Mutation in the Mitochondrial Genome
Chorea ballism as a dominant clinical manifestation in heteroplasmic mitochondrial encephalopathy, lactic acidosis, and stroke like episodes syndrome with A3251G mutation in mitochondrial genome: a case report
... (3) mitochondrial myopathy evident by lactic acidosis and/or ragged red ...lactate, mitochondrial abnormalities in muscle biopsy, and a MELAS-related gene mutation) ...point mutation: ...
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The “fossilized” mitochondrial genome of Liriodendron tulipifera: ancestral gene content and order, ancestral editing sites, and extraordinarily low mutation rate
... To scale the substitutions per site to absolute substitution rates, a chronogram was estimated using the same 13 taxa and a concatenated three-plastid-gene alignment (3,936 bp) with BEAST ver. 1.61 [87] and the following ...
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Transformation of the mitochondrial genome
... the mutation did not prevent the assembly of the 950-kDa whole complex I that conserves nearly all the NADH dehydrogenase activity of the peripheral arm, but the NADH:duroquinone oxidoreductase activity was ...
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Mitochondrial genome changes and neurodegenerative diseases
... mtDNA mutation could be in energetic disadvantage and replaced during the lifespan of an individual ...human mitochondrial DNA. Color codes represent: Grey, the two mitochondrial rRNAs; Yellow, the ...
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Mitochondrial Genome Sequence Evolution in Chlamydomonas
... The mitochondrial genomes of the Chlorophyta exhibit significant diversity with respect to gene content and genome compactness; however, quantitative data on the rates of nucleotide substitution in ...
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Maintenance of Mitochondrial Morphology Is Linked to Maintenance of the Mitochondrial Genome in Saccharomyces cerevisiae
... of mitochondrial DNA migration to the nucleus, carbon-source-dependent alterations in mitochondrial morphology, and increased rates of mitochondrial DNA ...requiring mitochondrial respiration, ...
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Mitochondrial Genomics: structure, inheritance and phylogenetic utility of the Mitochondrial genome in Bivalvia and Insecta
... Although the discovery of sex-related heteroplasmy has not been surprising for a mytilid, one trait of Musculista DUI system were seemed to be unique, contrasting with all previously described DUI systems above reported: ...
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Diagnosis of mitochondrial disorders by concomitant next-generation sequencing of the exome and mitochondrial genome
... and mitochondrial genomes potentially ...and mitochondrial genomes to obtain a molecular diagnosis for four patients with three distinct mitochondrial ...a mutation in MT-ATP6, two affected ...
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Mitochondrial genome diversity and evolution in Branchiopoda (Crustacea)
... directional mutation bias during lineages’ evolution may significantly affect substitution ...GC-biased mutation rate would speak in favour of an increase of the substitution rate in Anostraca and ...
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Mitigating Mitochondrial Genome Erosion Without Recombination
... transmit mitochondrial genes uniparentally, often without recombination among genetically divergent ...the genome susceptible to Muller’s ...effect. Mitochondrial fusion –fi ssion cycles ensure ...
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Mitigating mitochondrial genome erosion without recombination
... deleterious mutation load or the spread of sel sh genetic ...maintaining genome quality across levels of selection arise as part of the transition, and become seamlessly integrated within organism life ...
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Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized.
... mtDNA mutation- speci fic complementary RNAs were shown to specifically stall mutant mtDNA replication and shift heteroplasmy [94,95] ...for mitochondrial import of RNA ...mammalian mitochondrial RNA ...
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Organization of the Large Mitochondrial Genome in the Isopod Armadillidium vulgare
... nonstoichiometric ratio of copies between dimer and H. littoralis may have two linear molecules whose ratio monomer, with one of the molecular forms (linear remains constant through transmission (Warrior and monomer or ...
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A Mutation in the Mitochondrial Fission Gene Dnm1l Leads to Cardiomyopathy
... Genome-wide low-resolution mapping was performed using DNA samples from 15 N 2 C3H/HeH backcross animals that were identified as carriers based on the development of congestive heart failure. Genomic DNA samples ...
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A Cluster of Metabolic Defects Caused by Mutation in a Mitochondrial trna
... components of the metabolic syndrome. The variation in the phenotypic consequences of this homoplasmic mitochondrial mutation is striking. Hypomagnesemia, hypertension, and hypercholesterolemia each show ...
A Cytoplasmic Suppressor of a Nuclear Mutation Affecting Mitochondrial Functions in Drosophila
... and mitochondrial DNA ...of mitochondrial disease patients bearing the same primary mutation, whether in nuclear or mitochondrial DNA, have been attributed to putative genetic determinants ...
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Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability
... in mitochondrial R-loop processing and regulation, acting as a guardian of mitochondrial genome ...compromise genome integrity by interfering with DNA replication ...and mitochondrial ...
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Mitochondrial genome variation of Atlantic cod
... complete mitochondrial DNA sequence of 124 cod specimens from the eastern and western part of the species’ distribution range in the North Atlantic ...cod mitochondrial genomes did not reveal a clear ...of ...
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The Mitochondrial Genome of the Brachiopod Laqueus rubellus
... The genome has an overall gene arrangement drastically different from that of any other organisms so far reported, but contains several short segments, composed of 2–3 genes, which are found in other mt ...mt ...
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Unraveling selection in the mitochondrial genome of Drosophila.
... Tests of neutrality: To investigate protein evolution we compared the number of amino acid replacement substitu- tions to synonymous substitutions in cytochrome b (MCDON[r] ...
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