Myocardial hypertrophy
Original Article SNF5 alleviates Ang II-induced myocardial hypertrophy by inactivation of MAPK/mTOR pathway
... MAPK and mTOR signaling pathways play piv- otal roles in mediation of multiple biological processes, including cell proliferation, cell cycle and apoptosis [23-27]. To date, the exact signal transduction mechanism of ...
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Original Article The attenuation of myocardial hypertrophy by atorvastatin via the intracellular calcium signal and the p38 MAPK pathway
... Cardiac hypertrophy, which is associated with myocardial fibrosis, capillary rarefaction, in- flammatory reaction, and cellular dysfunction, which can consequently cause maladaptive ventricular remodeling ...
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Original Article MicroRNA-96 promotes myocardial hypertrophy by targeting mTOR
... MiRs are very small non-coding post transcrip- tion regulating RNAs, and have been shown to exert a critical role in regulating mRNA in heart diseases and cell apoptosis [4]. Growing evi- dences regarding microRNA ...
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DUCTUS VENOSUS FLOW, DIASTOLIC DYSFUNCTION AND MYOCARDIAL HYPERTROPHY IN FETUSES OF DIABETIC MOTHERS
... ratio. Myocardial hypertrophy was characterized by a ventricular septum thickness at the end of diastole greater than 2 standard deviations for gestational age according to Allan ...
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Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice
... endothelial-driven myocardial hypertrophy affected cardiac performance, we performed echocardiographic and pressure-volume loop analyses of myocardial ...of myocardial dilatation, there was a ...
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Prevalence of myocardial hypertrophy in a population of asymptomatic Swedish Maine coon cats
... Our study has a number of limitations. The number of cats and breeders is too small to estimate the prevalence of HCM in the whole population of Swedish Maine coon cats, and reference values for Maine coon cats in ...
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CaMKII and a failing strategy for growth in heart
... cardial hypertrophy is an early event in most forms of heart failure, but the majority of patients with myocardial hypertrophy do not develop heart ...early myocardial insult to heart failure ...
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Effects of traditional Chinese medicine Xin Ji Er Kang formula on 2K1C hypertensive rats: role of oxidative stress and endothelial dysfunction
... The myocardial hypertrophy index was expressed as heart weight/body weight (HW/BW), the histological changes were investigated by hematoxylin and eosin (HE) and Van Gieson (VG) ...
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Original Article Expression of CX43 and SOCS-1 in patients with sudden cardiac death
... and myocardial hypertrophy may further contribute to ...to myocardial hypertrophy via the JAK/STAT signaling path- way and MAPK signaling ...
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Multikinase inhibitor sorafenib prevents pressure overload-induced left ventricular hypertrophy in rats by blocking the c-Raf/ERK1/2 signaling pathway
... cardiac hypertrophy is one of de- velopmental organ anomalies suggesting an important role of c-Raf in pathophysiological modulation of cardiac hypertrophy ...of myocardial hypertrophy in ...
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Histopathological Spectrum of Heart Diseases in Autopsy Specimens
... of myocardial infarction was present in 14 (6%) ...reported myocardial infarction in 48% cases which is higher than this study ...al myocardial infarction was observed in ...was myocardial ...
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Effect of age on myocardial adaptation to volume overload in the rat
... myocardial hypertrophy in response to aortic insufficiency in young adult (9 mo) and old (18 or 22 mo) Fischer rats. Before, immediately after, and at 2 and 4 wk after creating aortic insufficiency, LV and ...
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NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth
... Myocardial hypertrophy is an adaptation to increased hemodynamic ...of myocardial angiogenesis pro- motes cardiomyocyte growth and cardiac hypertrophy through a novel NO-dependent ...late ...
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Differential diagnosis of thickened myocardium: an illustrative MRI review
... When myocardial hypertrophy is ≥15 mm or is asymmet- ric, distinguishing hypertensive heart disease from HCM can be difficult ...septal hypertrophy can be seen in up to 10% of cardiac patients ...
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Effects of exerimental right ventricular hypertrophy on myocardial blood flow in conscious dogs
... myocardial blood flow in the absence of an elevated coronary arterial driving pressure were evaluated in 18 concscious dogs subjected to a chronic pressure overload of the right ventricle induced by pulmonary ...
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Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice
... The adult heart responds to sustained pressure overload by devel- oping ventricular hypertrophy. The signaling events mediating this process are substantially driven by activation of GPCRs, which in turn stimulate ...
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Cardiogenic shock accompanied by dynamic left ventricular outflow tract obstruction and myocardial bridging after transient complete atrioventricular block mimicking ST elevation myocardial infarction: a case report
... Case presentation: A 65-year-old man with hypertension presented himself at the emergency department with syncope after chest pain. His initial electrocardiography showed inferior ST elevation with profound precordial ST ...
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In utero and early life exposure to diesel exhaust air pollution increases adult susceptibility to heart failure in mice
... As both acute and chronic exposure to DE has been suggested to incite a pulmonary cytokine response, we measured the relative mRNA content of the proinflam- matory cytokines interleukin 6 (IL6) and tumor necrosis factor ...
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Caffeic acid ethanolamide prevents cardiac dysfunction through sirtuin dependent cardiac bioenergetics preservation
... ventricular hypertrophy, myocardial fibrosis, elevated lipid peroxidation, cardiac adenosine triphosphate and left ventricular ejection fraction decline, suggesting oxidative stress and bioenergetics ...
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Pivotal role of cardiomyocyte TGF β signaling in the murine pathological response to sustained pressure overload
... The cardiac pathological response to sustained pressure overload involves myocyte hypertrophy and dysfunction along with interstitial changes such as fibrosis and reduced capillary density. These changes are ...
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