MULTICENTER TRIALS
Comparison of three tests of homogeneity of odds ratios in multicenter trials with unequal sample sizes within and among centers
... in multicenter trials and has not been evaluated in pre- vious studies is the effect of unequal sample size designs on the statistical properties of these homogeneity ...some multicenter clinical ...
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Performance of models for estimating absolute risk difference in multicenter trials with binary outcome
... clinical trials, estimates of RD can be obtained from analysis of a 2×2 table, but regression models are preferable when adjustment is needed for de- sign variables ...In multicenter trials, ...
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Advancing the evidence base in cancer: psychosocial multicenter trials
... of multicenter trials include increased access to partici- pants, the possibility of inclusion of a wider range of popu- lation groups, access to different geographic locations, and the ability to compare ...
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A reinvestigation of recruitment to randomised, controlled, multicenter trials: a review of trials funded by two UK funding agencies
... controlled trials (RCTs) are the gold standard assessment for health ...publicly-funded trials fail to reach their target sample ...in trials funded by the Health Technology Assessment (HTA) program ...
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A reinvestigation of recruitment to randomised, controlled, multicenter trials: a review of trials funded by two UK funding agencies
... of trials recruited their originally specified target sample size, with over three-quarters (78%) recruiting 80% of their ...of trials received an extension of some ...recruit. Trials with 80% power ...
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Onset and progression of diabetes in kidney transplant patients receiving everolimus or cyclosporine therapy: an analysis of two randomized, multicenter trials
... smaller trials using fixed sirolimus dosing [19, 20] or high siro- limus exposure targets [21] did not demonstrate any effect, an analysis of United States Renal Data System data from over 20,000 patients ...
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Exenatide once weekly: clinical outcomes and patient satisfaction
... (AMIGO) trials were three 30-week randomized, triple-blind, placebo-controlled, multicenter trials that had similar design and examined the impact of exenatide treatment on glycemic control in ...
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The Pipeline Embolization Device for the Intracranial Treatment of Aneurysms Trial
... industry-sponsored multicenter trials have failed to demon- strate that any of these technologies have produced a marked incremental improvement in either the safety of the proce- dure, rate of complete ...
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Development of a temperature-controlled phantom for magnetic resonance quality assurance of diffusion, dynamic, and relaxometry measurements.
... for multicenter trials, and the associated repeatability measurements of functional and quantitative imaging protocols across di ff erent MR vendors and field ...
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Biological quality control for cardiopulmonary exercise testing in multicenter clinical trials
... in multicenter trials that included study-wide precision and accuracy in the coupling of mechanical to metabolic power, we applied two different BioQC ...
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Venlafaxine extended release (XR) in the treatment of panic disorder
... dose trials (Liebowitz et al 2004; Bradwejn et al 2005; Ferguson et al 2005) had mean daily doses between ...clinical trials, usually separated from placebo at 4–6 ...
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New drug classes for the treatment of partial onset epilepsy: focus on perampanel
... Perampanel is a white to yellowish white powder with the molecular formula C 23 H 15 N 3 O ⋅ 3/4H 2 O and molecular weight of 362.90. Population pharmacokinetics showed no age effect with exposure. It is administered in ...
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<p>Spotlight on anifrolumab and its potential for the treatment of moderate-to-severe systemic lupus erythematosus: evidence to date</p>
... One of the important contemporary challenges in the management of SLE is developing more effective drugs on the grounds of the lack of ef fi cient targeted therapies to treat the heterogeneous SLE manifestations. For 60 ...
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Bapineuzumab for mild to moderate Alzheimer’s disease in two global, randomized, phase 3 trials
... Despite early termination, these studies in a more global population demographic confirm the overall negative clinical findings of the first phase 3 trials of bapineuzumab in mild to moderate AD. Some biomarker ...
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Profile of secukinumab in the treatment of psoriasis: current perspectives
... clinical trials have demonstrated the effectiveness of secukinumab in the treatment of moderate-to-severe plaque psoriasis, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, and noninfectious ...
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Serotonin receptor modulators in the treatment of irritable bowel syndrome
... double-blind, multicenter study of 1519 women tegaserod 6 mg BID for 12 weeks produced signifi cant improvements in the Subject’s Global Assessment of Relief compared to ...tive, multicenter study from ...
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The Role of Functional Dopamine Transporter SPECT Imaging in Parkinsonian Syndromes, Part 1
... This is reflected in 2 large multicenter clinical trials that used 123I--CIT SPECT, which found that up to 15% of patients diagnosed as having PD had normal DaT-SPECT study findings cla[r] ...
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Multicenter Outbreak of Infections by Saprochaete clavata, an Unrecognized Opportunistic Fungal Pathogen
... Multicenter Outbreak of Infections by Saprochaete clavata, an Unrecognized Opportunistic Fungal Pathogen Multicenter Outbreak of Infections by Saprochaete clavata, an Unrecognized Opportunistic Fungal[.] ...
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Gene expression profiling of immunomagnetically separated cells directly from stabilized whole blood for multicenter clinical trials
... Computational methods offer alternatives to physical cell separation. However, changes in cell composition and microenvironmental changes may represent obstacles towards the investigation of gene expression changes ...
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Evaluating joint space narrowing and cartilage loss in rheumatoid arthritis by using MRI
... two multicenter randomized, controlled trials (24 patients from IMPRESS (Impact of Rituximab on Magnetic Resonance Imaging Evidence of Synovitis and Bone Lesions in Patients With Moderate or Severe ...
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