myosin binding
Cardiac Myosin Binding Protein C: At the Heart of Hypertrophic Cardiomyopathy in Humans and Domestic Cats
... Hypertrophic cardiomyopathy (HCM) is a disease of the myocardium that is estimated to affect one in 500 individuals (Marian & Roberts, 2001; Maron, 2002). Additionally, it is the most common form of cardiovascular ...
7
Dilated cardiomyopathy in homozygous myosin binding protein C mutant mice
... cardiac myosin-binding protein-C (MyBP-C) in myocardial structure and func- tion, we have produced mice expressing altered forms of this sarcomere ...cardiac myosin heavy chain-binding and ...
11
Novel splice donor site mutation in the cardiac myosin binding protein C gene in familial hypertrophic cardiomyopathy Characterization Of cardiac transcript and protein
... Recent findings defined cardiac MyBP-C mutations as a possi- ble cause of FHC. Based on altered lymphocyte cDNA se- quence, the mutations described so far are predicted to pro- duce a truncated cardiac MyBP-C with ...
9
The Mechanisms of the Frank-Starling Law and Familial Cardiomyopathy are Different. The Function of Myosin Binding Protein-C is Retained on Myocyte Length Increase and Force Generated is Kinase controlled
... the myosin-bound ATP or the myosin bound products MgADP and Pi or transient ...The Myosin binding Protein-C (MyBP-C) makes Ca 2+ -Mg 2+ exchange or a consequent step rate-limiting in ...
8
HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C
... cardiac myosin binding protein C (MYB- PC3), accounting for more than 50% of cases in which the causative gene has been identified ...both myosin and actin, acting as a molecular brake on ...
17
A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy
... the myosin binding site but containing most of the titin binding site is expressed, as this protein might insert more efficiently, yet still incorrectly into the ...
10
Research Progress of Cardiac Myosin Binding Protein C in Dilated Cardiomyopathy and Other Cardiac Conditions
... Since its discovery, myosin-binding protein C (cMyBP-C) has become a pro- tein of interest clinically. With emergence of new methodologies and tech- nologies, the structure and functions of cMyBP-C from ...
10
Calcium, Actomyosin Kinetics, Myosin Binding Protein-C and Hypertrophic Cardiomyopathy
... of myosin binding protein-C is to ensure that MgATP is not the apparent substrate for cross-bridge cycling in the unperturbed normal heart and the Ca 2+ -Mg 2+ exchange defines the rate limiting step of the ...
5
Genetic mutations and mechanisms in dilated cardiomyopathy
... components myosin heavy chain and myosin binding protein C (MYH7 and MYBPC3) together explain 75% of inherited HCMs, leading to the observation that HCM is a disease of the ...
9
Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β cardiac myosin
... -cardiac myosin, the motor protein that powers ventricular ...non-cardiac myosin, there is no clear consensus about the mechanism of action of these mutations on the function of human β -cardiac ...-cardiac ...
7
Unphosphorylated twitchin forms a complex with actin and myosin that may contribute to tension maintenance in catch
... (with myosin and/or ...the myosin-binding sites on the D2 peptide are not ...direct binding to the D2 site (S4316) is involved, but this could occur for one of the ...titin, myosin ...
12
Temperature plasticity of contractile proteins in fish muscle
... domain. Myosin is organized in situ into thick filaments in which the heads of the myosin molecules protrude from the surface of the thick filament and form cross- bridges with actin-containing thin ...two ...
6
Transcriptional Enhancer Activity of Biochemically Marked Genomic Elements
... TF binding sites thus acts as a regulatory gate to transcriptional regulatory functions, including fine tuning by the combinations of off-DNA cofactors which are able to recruit other complexes and by the ...
268
A Point Mutation in the Cargo-Binding Domain of Myosin V Affects Its Interaction with Multiple Cargoes
... Vac17p binding site has been mapped to subdomain ...the binding site for Smy1p had been proposed to map to the C terminus (subdomain II) ...receptor binding site ...
12
Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice
... Immunization experiments in BALB/c mice with fragments of rat cardiac myosin suggested that pathogenic epitopes re- side between aa 736 and 1032 (17). According to amino acid sequence comparison, this particular ...
7
Myosin-X and myosin-XIX in intracellular transport
... as
its
light
chain in
vitro (Homma
et
al.,
2001;
Homma
and
Ikebe,
2005;
Kovacs
et
al., 2005). Additionally,
Myo10
can
bind
to
calmodulin‐like
protein
(CLP),
an
epithelial‐. specific
[r] ...
158
Myosin VI and its binding partner optineurin are involved in secretory vesicle fusion at the plasma membrane.
... of myosin VI suggests a role for this protein in the early stages of ...). Myosin VI proteins moving along such ERES-associated actin fi la- ments could play a role in mediating COPII exit from the ER, ...
12
Leading-process actomyosin coordinates organelle positioning and adhesion receptor dynamics in radially migrating cerebellar granule neurons
... As myosin ii motor activity and F-actin dynamics in the leading process are crucial for centrosomal two-stroke motility, we next used the fluorescence-labeled utrophin actin-binding domain (UTRCH-ABD) and ...
19
The role of palladin in actin organization : implications for the glial scar
... F-actin binding in palladin’s relatives myotilin and kettin (von Nandelstadh et ...for binding to filamentous ...actin binding. The Ig4 and Ig5 domains showed no actin-binding activity, ...
178
Biochemical basis of the muscular activity of erlangia cordifolia (S Moore) (Gathuna)
... the myosin polymer would become dissipated along the length of the ...the myosin polymer leave the Optical Rotary Dispersion Spectrum essentially the same as it was before the hydrolysis of the ...of ...
192