Mutual prodrug
Mutual prodrug concept: Fundamentals and applications
... design.’ Mutual prodrug is a type of carrier-linked prodrug, where the carrier used is another biologically active drug instead of some inert ...A mutual prodrug consists of two ...
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“Synthesis of Mannich Bases of Thiosemicarbazide as Mutual Prodrug and In-Vitro Screening for Anti-Infective Activity” by Sachin A Pishawikar, Harinath N More, India.
... using mutual prodrug concept, first mannich bases were synthesized using aldehyde, ketones and secondary amines with aliphatic, aromatic, cyclic and heterocyclic nature using mannich reaction and then ...
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Evaluation of glycine-bearing celecoxib derivatives as a colon-specific mutual prodrug acting on nuclear factor-κB, an anti-inflammatory target
... Abstract: In an inflammatory state where HOCl is generated, glycine readily reacts with HOCl to produce glycine chloramine, an anti-inflammatory oxidant. Colonic delivery of celecoxib elicits anticolitic effects in a ...
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CHEMISTRY OF β-LACTAM SULTAMICILLIN AS A MUTUAL PRODRUG OF AMPICILLIN AND SULBACTAM WORKS AS AN AZABICYCLO [3.2.0] HEPTANE CARBOPENAM BIOPRECURSOR
... Sultamicillin is a mutual prodrug of ampicillin and sulbactam. Ampicillin, a semi-synthetic orally active broad spectrum antibiotic, is linked via a methylene group with a β-lactamase inhibitor. ...
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EXPLORING THIOESTER CHEMISTRY IN MUTUAL PRODRUG DESIGN FOR COMBINATION ANTIHYPERTENSIVE THERAPY
... linked mutual prodrug of captopril and furosemide as a combination ...thioester prodrug FC was synthesized and characterized by spectral ...the mutual prodrug exhibited improved ...
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Synthesis, hydrolysis studies and pharmacodynamic profile of novel colon specific mutual prodrug of Aceclofenac with amino acids
... Anti-inflammatory activity [15]: The anti-inflammatory activity of synthesized prodrugs was determined by hind paw edema method utilizing carrageen as phlogistic agent (0.1 ml, 1%). The initial volume of right hind paw ...
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Mutual Amide Prodrug of Etodolac-glucosamine: Synthesis, Characterization and Pharmacological Screening
... The synthesis of mutual prodrug (EC‑GLU) was performed in three steps (fig. 1). First step deals with activation of carboxylic acid functional group of EC (10 mol/ml) by using DCC (10 mol/ml) in ethanol at ...
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PRODRUG DESIGN: AN OVERVIEW
... where the carrier used is another biologically active drug instead of some inert molecule. A mutual prodrug consists of two pharmacologically active agents coupled together so that each acts as a promoiety ...
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PRODRUG AS A NOVEL APPROACH OF DRUG DELIVERY- A REVIEW
... metabolites. Mutual prodrugs of EB with PAS (PE), PAS with PAS (PP) and INH with PAS (PI) were synthesized and ...these mutual prodrug conjugates do not hydrolyze appreciably and are absorbed ...PP. ...
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Carriers for Prodrug Synthesis: A Review
... In an ideal situation, the carrier should not have intrinsic toxicity. The carrier should also be non- antigenic and non-immunogenic, and should not accumulate in the body. Instead, the carrier should have satisfactory ...
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MUTUAL PRODRUGS A SWOT ANALYSIS
... Mutual prodrug is a form of prodrug in which two pharmacologically active agents are attached to each other in such a way that each drug acts as a promoiety/carrier for each other and vice ...The ...
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Promoieties Used In Prodrug Design: A Review
... the prodrug design has found a number of compounds in clinical ...of mutual prodrug, promoeity may even add to therapeutic ...of prodrug examples published in literature indicate that newer ...
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SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF MUTUAL AMIDE PRODRUG OF SALICYLIC ACID AND ISONIAZID
... A mutual prodrug is a form of drug where two pharmacologically active agents are attached to each other in such a way that acts as a promoiety/ carrier for each ...partasa prodrug in salicylic acid ...
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Performance of Mutual Funds and Mutual Fund Manager in Pakistan
... considered mutual funds as the greatest tool for mobilizing savings and investments in any ...the mutual funds to healthier ...income mutual funds can be said ...secondary mutual fund ...
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A Survey: Static and Dynamic Ranking
... called mutual information. Mutual information helps to understand the relevance of results to the user query ...[7]. Mutual information is calculated by exploring the relationship between joint ...
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Small medium enterprises (SME) readiness to participate in workforce skills development
... The overall results showed that the employees readiness factors towards participation in skills development have high central of tendency, Mean between 3.89 – 4.12. This finding indicated that all these factors have the ...
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Synthesis and Characterization of Novel Sulphoxide Prodrug of Famotidine
... The partition coefficient of product was determined in n-octanol/water system (10:10) by standard technique. Product (drug or prodrug) was accurately weighed (10 mg) and added to 10 ml each of n-octanol and ...
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ESTER PRODRUG OF PARACETAMOL: SYNTHESIS, CHARACTERIZATION AND EVALUATION
... Hepatotoxicity: Paracetamol is a potent hepatotoxic agent. Standard group received paracetamol at a dose of 2000 mg/kg or 2 gm/kg, which is reported to produce hepatic tissue injury. Test group received 2.94 gm/kg of ...
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Structure-based design of anticancer prodrug PABA/NO
... Abstract: Glutathione S-transferase (GST) is a superfamily of detoxifi cation enzymes, represented by GST α , GST µ , GST π , etc. GST α is the predominant isoform of GST in human liver, playing important roles for our ...
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Stimuli responsive prodrug chemistries for drug delivery
... This review has aimed to cover some of the leading examples of pro-drug chemistries used to endow polymers with controlled and site-specific drug delivery properties. The heterogeneous nature of pathogenic sites with ...
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