targeted Imaging of Glioblastoma</p>
... tumor targeted imaging using polymalic acid-based ...antibody targeted contrast agents, we noticed that the contrast agents displayed prolonged target residing times, which would be unfavorable for repeated ...
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Results of a referral-based weight management program targeted toward children aged 2 to 6 years with obesity or severe obesity
... A total of 55 children (~ 44% male) aged 2 to 6 years provided baseline measurements between April 2012 and February 2014 (Table 1). Approximately 65% of the children were Hispanic with the remaining percentage comprised ...
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