multidrug resistance
Multidrug Resistance in Fungi
... drug resistance (reviewed in references 79 and ...in multidrug resistance has been ob- scured by their better-publicized ...to resistance to the antifungal agent fluconazole, as well as ...
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Ovarian hormones modulate multidrug resistance transporters in the ovary
... drug Resistance Transporters (MDRs) could further our understanding of the mechanism by which these trans- porters function to protect the ovary from xenobiotics and ...toxicants. Multidrug ...
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Detection approaches for multidrug resistance genes of leukemia
... These resistance mechanisms include: a) increased drug metabolism due to altered molecular targets; b) defective apoptotic machinery; c) over-expression of efflux pumps, such as P-glycoprotein (P-gp), ...
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Targeting multidrug resistance in cancer by natural chemosensitizers
... Although the general term cancer covers many differ- ent diseases, most types of cancers share a common fea- ture of not acting to available chemotherapies through development of multidrug resistance (MDR). ...
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Yeast ABC proteins involved in multidrug resistance
... tumor resistance), but also increase the risk of Parkinson’s disease and ulcerative colitis ...tumor resistance to anticancer drugs are BCRP (breast cancer resistance protein) and MRP1-3 and 5 ...
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ELM1 Is Required for Multidrug Resistance in Saccharomyces cerevisiae
... the multidrug resistance of pdr1-3, exhibited elongated bud morphology and impaired PDR5 transcription (without affecting Pdr1-independent transcription) and abolished cellular doxorubicin elim- ...of ...
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Natural Products Modulate the Multifactorial Multidrug Resistance of Cancer
... reverse multidrug resistance (MDR1) in leukemia and human colon car- cinoma, which endogenously expresses ...doxorubicin resistance in both cell lines ...
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Comparative Genomics for the Elucidation of Multidrug Resistance in Candida lusitaniae
... with resistance to amphotericin B (AmB) ...candin resistance in ...days. Resistance was associated with a missense mutation (S645F) in the FKS1 gene encoding 1,3-  -glucan synthase, the target of ...
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Stimuli-Responsive Nanomedicines for Overcoming Cancer Multidrug Resistance
... Chemotherapy is still a main option for cancer therapy, but its efficacy is often unsatisfying due to multidrug resistance (MDR). The tumor microenvironment is considered a dominant factor causing MDR. ...
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Lapatinib Antagonizes Multidrug Resistance-Associated Protein 1-Mediated Multidrug Resistance by Inhibiting Its Transport Function
... for multidrug resistance (MDR) in ...on multidrug resistance–associated protein 1 (MRP1 [ABCC1]), MRP2 (ABCC2), MRP4 (ABCC4) and lung rela- tive resistance protein (LRP) drug efflux ...
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Expression and clinical significance of multidrug resistance proteins in brain tumors
... many anticancer drugs are highly lipophilic and rela- tively small, the permeation level of those drugs across the BBB is unexpectedly low [3]. This can be partially explained by the expression of P-glycoprotein (P-gp) ...
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ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal
... is resistance against anticancer ...primary resistance or natural resistance in which they do not respond to standard chemotherapy drugs from the ...acquired resistance later. Experimentally, ...
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Descriptive Epidemiology of Multidrug Resistance Tuberculosis (MDR TB) in Bangladesh
... sain, M.M., Zaman, S., Marma, B., Ahsan, G.U., Uzzaman, M.R., Hossain, A. and Hawlader, M.D.H. (2018) Descriptive Epi- demiology of Multidrug Resistance Tuber- culosis (MDR-TB) in Bangladesh. Journal of ...
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Molecular Modelling of Human Multidrug Resistance Protein 5 (ABCC5)
... Multidrug resistance protein 5 (MRP5/ABCC5) is a 161 kDa member of the super family of ATP- binding cassette (ABC) superfamily of transmembrane transporters that is clinically relevant for its ability to ...
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Function and membrane targeting of the multidrug resistance associated protein 2
... Analysis of expression of cMOAT MRP2, MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene MRPl, in human cancer cell lines.. Expression of human MRP6, a [r] ...
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Trametinib modulates cancer multidrug resistance by targeting ABCB1 transporter
... Overexpression of adenine triphosphate (ATP)-binding cassette (ABC) transporters is one of the main reasons of multidrug resistance (MDR) in cancer cells. Trametinib, a novel specific small-molecule ...
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The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer
... because multidrug resistance (MDR) problem in the primary tumor usually leads to treatment ...drug resistance, and MDR protein family plays an essential ...cross-over resistance to drug of ...
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Gene cassettes of class I integron-associated with antimicrobial resistance in isolates of Citrobacter spp. with multidrug resistance
... among multidrug resistance of Enterobac- teriaceae isolates ...carry resistance to several antimicrobial agents in ...for resistance to fluoroquinolones, β-lactams, aminoglycosides, ...
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Doxorubicin-transferrin conjugate selectively overcomes multidrug resistance in leukaemia cells
... overcome multidrug resistance ...a multidrug-resistant leukaemia cell line (HL60ADR) and a normal tissue cell line (human ...the multidrug-resistant cell ...
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Functional study of the novel multidrug resistance gene HA117 and its comparison to multidrug resistance gene 1
... the multidrug resistance strength of HA117 is similar to that of ...strong multidrug resistant novel gene and much importance should be given to ...drug resistance in tumor cells in ...
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