N-Ras
Murine Leukemia Virus Proviral Insertions between the N-ras and unr Genes in B-Cell Lymphoma DNA Affect the Expression of N-ras Only
... increased N-ras expression, while the expression of unr was ...as N-ras, as did two previously reported cases of MLV insertions at this site in lymphomas (11, 26), and all five integrations ...
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Expression of c-Jun, p73, Casp9, and N-ras in thymic epithelial tumors: relationship with the current WHO classification systems
... Mutational ras protein can affect cell proliferation, cell cycle regulation and anti-apoptotic sig- nal by decreasing the activity of endogenous GTPase, or transcriptional decreasing the expression of Fas receptor ...
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Activated N-Ras signaling regulates arterial-venous specification in zebrafish
... (Additional file 5: Figure S8A), similar to the expression pattern of endogenous lmo2 gene (Figure 1D), and the expression of the human and zebrafish NRASD12 pro- teins was also confirmed via western blotting assay ...
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Dual sex specific functions of Drosophila Upstream of N ras in the control of X chromosome dosage compensation
... of N-ras (UNR) to sequences adjacent to the SXL binding sites in the 3 ⬘ UTR (Abaza et ...the N-terminal third of the protein carries most of the translational repression function in vitro (Abaza and ...
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Wild-type N-Ras complements mutant K-Ras in pancreatic cancer cell lines but K-Ras has a specific role in cell cycle independent regulation of G2 cyclins
... As previously mentioned, K-Ras can promote the upregulation of cyclins and so activation of key Cdks promoting the cell cycle. Previous work has suggested that K- Ras mainly functions through cyclin D, ...
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SKP2 cooperates with N-Ras or AKT to induce liver tumor development in mice
... of N-Ras (N-RasV12), AKT1 (myr-AKT1), or β-catenin (ΔN90-β-catenin) protooncogenes, via hydrodynamic gene ...SKP2, N-RasV12 or ΔN90-β-catenin alone as well as co-expression of SKP2 and ...
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Oncogenicity of human N-ras oncogene and proto-oncogene introduced into retroviral vectors.
... In order to study the in vitro and in vivo oncogenicity of N-ras and to compare its pathogenicity to that of H-ras, we have inserted an activated or a normal form of human N-ras cDNA int[r] ...
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Single-molecule diffusion measurements of H-Ras at the plasma membrane of live cells reveal microdomain localization upon activation
... of Ras: N-Ras, H-Ras and K- Ras, exist in human ...the Ras proteins. The minimal membrane anchor of Ras consists of the CAAX-motif, which is supplemented by one ...
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miR-98 functions as a tumor suppressor in salivary adenoid cystic carcinomas
... including N-RAS (1:50, Santa Cruz Biotech- nology), E-cadherin (1:2,500, BD Biosciences, San Jose, CA, USA), N-cadherin (1:250, BD Biosciences), vimentin (1:8,000, BD Biosciences), AKT (1:1,000, Cell ...
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... and N-RAS analyses were performed in our molec- ular pathology laboratory, and the following mutations were analyzed: CAA>CTA Q61L, CAA>CAT Q61H, CAA>CGA Q61R, GGT>GTT G12V, GGC>GAC G13D, ...
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Quantitative Analysis of Ras Oncogene Isoforms Using Decision Tree and Support Vector Machine
... oncogenic N-Ras or K-Ras when tested in a range of fibroblast-based transformation assays [5], ...regarding Ras gene studies; current studies on Ras isoforms have not succeeded in ...
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Mechanism of Nucleotide Exchange by Guanine Nucleotide Exchange Factors on the Ras Superfamily of Small G-Proteins
... free N-Ras ...the N-Ras peak showed a characteristic profile for ...free N-Ras remained bound to GDP despite dialysis overnight with EDTA and ...
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Cellular responses to oncogenic Ras signalling
... Although Ras proteins have been extensively studied for over 30 years, it is remains unclear how many Ras molecules are present in a cell, as well as which isoform is most ...cellular Ras abundance ...
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Roles of the Ras-MEK-Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase-Akt-mTOR Pathways in Jaagsiekte Sheep Retrovirus-Induced Transformation of Rodent Fibroblast and Epithelial Cell Lines
... the Ras-MEK-MAPK pathway in fibroblast trans- ...the Ras-MEK- MAPK pathway, because this pathway is frequently activated in oncogenically transformed ...the Ras-MEK- MAPK pathway at levels below ...
Defective DNA repair and chromatin organization in patients with quiescent systemic lupus erythematosus
... the N- ras locus strongly correlates with melphalan-induced apoptosis in PBMCs from healthy controls [22], the re- pair kinetics of N-ras-specific monoadducts were followed for up to 48 h ...
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Cancer cell killing by target antigen engagement with engineered complementary intracellular antibody single domains fused to pro-caspase3
... pelleted at 200 × g, 5 min at room temperature and resuspended in at total volume of 83 μ l (comprising 75 μ l PhiPhiLux reagent and 8 μ l FBS), and incubated for 30 min at 37 °C. Cells were washed in 1 ml PhiPhiLux ...
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A Role for the Noncatalytic N Terminus in the Function of Cdc25, a Saccharomyces cerevisiae Ras-Guanine Nucleotide Exchange Factor
... The N terminus of the in vivo function of wild-type Cdc25 is likely a re- mSos1 is characterized by the presence of a DH domain, sult of its interaction with endogenous Cdc25, thereby with only 30% similarity to ...
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X RAY DIFFRACTION STUDY OF A PANCHAVAKTRA RAS
... In the name of Panchavaktra ras, various formulations are available in ayurvedic texts. This formula is taken from well known Andhra Telugu book named Basavarajeeyam 1 , 6 th chapter (Vataroga nidana lakshana ...
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The neurotensin gene is a downstream target for Ras activation
... the Ras regulatory pathway plays a role in the expression of the neurotensin gene (NT/N), a terminally differentiated endocrine product specifically localized in the gastrointestinal tract to the adult ...
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Pathway to RAS
... Meanwhile in 1989, Aroian and Jane Mendel were trying to clone let-23, which lay in an ill-defined mega- base-sized region of chromosome II. Aroian mapped let-23 with Tc1 polymorphisms (using the method of R uvkun et al. ...
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