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N Acetyl 3,5 di­bromo L tyrosine hemihydrate

N Acetyl 3,5 di­bromo L tyrosine hemihydrate

starting material. A short intermolecular Br Br separation is observed [3.2938 (3) A ˚ ]. The molecules in the crystal are connected via a network of hydrogen bonds through an N— H O hydrogen bond between the hydroxy group of the phenol of the tyrosine and the N—H of the amide of the other molecule and an O—H O hydrogen bond between the hydroxy group of the carboxylic acid and the oxygen of the carbonyl of the amide.

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Bis(μ N acetyl N phenyl­glycinato κ2O:O′)­bis­­[tri­aqua(1,10 phenanthroline κ2N,N′)­lanthanum(III)] bis­(N acetyl N phenyl­glycinate) dinitrate dihydrate

Bis(μ N acetyl N phenyl­glycinato κ2O:O′)­bis­­[tri­aqua(1,10 phenanthroline κ2N,N′)­lanthanum(III)] bis­(N acetyl N phenyl­glycinate) dinitrate dihydrate

The LaÐO bond lengths in (I) are in the range 2.415 (2)± 2.553 (2) AÊ, with a carboxylate O atom making the shortest bond. The average LaÐN bond length in (I) of 2.766 AÊ is longer than that seen (2.666 AÊ) in bis[tris(N-phenyl-N- acetylglycine)(1,10-phenanthroline)lanthanum] (Fu et al., 2004)

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N Acetyl 2 hy­droxy N′ [meth­oxy(1 methylindol 2 yl)methyl]benzohydrazide

N Acetyl 2 hy­droxy N′ [meth­oxy(1 methylindol 2 yl)methyl]benzohydrazide

Szczepankiewicz, B. G., Liu, G., Jae, H.-S., Tasker, A. S., Gunawardana, I. W., von Geldern, T. W., Gwaltney, S. L., Wu-Wong, R., Gehrke, L., Chiou, W. J., Credo, R. B., Alder, J. D., Nukkala, M. A., Zielinski, N. A., Jarvis, K., Mollison, K. W., Frost, D. J., Bauch, J. L., Hui, Y. H., Claiborne, A. K., Li, Q. & Rosenberg, S. H. (2001). J. Med. Chem. 44, 4416–4430.

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Crystal structure of N {N [N acetyl (S) leuc­yl] (S) leuc­yl}norleucinal (ALLN), an inhibitor of proteasome

Crystal structure of N {N [N acetyl (S) leuc­yl] (S) leuc­yl}norleucinal (ALLN), an inhibitor of proteasome

Data collection: sergui, SER-CAT APS beamline software; cell refinement: HKL-2000 (Otwinowski & Minor, 1997); data reduction: HKL-2000 (Otwinowski & Minor, 1997); program(s) used to solve structure: SHELXD (Sheldrick, 2008); program(s) used to refine structure: SHELXL (Sheldrick, 2008); molecular graphics: ORTEP-3 for Windwows (Farrugia, 2012) and pyMOL (DeLano, 2002); software used to prepare material for publication: SHELXL97 (Sheldrick, 2008). N-{N-[N-Acetyl-(S)-leucyl]-(S)-leucyl}norleucinal

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N Acetyl N [1 (2 naphthalenyl)­ethenyl]­acet­amide

N Acetyl N [1 (2 naphthalenyl)­ethenyl]­acet­amide

The title compound, N-acetyl-N-[1-(2-naphthalenyl)ethenyl]- acetamide, (I), was obtained as a by-product when we synthesized N-[1-(2-naphthalenyl)ethenyl]acetamide (Burk et al., 1998). In (I), the dihedral angle between the planar naphthalene moiety and the plane consisting of N1, O1, O2, C13±C16 is 82.76 (5) . The crystal structure is stabilized by

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4 N Acetyl­amino 5 [N acetyl N (tetra O acetyl β D gluco­pyranos­yl)amino] 1,3 di­methyl­uracil

4 N Acetyl­amino 5 [N acetyl N (tetra O acetyl β D gluco­pyranos­yl)amino] 1,3 di­methyl­uracil

X-ray data were collected at the EPSRC X-ray Crystal- lographic Service, University of Southampton, England. The authors thank the staff for all their help and advice. ASR, MNM and JC thank the Consejerı´a de Innovacio´n, Ciencia y Empresa (Junta de Andalucı´a, Spain) and the Universidad de Jae´n for financial support.

