MYCN amplification
Exon array analysis reveals neuroblastoma tumors have distinct alternative splicing patterns according to stage and MYCN amplification status
... [10]. MYCN is the most important biologic marker for neuro- ...disease. MYCN-amplified tumor is highly aggressive with poor outcome ...normal MYCN copy number (1-), stage 4 with MYCN ...
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Chromosome band 11q23 deletion predicts poor prognosis in bone marrow metastatic neuroblastoma patients without MYCN amplification
... gene is forkhead box R1 (FOXR1), which is located in 11q23.3. 11q23.3 deletion results in either mixed-line- age leukemia (MLL) or platelet activating factor acetyl- hydrolase 1b catalytic subunit 2 (PAFAH1B2) fusing to ...
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MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma
... in MYCN-amplified neuroblastoma, Gene Set Enrichment Analysis [19] was performed on pre- existing microarray data from a cohort of tumors from 650 neuroblastoma patients ...with MYCN amplification ...
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MYCN amplification predicts poor prognosis based on interphase fluorescence in situ hybridization analysis of bone marrow cells in bone marrow metastases of neuroblastoma
... of MYCN gene expression may not be possible due to the lack of availability of primary ...of MYCN gene of primary tumors maybe inaccurate after toxic chemotherapy, leading to insufficient dosage and period ...
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Protein arginine methyltransferase 5 is a key regulator of the MYCN oncoprotein in neuroblastoma cells
... gnomonic MYCN gene amplification and MYCN ...with MYCN gene amplification leads to greatly impaired growth and ...the MYCN-negative SH-SY5Y NB cell-line, or in two immortalized ...
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On the significance of germline cytogenetic rearrangements at MYCN locus in neuroblastoma
... of MYCN gain in NB remains ...of MYCN gene copies, eventually classified as MYCN gain, and the natural history of other NB patients with constitutional 2p duplication were the two rationales for ...
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Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma
... synthetic lethality screen using a druggable genome siRNA panel that contained 13904 siRNAs to target 6877 genes (Figure 1A, Supplementary table S1). We selected four cell lines from two major genetic subgroups based on ...
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Results of neuroblastoma treatment in Lithuania: a single centre experience
... the MYCN test and, therefore, it is possible that some of the patients with a localised form had the MYCN amplification and should have been in- cluded in the high-risk ...
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MYCN and PRC1 cooperatively repress docosahexaenoic acid synthesis in neuroblastoma via ELOVL2
... of MYCN slightly down- regulated SLC27A2 and FADS2 in IMR32 cells and did not affect the expression of ELOVL4, ELOVL5, SLC27A3 or FADS1 ...after MYCN depletion, the protein level of ELOVL2 was also ...
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... several MYCN-activated miRNAs, including miR- 181a-5p, miR-181b-5p, and ...and MYCN amplification generally co- occurs in NB patients [4], this reveals the importance of CAMTA1 in ...of MYCN ...
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The long non-coding RNA MYCNOS-01 regulates MYCN protein levels and affects growth of MYCN-amplified rhabdomyosarcoma and neuroblastoma cells.
... between MYCN and MYCNOS-01 transcript levels was then investigated by mining publically available expression profiling data for RMS and NB samples from patients and cell ...and MYCN expression and MYCNOS-02 ...
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A combined gene expression and functional study reveals the crosstalk between N-Myc and differentiation-inducing microRNAs in neuroblastoma cells
... MYCN amplification is the most common genetic alteration in neuroblastoma and plays a critical role in neuroblastoma ...tumorigenesis. MYCN regulates neuroblastoma cell differentiation, which is one ...
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Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma
... functional MYCN-157 signature that characterizes neuroblastoma tumors with MYCN amplification, as well as tumors with high MYCN protein levels without MYCN ...to MYCN, we ...
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A mouse model of MYCN driven retinoblastoma reveals MYCN independent tumor reemergence
... that MYCN acts as a potent oncogene in Rb-deficient ...and MYCN amplification are the two most frequent focal alterations occurring in human retinoblasto- ma, and these alterations often co-occur in ...
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MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma
... This study identified CD9 as a critical and indirectly druggable node in the neuroblastoma invasion-metastasis cascade. This is of particular interest since widespread and extensive metastatic burden causes most ...
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The emerging molecular pathogenesis of neuroblastoma: implications for improved risk assessment and targeted therapy
... Whole-genome analysis techniques such as comparative genomic hybridization (CGH) or array CGH enable the study of DNA copy number gains and losses over the entire genome in one single experiment [67] and have, since ...
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Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma
... that MYCN-amplified cell lines are more sensitive to harmine than NB cell lines with two MYCN gene ...and MYCN tumor amplification in human NB ...with MYCN gene amplification ...
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Exploiting the chick embryonic environment to reprogram neuroblastoma cells to a benign phenotype
... of MYCN, as cells of the SHEP cell line forced to overexpress both MYCN and Bmi-1 were highly resistant to a variety of apoptosis-inducing agents, compared to cells with high MYCN expression alone, ...
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Copy number gain of MYCN gene is a recurrent genetic aberration and favorable prognostic factor in Chinese pediatric neuroblastoma patients
... MYCN amplification is an established marker indicat- ing aggressive tumor progression of NBL ...that MYCN amplification is correlated with decreased overall survival in NBL ...of MYCN ...
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Prognostic value of ferritin, neuron-specific enolase, lactate dehydrogenase, and urinary and plasmatic catecholamine metabolites in children with neuroblastoma
... age, MYCN status, and ...without MYCN amplification the significant positive associations between urinary and plasmatic vanillylmandelic acid (VMA)/ homovanillic acid (HVA) ratio and a better ...
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