multidrug resistance protein 2
Membrane transport of camptothecin: facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2)
... the multidrug resistance phenomenon have been conducted in cancer ...lower resistance levels compared with typical MDR compounds suggests that the positive charge is probably not an absolute ...
12
INFLUENCE OF MULTIDRUG RESISTANCE PROTEIN-2 GENETIC POLYMORPHISM ON THE PHARMACOKINETICS OF MYCOPHENOLATE MOFETIL IN THAI KIDNEY TRANSPLANT PATIENTS
... SNPs leading to altered MRP-2 activity might influence this process and therefore affect MPA exposure. [10,11] The most extensive study was a SNP that involved a C to T transition at position -24 on promoter ...
6
Molecular surveillance of artemisinin resistance falciparum malaria among migrant goldmine workers in Myanmar
... Drug resistance is one of the challenges to success- fully achieving this goal ...artemisinin resistance along with appropriate action to eliminate resistant strains is important in successfully contain- ...
8
Expression of Multidrug Resistance ATP Binding Cassette (ABC) Transporters in Canine Mammary Tumors
... 2000 Increased Expression of an ATP-Binding Cassette Superfamily Transporter, Multidrug Resistance Protein 2, in Human Colorectal Carcinomas.. and Gerlach, J.H.[r] ...
9
A multidrug resistance protein (MRP) like transmembrane pump is highly expressed by resting murine T helper (Th) 2, but not Th1 cells, and is induced to equal expression levels in Th1 and Th2 cells after antigenic stimulation in vivo
... clone (secreting IL-4, IL-5, and IL-6, but not IL-2 or IFN- g ) able to efflux free anionic Fluo-3 from the cell using an energy- dependent transport system for organic anions (3). Dye extru- sion was prevented by ...
9
Lapatinib Antagonizes Multidrug Resistance-Associated Protein 1-Mediated Multidrug Resistance by Inhibiting Its Transport Function
... In this study, we established the C-A120–inoculated nude mice xenograft model. Athymic nude mice (5–6 wks old) were purchased from the center of exper- imental animals (Sun Yat-sen University). Briefly, each nude mouse ...
10
The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer
... H 2 O 2 in methanol for 10 min to prevent any nonspecific ...1, 2 and 3 ...as 2; 50-75% were recorded as 3; >75% were recorded as ...(-); 2-3 (+); 4-5 (++); 6-7 ...
6
Expression of LRP and MDR1 in locally advanced breast cancer predicts axillary node invasion at the time of rescue mastectomy after induction chemotherapy
... encoding multidrug resistance associated protein (MDR1) and lung cancer associated resistance protein (LRP) in formalin-fixed, paraffin-embedded tumor samples from 52 patients treated ...
9
Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance
... G418 resistance marker (27), with their associated stop codons, 16 bp downstream of the start codon of ...Both resistance markers were flanked by 510 bp of pfcarl promoter sequence at the 5= end and 871 bp ...
13
Expression of multidrug resistance proteins is localized principally to the Malpighian tubules in larvae of the cabbage looper moth, Trichoplusia ni
... rate of 2.5-fold and measured in triplicate. From the resulting standard curves, a correction for gene amplification efficiency was applied by importing standard curve data into each subsequent data- set generated. ...
8
The cloning and characterisation of a multidrug resistance associated protein (MRP) from wheat
... Sequence comparisons between TaMRP2 and other MRP subfamily members suggested that TaMRP2 may function as a GS-X pump, and therefore play a role in xenobiotic detoxification. Expression and functional data were required ...
204
ATP-binding cassette (ABC) transporters in normal and pathological lung
... the multidrug resistance-associ- ated protein 1 (MRP1) were initially detected in tumour cell ...so-called multidrug resistance ...
16
Molecular Modelling of Human Multidrug Resistance Protein 5 (ABCC5)
... ABCC5 protein using different templates and sub- jecting models so obtained for structural validation using different analysis tools like PROCHECK, ProSA and ...
13
Selection of a Multidrug Resistance Plasmid by Sublethal Levels of Antibiotics and Heavy Metals
... the resistance plasmid is balanced by the selective effect of the added drug (1, ...regulatory protein, is essential for conjugation since it controls the expression of the transfer genes of the plasmid ...
9
Multidrug Intrinsic Resistance Factors in Staphylococcus aureus Identified by Profiling Fitness within High Diversity Transposon Libraries
... FIG 2 Tn-Seq results were validated by testing mutant fitness in spot dilution ...surface protein of undetermined function; graR is a member of a multicom- ponent sensing system (MCS); mprF and dltA are ...
11
Function and membrane targeting of the multidrug resistance associated protein 2
... Analysis of expression of cMOAT MRP2, MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene MRPl, in human cancer cell lines.. Expression of human MRP6, a [r] ...
198
Multidrug Resistance in Neisseria gonorrhoeae: Identification of Functionally Important Residues in the MtrD Efflux Protein
... modified resistance profiles of our MtrD mutants, molecular docking of seven diverse MtrD substrates (progesterone, nonoxynol-9, azithromycin, rifampin, ethidium, crystal violet, and cholic acid) and the PA  N ...
14
Original Article microRNA-497 induces cell apoptosis by negatively regulating Bcl-2 protein expression at the posttranscriptional level in human breast cancer
... Bcl-2 protein expression in breast cancer ...Bcl-2 protein expression but had no impact on mRNA expression of ...Bcl-2 protein expression at the posttranscriptional ...
11
Comparative Genomics for the Elucidation of Multidrug Resistance in Candida lusitaniae
... lusitaniae protein data set was downloaded at ...These protein sequences were used as protein evidence during structural ...and protein sequences described above were used as evidence to aid ...
22
Multi drug resistance and extended spectrum beta lactamase producing Gram negative bacteria from chicken meat in Bharatpur Metropolitan, Nepal
... The prevalence of Salmonella spp. was 26.2% which is similar to the studies carried out in USA and South Korea [13, 19]. In contrast, higher prevalence rate of Salmo- nella spp. was found in Southern Thailand (67.5%) ...
5