Mycobacterial disease
Evidence of mycobacterial disease in COPD patients with lung volume reduction surgery; the importance of histological assessment of specimens: A cohort study
... Fourteen histological reports had evidence of mycobac- terial infection, with one or more necrotising granulomas, and 8 of which showed acid-fast bacilli on Ziehl-Nielsen staining. As there was no clinical suspicion of ...
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Inherited Disorders of the Interleukin-12-Interferon Gamma Axis: Mendelian Predisposition to Mycobacterial Disease in Man
... Complete IL-12 p40 subunit deficiency leading to MSMD and Salmonella infections has also been described. The first case was born to consanguineous Pakistani parents and was immunised with BCG at birth (40). Sequencing ...
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Acquired predisposition to mycobacterial disease due to autoantibodies to IFN γ
... Genetic defects in the IFN-γ response pathway cause unique susceptibility to intracellular pathogens, particu- larly mycobacteria, but are rare and do not explain mycobacterial disease in the majority of ...
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Multiplex PCR assay for immediate identification of the infecting species in patients with mycobacterial disease
... and mycobacterial dis- ease caused by nontuberculous ...one mycobacterial species in immunosuppressed patients are increasingly being ...of mycobacterial disease relies primarily on the ...
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Susceptibility to mycobacterial disease due to mutations in IL-12R beta 1 in three Iranian patients
... Abstract In the last decade, autosomal recessive interleukin- 12 receptor β 1 (IL-12R β 1) deficiency, the most common cause of Mendelian susceptibility to mycobacterial disease (MSMD), has been diagnosed ...
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Clinical Analysis of Pulmonary Nontuberculous Mycobacterial Disease Diagnosed as Coincidental Pulmonary Infection Due to Mycobacterium Species*
... pulmonary mycobacterial disease diagnosed as coincidental pulmonary infection due to Mycobacterium ...nontuberculous mycobacterial disease proposed by American Thoracic Society during the last ...
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Latent class analysis to define radiological subgroups in pulmonary nontuberculous mycobacterial disease
... The principle limitation of the study is the heteroge- neous nature of the cohort, comprising subjects with dif- fering underlying respiratory diseases, NTM species, antibiotic treatments and infecting co-pathogens. ...
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Defining dormancy in mycobacterial disease
... Through in vitro dormancy models a range of susceptibility test are used (MIC, MBC and percentage of cell surviving after different exposure time using CFU or resazurin reduction). This results in different drug dose for ...
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Buruli Ulcer: Review of a Neglected Skin Mycobacterial Disease
... BU is a neglected skin infectious disease caused by M. ulcerans that has been found in at least 33 countries in tropical and subtropical regions in Africa, the Americas, and Western Pacific regions. The infection ...
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PCR assay based on DNA coding for 16S rRNA for detection and identification of mycobacteria in clinical samples
... 108 mycobacterial strains (33 species) and 31 nonmycobacterial strains (of 17 ...the mycobacterial strains from which the cross-hybridizing PCR products were derived belonged to nonpathogenic or ...
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Blurring the Lines in Interferon γ Receptor Deficiency: An Infant With Near-Fatal Airway Disease
... bronchial disease after a 4-month history of rhinorrhea, wheeze, and acute lobar ...between mycobacterial disease and IFN- ␥ path- way deficiency, the diagnosis of which facilitates more accurate ...
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Phenotypic, immunologic, and clinical characteristics of patients with nontuberculous mycobacterial lung disease in Korea
... MR, Chernick M, Steagall WK, Glasgow CG, Lin J, Jolley C, Sorbara L, Raffeld M, Hill S, Avila N, Sachdev V, Barnhart LA, Anderson VL, Claypool R, Hilligoss DM, Garofalo M, Fitzgerald A, Anaya-O'Brien S, Darnell D, ...
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MicroRNA 889 Inhibits Autophagy To Maintain Mycobacterial Survival in Patients with Latent Tuberculosis Infection by Targeting TWEAK
... Increasing evidence reveals that TNF- ␣ inhibitors are associated with an elevated risk of LTBI reactivation (39, 40). Since TNF- ␣ is involved in granuloma maintenance, neutralizing TNF- ␣ tends to disrupt the granuloma ...
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Immunoglobulin A (IgA) and IgG serum antibodies to mycobacterial antigens in Crohn's disease patients and their relatives
... paratuberculosis whole-cell antigen, using a mixture of anti-human IgA, IgE, IgG, and IgM as second antibody, and found significantly higher reactions with sera from patients with Crohn'[r] ...
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Mycobacterium avium complex disease in patients with AIDS: seroreactivity to native and recombinant mycobacterial antigens
... Antibodies to Mycobacterium avium complex MAC antigens were measured by enzyme-linked immunosorbent assays and immunoblot analyses in sera from 20 patients with AIDS and disseminated MAC[r] ...
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Characteristics associated with progression in patients with of nontuberculous mycobacterial lung disease : a prospective cohort study
... lung disease required treatment eventually [5, ...experience disease progression, an obser- vation period is usually needed to decide whether or not to initiate treatment [7, ...lung disease, the ...
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Mycobacterial RNA Polymerase Requires a U Tract at Intrinsic Terminators and Is Aided by NusG at Suboptimal Terminators
... including mycobacterial genomes (14, 16–18), mak- ing reports that mycobacterial RNAP is susceptible to an alternative intrinsic termination mechanism of considerable in- terest (16, 18, ...recombinant ...
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Imbalanced effector and regulatory cytokine responses may underlie mycobacterial immune restoration disease
... restoration disease (IRD) is an adverse consequence of antiretroviral therapy, where the restored pathogen-specific response causes ...and mycobacterial IRD is a common cause of morbidity in HIV-infected ...
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The influence of environmental exposure on the response to antimicrobial treatment in pulmonary Mycobacterial avium complex disease
... ATS Mycobacterial Diseases Subcommittee; American Thoracic Society; Infectious Disease Society of America: An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous ...
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Mycobacterial OtsA Structures Unveil Substrate Preference Mechanism and Allosteric Regulation by 2 Oxoglutarate and 2 Phosphoglycerate
... Trehalose, an essential disaccharide in mycobacteria, is one of the critical compo- nents of the cell wall. The OtsA-B pathway is an essential source of trehalose for these organisms, with knockouts of this pathway being ...
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