N-end rule
Studies of the N-end Rule Pathway in Bacteria and Mammals
... The N-end rule pathway, the first specific pathway of UPS to be discovered, relates the in vivo half-life of a protein to the identity of its N-terminal ...the N-end rule ...
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Enhanced waterlogging tolerance in barley by manipulation of expression of the N end rule pathway E3 ligase PROTEOLYSIS6
... the N-end rule pathway of targeted proteolysis through the Nt-Cys that is exposed following the action of MAPs (Figure 1a) (Gibbs et ...the N-end rule pathway using an in vitro ...
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The Cys Arg/N end rule pathway is a general sensor of abiotic stress in flowering plants
... The five Arabidopsis ERFVII AP2-domain transcription factors (RELATED TO APETALA(RAP)2.12, RAP2.2, RAP2.3, HYPOXIA RESPONSIVE ERF (HRE)1, HRE2) are the only known physiological substrates of the ...
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Quantitative proteomics analysis of the Arg/N-end rule pathway of targeted degradation in Arabidopsis roots
... tein N-termini ...in N-end rule mutants, indicating that proteins initiating with destabilising residues are not necessarily targeted for ...prokaryotic-like N-end rule ...
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Development of N-end Rule Ubiquitin Pathway Inhibitors and Hsp-90 Targeted miRNA Delivery System As Novel Anticancer Therapeutics
... stabilizing N-terminal residues ...basic N-terminal residues ...hydrophobic N-terminal residues (e.g. Phe, Leu, Ile) are type 2 substrates of the N-end rule ...by ...
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“The N-End Rule Pathway: Its Physiological Importance and Role in Disease Pathology” by Subrata Kumar Pore, Rajkumar Banerjee, India.
... In mammalian cells, full length XIAP degradation is also observed via N-end rule pathway. Du et al. showed that UBR1 bears a third substrate binding site which remains blocked by its C-terminal ...
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Genetic interactions between ABA signalling and the Arg/N-end rule pathway during Arabidopsis seedling establishment
... In this study, we examined further the relationship between ERFVIIs, ABA signalling and PRT6 action in Arabidopsis seedlings. ABI4 as well as ABI3 and ABI5 was found to contribute to ABA sensitivity of germination and ...
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Development of Novel Synthetic Bivalent Inhibitors of N-end Rule Ubiquitin Pathway and Sigma Receptor - targeted Anticancer Therapeutics
... of N-recognins reveals the presence of at least two spatially proximal binding sites: type 1 site binds to basic N-terminal residues ...hydrophobic N-terminal residues ...2 N-terminal residues ...
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The N end rule pathway promotes seed germination and establishment through removal of ABA sensitivity in Arabidopsis
... the N-end rule pathway in seed germination and ...the N-end rule pathway) have been shown to have a small influence on germination potential in the presence of ABA, or to ...
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Ubiquitin conjugation by the N end rule pathway and mRNAs for its components increase in muscles of diabetic rats
... Insulin deficiency (e.g., in acute diabetes or fasting) is associated with enhanced protein breakdown in skeletal muscle leading to muscle wasting. Because recent studies have suggested that this increased proteolysis is ...
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The Cys Arg/N end rule pathway is a general sensor of abiotic stress in flowering plants
... the N-end rule pathway regulates down- stream responses to enhance tolerance to ...addition, N-end rule and NR control of ERFVII stability and function influences the speed of ...
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Biochemical and Genetic Studies of the N-End Rule Pathway in Yeast and Mammals
... Arg/N-end rule pathway and one subject of the present study ...only N-terminal Asp and Glu but also N-terminal Cys, if it has been oxidized to Cys- sulfinate or Cys-sulfonate, through ...
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The N end rule and retroviral infection: no effect on integrase
... the N-end rule pathway we decided to examine the role of HIV-1 ...the N-end rule [18,20,21] and it has been a focus for the development of small molecule inhibitors in recent ...
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N terminomics reveals control of Arabidopsis seed storage proteins and proteases by the Arg/N end rule pathway
... by RT-qPCR. RD21A and SLP2 transcripts were less abundant in prt6-1 seedlings than Col-0; RD19A was unchanged and CP1 was more abundant in prt6-1, indicative of distinct modes of con- trol (Fig. 6). As it is generally ...
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Distinct branches of the N end rule pathway modulate the plant immune response
... NTAQ1 function influences defence gene expression and synthesis of camalexin.. demonstrate that downstream responses to NTAQ1, measured as responsive gene.[r] ...
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Studies of the N-End Rule Pathway in Saccharomyces cerevisiae
... Arg/N-‐end rule pathway and a part of the UFD pathway as ...Arg/N-‐end rule and UFD substrates, in comparison to targeting by Ubr1 or Ufd4 ...to N-‐terminal Ub but not ...
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Oxygen-dependent proteolysis regulates the stability of angiosperm polycomb repressive complex 2 subunit VERNALIZATION 2
... proteolysis and that the N-end rule pathway is involved in restricting the accumulation of VRN2 in the absence of cold temperatures. Prolonged growth in the cold led not only to VRN2 accumulation, ...
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Nitric oxide sensing in plants is mediated by proteolytic control of Group VII ERF transcription factors
... enhanced promABI5:GUS expression (Figure S5B), and expo- sure of dormant seeds to the NO donor SNP abolished promA- BI5::GUS activity in WT, but had no effect in prt6 (Figure 4C). Interestingly, GUS expression driven by ...
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Tandem fluorescent protein timers for non-invasive relative protein lifetime measurement in plants
... the N-end rule tFT reporters in root cells of 7 d-old wild-type plants and N-end rule E3-ligase-deficient mutants (prt1-1 and prt6-5) treated for 4 h with the proteasome ...
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Efficient 1024 Point Low Power Radix 22 FFT Processor with MFFMD
... = N/P At every stage„s‟, Distance end to end of the cushion in rearranging organization L = N/2^(s+1) Total example recall required = N–P Maximum recollection expected to carry out ...
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