Multivesicular Bodies
Subviral Hepatitis B Virus Filaments, like Infectious Viral Particles, Are Released via Multivesicular Bodies
... cient HBV mutant (Fig. 4A). Unfortunately, using this approach makes it difficult to directly identify impressive filaments based on their shape, since they must be oriented in parallel to the section plane in the MVBs. ...
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The Tegument Protein UL71 of Human Cytomegalovirus Is Involved in Late Envelopment and Affects Multivesicular Bodies
... enlarged multivesicular bodies (MVBs) were found in close proximity to the viral assembly compartment, suggesting that pUL71 affects MVBs during virus ...
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Coxsackievirus A9 Infects Cells via Nonacidic Multivesicular Bodies
... in multivesicular structures 2 h postinfection ...of multivesicular bodies (MVBs) is crucial for promoting infection, as judged by the strong inhibitory effect of the wild-type form of Hrs and ...
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Intracellular Trafficking and Maturation of Herpes Simplex Virus Type 1 gB and Virus Egress Require Functional Biogenesis of Multivesicular Bodies
... The biogenesis of multivesicular bodies (MVBs) is topologically equivalent to virion budding. Hence, a number of viruses exploit the MVB pathway to build their envelope and exit from the cell. By expression ...
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Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV 1
... Finally, these functions of Nef were reproduced in primary macrophages, where the wild type but not mutant Nef proteins led to increased release of new viral particles from infected cell[r] ...
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Multivesicular Bodies as a Platform for Formation of the Marburg Virus Envelope
... The Marburg virus (MARV) envelope consists of a lipid membrane and two major proteins, the matrix protein VP40 and the glycoprotein GP. Both proteins use different intracellular transport pathways: GP utilizes the ...
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Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology
... Accumulation of α -syn occurs in neurons and astrocytes Next, we sought to further characterize the mechanisms DLB-derived exosomes utilize to potentially trigger α- syn pathology using immunofluorescent colabeling tech- ...
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Genetic Analysis of hook, a Gene Required for Endocytic Trafficking in Drosophila
... The Drosophila hook gene encodes a novel component of the endocytic compartment. Previously identi- fied hook alleles, which still expressed truncated Hook proteins, affected the accumulation of internalized ...
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Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells
... The physiological function of tau is to stabilize microtu- bules which are essential for proper intracellular traffick- ing [20]. Thus, to further explore N279K-mediated defects in NSCs, we probed for lipid raft marker ...
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Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia
... from multivesicular bodies to lysosomes, resulting in intracellular accumulation of undegraded c-KIT that was accompanied by enhanced activation of ERK and increased cell ...
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Emerging role of extracellular microRNAs and lncRNAs
... endosome/multivesicular bodies (MVBs) and intralum- inal vesicles (ILVs), that upon exocytosis are released as exosomes, which is also called the endolysosomal path- way [21, ...
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Exosomes derived from mesenchymal stem cells inhibit neointimal hyperplasia by activating the Erk1/2 signalling pathway in rats
... endosomal bodies of cells; endosomes bud inward to form multivesicular bodies (MVBs), which are then fused with the plasma membrane and released into inner vesicles ...
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Trafficking routes to the plant vacuole: connecting alternative and classical pathways
... Jaillais Y, Santambrogio M, Rozier F, Fobis-Loisy I, Mi•ge C, Gaude T. 2007. The retromer protein VPS29 links cell polarity and organ initiation in plants. Cell 130, 1057Ð1070. Jia T, Gao C, Cui Y, Wang J, Ding Y, Cai Y, ...
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Internalization of type 1 complement receptors and de novo multivesicular body formation during chemoattractant induced endocytosis in human neutrophils
... Upon activation of human neutrophils by chemoattractants, functionally important proteins are rapidly transported from intracellular granules and storage vesicles to the plasma membrane. This is accompanied by a marked ...
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The small vesicular culprits: the investigation of extracellular vesicles as new targets for cancer treatment
... form multivesicular bodies ...Apoptotic bodies are several microm- eters in diameter (800–5000 nm) and are released from the cell undergoing programmed cell ...
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The body as a form of representation
... look at the points of possible intersection and rupture between the positions of the student as social subject and the student as dramatic subject, or, the social actor and the dramatic actor. Whatever the similarities ...
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Myth (un)making : the adolescent female body in mythopoeic YA fantasy
... fantasy—offers bodies that express multiplicity and difference, thereby offering frameworks for living and being a body that challenge the dominant, hegemonic fantasy of ...
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Racing bodies
... the weight requirement of 60 kg on its website (BRS 2011). Very low body weight is particularly required in Flat racing where horses are raced as juveniles whose bodies are not fully developed. In order to avoid ...
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Racing bodies
... This chapter identifies a group of workers, sports support workers, whose labour processes have, so far, been less theorised in the literature than those of sports(wo)men (Wacquant 1995). In studying stable staff, we can ...
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Nuclear dynamics: where genes are and how they got there
... nuclear bodies as a way of modulating their func- ...nuclear bodies will reveal marked changes either in diffusion rates, or in constrained volumes, as they undergo transitions from freely diffusing to ...
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