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Tetra­kis­(μ N acetyl N phenyl­glycinato κ2O,O′)­bis­­[(N acetyl N phenyl­glycinato κ3O,O,O)(1,10 phenanthroline κ2N,N′)­cerium(III)] dihydrate

Tetra­kis­(μ N acetyl N phenyl­glycinato κ2O,O′)­bis­­[(N acetyl N phenyl­glycinato κ3O,O,O)(1,10 phenanthroline κ2N,N′)­cerium(III)] dihydrate

each Ce atom shows a distorted tricapped trigonal prismatic coordination, comprising two N-atom donors from a 1,10- phenanthroline ligand and seven O atoms of the N-acetyl-N- phenylglycine (L2) molecules. Two Ce atoms are bridged by two terdentate and two bidentate carboxylate groups of L2, to give a centrosymmetric dimer. The crystal structure is stabilized by intermolecular OÐH O hydrogen bonds.

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N acetyl endorphin in rat spermatogonia and primary spermatocytes

N acetyl endorphin in rat spermatogonia and primary spermatocytes

confirmed these previous reports and extended them by showing that the majority of testicular endorphins are acetylated forms, N-acetyl gamma-endorphin, N-acetyl alpha- endorphin, and N-acetyl beta-endorphin1-27. In addition, N-acetylated endorphins are not found in interstitial cells, but are confined to spermatogonia and primary spermatocytes.

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Tetra­kis­(μ N acetyl N phenyl­glycinato)­bis­­[(N acetyl N phenyl­glycinato)(1,10 phenanthroline κ2N,N′)­lanthanum(III)] dihydrate

Tetra­kis­(μ N acetyl N phenyl­glycinato)­bis­­[(N acetyl N phenyl­glycinato)(1,10 phenanthroline κ2N,N′)­lanthanum(III)] dihydrate

The mixture was stirred for 4 h and about half of the solvent was evaporated in a rotary vacuum evaporator at the same temperature. The resulting solution was ®ltered and left to stand in air for about 20 d. Large yellow block-shaped crystals of (I) were obtained (m.p. 531.5 K). Elemental analysis found: C 55.13, H 4.32, N 7.52%; calculated for C 84 H 80 La 2 N 10 O 20 : C 55.21, H 4.41, N 7.66%.

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N Acetyl L alanine

N Acetyl L alanine

Ponnuswamy, M. N. & Trotter, J. (1985). Acta Cryst. C41, 917±919. Regulla, D. F. & Deffner, U. (1982). Appl. Radiat. Isot. 33, 1101±1114. Sheldrick, G. M. (1996). SADABS. University of GoÈttingen, Germany. Stout, K. L., Hallock, K. J., Kampf, J. W. & Ramamoorthy, A. (2000). Acta

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N Acetyl L valine

N Acetyl L valine

N-Acetyl-l-valine, (I), is a versatile synthon in the synthesis of several pharmaceuticals and their key intermediates (Reddy et al., 1999; Heavner, 1997). In a continuation of our work on the structure±activity relationship of the avermectin B1 deriva- tives, we have obtained a colourless crystalline compound that was the product of acetylation of l-valine. The structural identity of our product, (I), was resolved using single-crystal X-ray diffraction to determine the molecular structure.

