N-terminal pro-domain
The N Terminal Membrane Spanning Domain of the Escherichia coli DNA Translocase FtsK Hexamerizes at Midcell
... of pro- tein and DNA favor the maintenance of the hexameric state by ensuring a high “on” rate of translocase monomers to form hex- amers on DNA ...The N-terminal membrane-spanning domain was ...
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Leader Proteinase of the Beet Yellows Closterovirus: Mutation Analysis of the Function in Genome Amplification
... the N-terminal, nonproteolytic domain functions as an activa- tor of genome amplification ...proteinase domain provides any additional activity required for efficient RNA ...
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Characterization of the Bacillus subtilis Penicillin Binding Protein PBP4
... recombinant pro- tein of 453 residues after successful cleavage of the N-terminal ...C-terminal domain (comprising 92 residues) on the folding, stability or enzymatic activity of PBP4*, ...
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The Ancestral N Terminal Domain of Big Defensins Drives Bacterially Triggered Assembly into Antimicrobial Nanonets
... C-terminal domain and a globular hydrophobic ancestral N-terminal ...hydrophobic domain lost during evolution toward  ...we pro- duced the oyster Crassostrea gigas BigDef1 ...
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The Hypervariable Domain of the Murine Leukemia Virus Surface Protein Tolerates Large Insertions and Deletions, Enabling Development of a Retroviral Particle Display System
... envelope pro- teins (Env) consist of a peripheral, receptor-binding surface protein (SU) subunit and a membrane-spanning transmem- brane protein (TM) subunit that contains an N-terminal fusion ...the ...
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An androgen receptor N terminal domain antagonist for treating prostate cancer
... nous AR in LNCaP human prostate cancer cells transfected with the AR-driven PSA(6.1kb)-luciferase reporter, which is induced by the synthetic androgen R1881 (Figure 1B). Antiandrogens, such as bicalutamide and MDV3100, ...
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Adhesins in Human Fungal Pathogens: Glue with Plenty of Stick
... these pro- teins enable the fungus to bind to glycoproteins on the host cell ...contain N-terminal domains that exhibit weak similarity to the PA14 domains in ...effector domain, complexed to ...
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The bovine papillomavirus type 1 E2 transactivator and repressor proteins use different nuclear localization signals.
... transactivation domain is ...cytoplasmic pro- tein to the nucleus has also been found with the NLSs of other proteins (8), and it has been suggested that this may be due to improper presentation of the NLS ...
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Dissecting the Role of the N-Terminal Domain of Human Immunodeficiency Virus Integrase bytrans-Complementation Analysis
... an N-terminal domain of FIV IN can function in trans to an N-terminal deletion mutant of HIV-2 ...core domain of IN (57). Cross-complementation experiments show that the ...
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Crystal Structure of the Oligomerization Domain of the Phosphoprotein of Vesicular Stomatitis Virus
... central domain not only forms a stable dimer but also shows a potential tetrameric form, as observed in the noncrys- tallographic ...the N-RNA template and the additional N protein in the replicase ...
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Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
... the N-terminal regulatory region of the Src family ...its pro- posed function as a transactivator of a cellular tyrosine kinase, called Crk or CT10 regulator of a tyrosine ...SH3 domain (SH3C) ...
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Requirement of the N-Terminal Activation Domain of Herpes Simplex Virus ICP4 for Viral Gene Expression
... synthesized pro- teins were metabolically labeled and analyzed by SDS-PAGE, as described in Materials and ...the N-terminal transactivation domain and the C-terminal 520 amino acids, ...
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Leader Proteinase of Beet Yellows Virus Functions in Long-Distance Transport
... The papain-like leader proteinases provide a particularly illuminating example of the multifunctional viral proteins. These proteinases were found in a number of evolutionarily diverse lineages of the animal, fungal, and ...
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Ringer, Pia Sabrina (2018): Advancing molecular force measurements across talin. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Generation of FL-TSM. To generate the FL-based TSM, restric- tion sites were added to the cDNA of YPet (aa 1–228) (5Xho/ 3′BamHI) and mCherry (5′BamHI/3′NotI) by polymerase chain reaction (PCR), and PCR products were ...
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Intra-ER sorting of the peroxisomal membrane protein Pex3 relies on its luminal domain.
... The N-terminal 45 amino acid residues of ScPex3 contain the short luminal (17 amino acids) segment and the transmembrane segment followed by a few amino acid ...Pex3 domain has been shown to be ...
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Retroviral retargeting by envelopes expressing an N-terminal binding domain.
... Several strategies can be used to engineer retroviral enve- lopes with altered host range. Small modifications of the ret- roviral SU can be introduced by substitutions with linear pep- tides displaying binding ...
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N terminal domain of Prion Protein directs its Oligomeric Association
... The N-terminal region of prion protein (residues 23–90) is required for the for- mation of this distinct oligomer; a truncated form comprising residues 91–231 forms a broad distribution of aggregated spe- ...
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Prognostic Value of N Terminal Pro Brain Natriuretic Peptide in Acute Pulmonary Embolism
... vation of NT-pro BNP 24 hours after diagnosis (reduc- tion of less than 50% from initial values) predicts higher mortality at thirty days. Serial measurements of NT-pro BNP may provide additional prognostic ...
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Echocardiographic assessment and N-terminal pro-brain natriuretic peptide in hypertensives with metabolic syndrome
... serum levels of natriuretic peptides is observed in patients with impaired as well as preserved left ventricular systolic function, especially those with heart failure.. 3,4 However,.[r] ...
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The RNase III Family: A Conserved Structure and Expanding Functions in Eukaryotic dsRNA Metabolism
... coli RNase III is a two metal-binding enzyme (Steitz and Steitz, 1993) because of the conserved stretches of acidic amino acids observed in its nuclease domain. However, the actual association of these conserved ...
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