Murine gammaherpesvirus-68
Selective Uptake of Small RNA Molecules in the Virion of Murine Gammaherpesvirus 68
... Noncoding RNAs are a feature of many herpesvirus genomes. They include microRNAs, whose function is the subject of intense investigation, in addition to longer RNA molecules such as the Epstein-Barr virus-encoded RNAs ...
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Cytokine production in the immune response to murine gammaherpesvirus 68.
... Murine gammaherpesvirus 68 (MHV-68) is a naturally oc- curring rodent pathogen (1) which, from the structure of the viral genome and limited sequence data, appears to be closely related to ...
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Role of CXCR3 in the Immune Response to Murine Gammaherpesvirus 68
... of murine gammaherpesvirus 68 (MHV-68) results in acute productive infection of lung alveo- lar epithelial cells and a latent infection in several cell types (7, 17, 19, ...
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Gamma interferon is not essential for recovery from acute infection with murine gammaherpesvirus 68.
... Murine gammaherpesvirus 68 (MHV-68) is a naturally oc- curring rodent pathogen (2) which is closely related to Epstein- Barr virus, human herpesvirus 8, and herpesvirus saimiri ...
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ZAP Inhibits Murine Gammaherpesvirus 68 ORF64 Expression and Is Antagonized by RTA
... Zinc finger antiviral protein (ZAP) is an interferon-inducible host antiviral factor that specifically inhibits the replication of cer- tain viruses, including HIV-1 and Ebola virus. ZAP functions as a dimer formed ...
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Complete sequence and genomic analysis of murine gammaherpesvirus 68.
... Murine gammaherpesvirus 68 ( g HV68) infects mice, thus providing a tractable small-animal model for analysis of the acute and chronic pathogenesis of ...in gammaherpesvirus biology via ...
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Rta of Murine Gammaherpesvirus 68 Reactivates the Complete Lytic Cycle from Latency
... questions. Murine gammaherpesvirus 68 (MHV-68, or ␥ HV68) can establish de novo lytic infection in a variety of cell lines and is also able to infect laboratory mice, offering an ideal model ...
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Kinetics of Murine Gammaherpesvirus 68 Gene Expression following Infection of Murine Cells in Culture and in Mice
... The human pathogens Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV-8) are members of the Gammaherpesviri- nae subfamily, which also includes murine gammaherpesvirus 68 (MHV-68) and ...
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Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication
... Latency-associated nuclear antigen (LANA) is a conserved, multifunctional protein encoded by members of the rhadinovirus subfamily of gammaherpesviruses, including Kaposi sarcoma-associated herpesvirus (KSHV) and ...
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Role for MyD88 Signaling in Murine Gammaherpesvirus 68 Latency
... for murine gammaherpesvirus 68 (MHV68), we investi- gated the role of TLR signaling in the establishment and maintenance of MHV68 latency in ...
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The Murine Gammaherpesvirus 68 v-Cyclin Is a Critical Regulator of Reactivation from Latency
... Gamma-2 herpesviruses encode a homolog of mammalian D-type cyclins. The v-cyclin encoded by murine gammaherpesvirus 68 ( ␥ HV68) induces cell cycle progression and is an oncogene (L. F. van Dyk, J. ...
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Lack of Heparan Sulfate Expression in B-Cell Lines: Implications for Kaposi's Sarcoma-Associated Herpesvirus and Murine Gammaherpesvirus 68 Infections
... a gammaherpesvirus associated with both lymphoid and nonlymphoid cell tumors in humans, mostly in immunodeficient ...range. Murine gammaherpesvirus 68 (MHV68) is phylo- genetically related to ...
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Murine Gammaherpesvirus 68 Encodes a Functional Regulator of Complement Activation
... the murine gammaherpesvirus 68 ( ␥ HV68) genome revealed an open reading frame (gene 4) which is homologous to a family of proteins known as the regulators of complement activation (RCA proteins) ...
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De Novo Infection of B Cells during Murine Gammaherpesvirus 68 Latency
... that gammaherpesvirus ( ␥ HV) latency in infected humans is perpetuated by a combination of infected cell proliferation and periodic de novo infections af- ter ...with murine ...
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Identification and Analysis of Expression of Novel MicroRNAs of Murine Gammaherpesvirus 68
... Murine gammaherpesvirus 68 (MHV-68) is closely related to Epstein-Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV) and provides a small-animal model with which to study the ...
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Identification and characterization of murine gammaherpesvirus 68 gp150: a virion membrane glycoprotein.
... Murine gammaherpesvirus 68 (MHV-68) is a pathogen of murid rodents and was first isolated from Clethrionomys glareo- lus (bank vole) in Slovakia (3, 4, ...a gammaherpesvirus on the ...
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ORF30 and ORF34 Are Essential for Expression of Late Genes in Murine Gammaherpesvirus 68
... A hallmark of productive infection by DNA viruses is the coupling of viral late gene expression to genome replication. Here we report the identification of open reading frame 30 (ORF30) and ORF34 as viral trans factors ...
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Murine Gammaherpesvirus 68 Reactivation from B Cells Requires IRF4 but Not XBP-1
... the gammaherpesvirus family is the link between viral reactivation from latently infected B cells and plasma cell ...the murine gammaherpesvirus 68 (MHV68) RTA promoter in vitro, consistent ...
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Murine Gammaherpesvirus 68 Contains Two Functional Lytic Origins of Replication
... Murine gammaherpesvirus 68 (MHV-68) is a member of the gammaherpesvirus subfamily and is closely related to Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein-Barr vi- ...
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Function of Rta Is Essential for Lytic Replication of Murine Gammaherpesvirus 68
... Rta, encoded primarily by open reading frame 50, is well conserved among gammaherpesviruses. It has been shown that the Rta proteins of Epstein Barr virus (EBV), Kaposi’s sarcoma-associated herpesvirus (KSHV, or HHV-8), ...
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