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N ACETYL CYSTEINE ALLEVIATES PHENYTOIN INDUCED BEHAVIORAL ABNORMALITIES IN RATS

N ACETYL CYSTEINE ALLEVIATES PHENYTOIN INDUCED BEHAVIORAL ABNORMALITIES IN RATS

Our work is a preliminary and pioneering study to assess the ameliorative effect of NAC against phenytoin induced behavioral abnormalities. Phenytoin and its metabolites are reported to induce oxidative stress in brain regions via free radical generation leading to behavioral abnormalities. Thus it is worthwhile to explore the protective effect of NAC against phenytoin induced behavioral abnormalities. The influence of NAC against phenytoin impaired memory; exploratory behavior, spontaneous motor activity and locomotor activity were studied along with estimation of regional brain lipid peroxidation and acetyl cholinesterase (ACh E) activity. Our hypothesis proposes that antioxidant property of NAC offers protection against phenytoin induced behavioral abnormalities. Antioxidant supplementation is suggested to render an excellent antiepileptic therapy devoid of toxicity which may improve the quality of life in patients under phenytoin treatment.

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N Acetyl DL phenyl­glycine

N Acetyl DL phenyl­glycine

The crystal packing projected on to the ac face is shown in Fig. 2. The layered structure is composed of columns that are two molecules wide, with the phenyl groups facing the interior of the columns and the acetylglycine substituents forming the sides of the columns. O—H O and N—H O hydrogen bonds (Table 1) link the molecules along the outer edges of the columns. There is also a short C—H O contact [C16 O3 = 3.43 (4) A ˚ ] across the center of the columns.

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N Amino N (2,3,4 tri O acetyl β D xylo­pyran­osyl)­thio­carb­amide

N Amino N (2,3,4 tri O acetyl β D xylo­pyran­osyl)­thio­carb­amide

Atoms H3A and H3B were located in a difference map and included in the re®nement with an NÐH distance restraint of 0.89 (1) AÊ. The remaining H atoms were positioned geometrically (NÐH = 0.86 AÊ and CÐH = 0.96±0.98 AÊ) and treated as riding, with U iso (H) = 1.2U eq (C,N) [for methyl H atoms, U iso (H) = 1.5U eq (C)]. A

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Ethyl N (2 acetyl 3 oxo 1 phenyl­but­yl)carbamate

Ethyl N (2 acetyl 3 oxo 1 phenyl­but­yl)carbamate

In I (Fig. 1), all bond lengths and angles are normal and correspond well to those observed in the related (1R,2R)-benzyl (3-oxo-2-((2-oxo-1,3-oxazolidin-3-yl)carbonyl)-1-phenylbutyl)carbamate and (S)-benzyl (2-acetyl-1-(4-bromophenyl)-2- hydroxy-3-oxobutyl)carbamate (Hatano et al., 2008). In the molecule, all three carbonyl groups are syn oriented with respect to the methine group attached to the phenyl ring.

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Effect of N-Acetyl Cysteine on Liver Function in General Anesthesia with Isoflurane

Effect of N-Acetyl Cysteine on Liver Function in General Anesthesia with Isoflurane

Toxicity with volatile anesthesia usually takes place after their decomposition in the body and this molecular decomposition results in peroxidation of fats. N-acetylcysteine (NAC) is the acetylated compound of L-cysteine amino acid which can also act as the source of sulfhydryl groups. In our body, this material turns into metabolites which stimulate glutathione and result in detoxification and discharge of free radicals. Prescription of NAC as a mucolytics has been used since a long time ago. Seemingly, this medicine can be really effective in the cases when the level of GSH has decreased significantly or in the condition when the body faces a large accumulation of oxidative materials (HIV infections, cancer, cardiovascular disease, etc). NAC seems to have useful effects in absorption of heavy metals in the case of toxicities and protects the liver and kidney from their negative effects and improves their disposal. This medicine is mostly used to treat toxication with acetaminophen and those patients suffering from COPD, inflammatory diseases of the joints, ARDS, etc 6-9 .

