Mutant mice
Genes and signaling pathways involved in memory enhancement in mutant mice
... are mutant mice that show enhanced LTP without changes in behavior, or even with deficits in learning and memory (Table ...knockout mice showed severe deficits in spatial learning and memory, whereas ...
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Standardized, systemic phenotypic analysis of Slc12a1I299F mutant mice
... I299F mutant mice were examined using a systemic and standardized, comprehensive phenotypic analysis at the age of 14–26 ...knockout mice [23] as well as in our previous publication of line Slc12a1 ...
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Lmod2 piggyBac mutant mice exhibit dilated cardiomyopathy
... Background: Leiomodin proteins, Lmod1, Lmod2 and Lmod3, are key regulators of the thin filament length in muscles. While Lmod1 is specifically expressed in smooth muscles, both Lmod2 and Lmod3 are expressed in striated ...
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Igf2 Gene Expression Levels in Wild-Type and Mutant Mice
... wild-type mice during development and is altered in several mutant mice bearing deletions at the Igf2/H19 ...all mice analyzed, except in ΔU2/Dom mutant mice where P0 and P1 ...
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Molecular and Phenotypic Analysis of Attractin Mutant Mice
... Atrn mutant mice is caused by a central process leading to increased energy expenditure, and demonstrate that pigmentation is more sensitive to levels of Atrn mRNA than are nonpigmentary ...
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Impaired learning and memory in CD38 null mutant mice
... 27]. Mutant mice with impaired LTP often show deficits in hippocampus- dependent learning and memory [26, ...− mice showed comparable level of early-phase LTP (E-LTP) induced by a single pulse of ...
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No evidence for cardiac dysfunction in Kif6 mutant mice.
... A KIF6 variant in man has been reported to be associated with adverse cardiovascular outcomes after myocardial infarction. No clear biological or physiological data exist for Kif6. We sought to investigate the impact of ...
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Neuronal cilia and appetite regulation in Alms1 mutant mice
... (Alms1 mutant) ...in mice also produces an obese phenotype with high serum leptin levels, reduced hypothalamic POMC mRNA levels but unchanged NPY and AgRP mRNA ...foz/foz mice. Since foz/foz ...
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Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice
... The mutant p53 protein contributes to transformation, metastasis and drug ...of mutant p53 can be found in tumours and the accumulation of mutant p53 has previously been reported in pathologically ...
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Deletion and Interallelic Complementation Analysis of Steel Mutant Mice
... function of Mgf. While the entire Mgfcoding region is deleted in SId' DNA, this allele contains the smallest deletion of the lethal alleles examined and is least likely to[r] ...
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Specificity and plasticity of thalamocortical connections in Sema6A mutant mice
... To determine whether the initial derailment of dLGN axons could affect the general topographical arrangement between neocortex and thalamus, we performed multiple cortical dye placements at E16.5 and P0. We placed DiI ...
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Abnormalities in brain structure and behavior in GSK-3alpha mutant mice
... 18) mice were places in novel environ- ment chamber for 3 min (conditioning stimulus, CS), where they received one electrical foot shock (unconditioning stimulus, US; shock intensity = ...later mice were ...
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The mechanism of neuropathy in peripheral myelin protein 22 mutant mice
... Human duplication patients have a greatly reduced myelinated fibre density from an early age (10 y) (Gabreëls-Festen et al. 1995; Thomas et al. 1997; Fabrizi et al. 1998). Although our results show no difference in fibre ...
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Retinaldehyde dehydrogenase 2 and Hoxc8 are required in the murine brachial spinal cord for the specification of Lim1+ motoneurons and the correct distribution of Islet1+ motoneurons
... conditional mutant mice A conditional Raldh2 allele (Raldh2 L2 ) was obtained (Vermot et ...L2/- mice (hereafter called Raldh2 L–/– ) were obtained at a Mendelian ratio and had a normal life span, ...
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Assembly of the cochlear gap junction macromolecular complex requires connexin 26
... CX26-mutant mice did not show GJPs at many of the cell borders, although a part of the cells showed significantly shorter GJPs compared with the those of controls (Supplemental Figure ...R75W+ mice ...
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Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes
... null mutant mice by gene targeting, we produced double mutant mice homozygous for both Agtr1a and Agtr1b null mutation (Agtr1a-/-; Agtr1b-/-) by mating the single gene ...Agtr1b-/- mice ...
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Overcoming the Dominant Negative Effect of Mutant p53+/R172H Mice.
... the mutant p53 has a dominant negative effect over the remaining wild type allele in cells with one mutant and one wild type p53 allele (p53 +/Mut ) [176, 181, ...the mutant p53 proteins oligomerize ...
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Salt inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling
... 4-week-old mice were sub- jected to bone histomorphometric analysis. The mice were given calcein (20 mg/kg by ...SIK2/3 mutant mice, we chose to normalize parameters to tissue area rather than ...
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Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis
... a mutant mouse that spontaneously develops pruritic dermatitis as the result of an initial defect in skin homeostasis that is followed by induction of a Th2-biased immune ...These mice harbor a mutation ...
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From mice to men: lessons from mutant ataxic mice
... between mice and ...transgenic mice carry human pathological alleles and thus they can be used as models for specific human ...transgenic mice the ac- tion of the mutation could significantly differ ...
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