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Endo-N-Acetyl-β-D-Glucosaminidases and Peptide-N4-(N-acetyl-β-D-Glucosaminyl) Asparagine Amidases: More Than Just Tools

Endo-N-Acetyl-β-D-Glucosaminidases and Peptide-N4-(N-acetyl-β-D-Glucosaminyl) Asparagine Amidases: More Than Just Tools

The fungal N-glycan-ENGase isolated from Mucor hiemalis, EndoM, displayed a specificity similar to Endo F but was shown able to hydrolyse biantennary complex-type N-glycans that Endo F cannot cleave and could even act on triantennary structures while Endo F could not [111,112]. However, Endo M is essentially known as a useful enzyme for the synthesis of neoglycopeptides due to its transglycosylation activity [133]. The EndoM gene encodes a putative 744 amino acid protein, which shows high identity to ENGases in the GH85 family [134]. The first yeast ENGase, from Ogataea minuta (Endo Om), was very recently reported [135]. Endo Om encoding gene was directly amplified from O. minuta genomic DNA and sequenced. The deduced amino acid sequence indicated that the putative protein belonged to GH85 family. Homologous ENGase sequences were identified by database searches; in other yeast strains, Candida parapolymorpha, Pichia anomala and Zygosaccharomyces rouxii and corresponding enzyme activities were also confirmed in crude cell extracts from those strains. Neither ENGase sequence nor activity were present in S. cerevisiae and P. pastoris [135]. Endo Om exhibited substrate preference for high-mannose N-glycans, and was able to cleave hybrid, biantennary and (2,6)-branched triantennary N-glycans, but not tetraantennary, (2,4)-branched triantennary, bisecting GlcNAc containing and core-fucosylated biantennary N-glycans. Endo Om also was able to hydrolyze N-glycans attached to RNase B and human transferrin under both denaturing and non-denaturing conditions. It was proposed that Endo Om acts in vivo to trim the proximal GlcNAc1 residue (chitobiose activity) and/or to directly digest N-glycans on misfolded glycoproteins (ENGase activity).

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2 [N (4 Meth­­oxy­phen­yl)acetamido] 1,3 thia­zol 4 yl acetate

2 [N (4 Meth­­oxy­phen­yl)acetamido] 1,3 thia­zol 4 yl acetate

thiazole ring, may indicate that one of the starting materials, i.e. 2-(4-methoxyanilino)-1,3-thiazol-4(5H)-one, exists in the reaction mixture, at least partially, as a tautomer with an exocyclic amine N atom and an enol group. The acetoxy and acetyl groups deviate from the thiazole plane by 69.17 (6) and 7.25 (19) , respectively. The thiazole and benzene rings form a dihedral angle of 73.50 (4) . In the crystal, centrosymmetri- cally related molecules are connected into dimeric aggregates via C—H O interactions.

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4 Acetyl N,N di­benzoyl­phenyl­amine

4 Acetyl N,N di­benzoyl­phenyl­amine

In recent years, photo-induced electron transfer (PET) reac- tions of organic compounds have been extensively invest- igated (Scheinbaum, 1964; Kavarnos & Turro, 1986; D'Auria et al., 1996). Such PET reactions of nitroaromatic compounds, which are electron acceptors, with a variety of donors are also of interest. We have recently investigated the photo-induced reactions between nitroaromatic compounds and diphenyl- acetylenes, which give the corresponding benzenamines as one of the products. The crystal structure of N,N-dibenzoyl-4- chloroaniline, which resulted from such a reaction between 4-chloronitrobenzene and an excess amount of 1,2-diphenyl- acetylene, has been reported (Usman et al., 2002). We carried out a similar reaction for 4-carbomethoxynitrobenzene and isolated the title compound, (I), which was structurally analysed in order to elucidate its conformation.

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Effect of N  Acetyl Cysteine on Wound Healing

Effect of N Acetyl Cysteine on Wound Healing

N- acetyl cysteine was evaluated for its wound healing activity in ether anaesthetized albino rats by using incision, excision wound models. Significant increase in skin breaking strength, granuloma breaking strength, wound contraction and decreased in epithelization period was observed. A supportive study made on granuloma tissue to estimate the levels of superoxide-dismutase, catalase, glutathione, vitamin c and lipid peroxidation are recorded and a significant increase in the level of these antioxidant enzymes and decrease in the levels of lipid peroxidation was observed. Enhanced wound healing activity may be due to free radical scavenging action of the NAC and the enhanced level of antioxidant enzymes in granuloma tissue. Better collagenation may be because of improved antioxidant studies.

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