Naive T cell
Naive T cell survival and homeostasis analysis of monoclonal and polyclonal T cell populations
... the naive T cell clones that compose the peripheral pool is essential to understand the functioning o f the immune ...monoclonal T cell populations, obtained from TCR transgenic mice, ...
156
One naive T cell, multiple fates in CD8+ T cell differentiation
... of naive T cells occurs independently and simultaneously in the lymph nodes that drain the two separate sites of antigenic challenge (Schepers et ...activated T cells are still largely con- fined to ...
12
Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery
... peripheral naive T cell pool requires that an existing T cell must die if a new T cell is generated in the thymus or by peripheral cell division (Tanchot and Rocha ...
36
Fate of a Naive T Cell: A Stochastic Journey
... of T cell populations depends on migration, division and death of individual cells ...(1). T cells migrate between spatial compartments (spleen, lymph nodes, lung, liver, ...fluorescence-activated ...
13
Outcomes of acute leukemia patients transplanted with naive T cell–depleted stem cell grafts
... in T N -depleted recipients, without a major effect on the occurrence of ...models, T EM consistently cause little to no GVHD, but we found that T CM could cause GVHD, albeit milder than T N , ...
14
CD8 naive T cell counts decrease progressively in HIV infected adults
... CD8 naive T cells are depleted during the asymptomatic stage of HIV ...CD8 T cell numbers are increased during this stage, the naive CD8 T cells are progressively lost and fall ...
7
Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion
... mRNA from individual sorted cells isolated from pooled LN and spleen of naive B6 mice was reverse transcribed followed by 2 rounds of nest- ed TRBV13-1–specific PCR amplification. The PCR products were puri- fied ...
11
Emerging mechanisms of immune regulation: the extended B7 family and regulatory T cells
... regulate T cell activities is perhaps one of the most intensely investigated areas in ...CD28/cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) families of molecules, and the revival of regulatory ...
7
Increased replication of CD4+ naive T cells and changes in T cell homeostasis in a case of acute exacerbation of juvenile idiopathic arthritis: a case comparison study
... expressing T cells during acute exacerbation in our pa- ...Chronic T cell stimulation induces in- creased T cell turnover in patients with JIA, as demon- strated by age-inappropriate ...
8
Juxtaposition of system dynamics and agent based simulation for a case study in immunosenescence
... with naive T cell populations presented in ...the naive T cell populations over ...different naive T cells populations with ...the naive depletion case study ...
20
Atypical Human Effector/Memory CD4(+) T Cells With a Naive-Like Phenotype
... the naive T cell pool was discovered in terms of surface marker expression, cytokine production, or transcriptomic ...single cell level combined with a better understanding of the generation ...
6
Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics
... baseline T-cell immunity against common viruses and immunogenic ...that T-cell precursor frequencies between neonates tended to cluster by Ag ...the naive Ag- specific ...
9
Aging promotes acquisition of naive like CD8+ memory T cell traits and enhanced functionalities
... Protective T cell memory is an acquired trait that is contingent upon the preservation of its constituents and therefore vulnerable to the potentially deleterious effects of organismal ...long-term T ...
20
Neonatal thymectomy reveals differentiation and plasticity within human naive T cells
... of naive T cells are derived from peripheral T cell renewal (4, ...restored naive T cell numbers, naive T cell function, and phenotype, while even a ...
12
The regulatory roles of neutrophils in adaptive immunity
... with a hypoplastic MZ in mice [34]. During S. pneumo- niae infection, resident immature Ly6G intermediate neutro- phils in mouse spleens undergo emergency proliferation and mobilization from the splenic niche to increase ...
11
Role of Thymic Output in Regulating CD8 T-Cell Homeostasis during Acute and Chronic Viral Infection
... CD8 T cells to acti- vation-induced cell death and possibly replicative senescence (6, 8, 9, 33, ...of naive CD8 T cells is needed as “reinforcement” to maintain CD8 T-cell ...
11
A comprehensive characterization of aggravated aging-related changes in T lymphocytes and monocytes in end-stage renal disease: the iESRD study
... aging-related T cell subset that had been reported to increase during ...immunosenescent T cell differenti- ation (especially in CD8+ T cells) and higher levels of intermediate ...
10
Multiple sclerosis
... to naive T cells in the context of co-stimulatory ...these naive autoreactive T cells to a Th1 or Th17 cell phenotype; howev- er, these potentially pathogenic T cells are not ...
10
Naive CD4 T-cell activation identifies MS patients having rapid transition to progressive MS
... in naive CD4 T-cell biology, identified by unsupervised hierarchical clustering, segregated patients with SPMS into 2 significantly reproducible ...that naive CD4 T-cell ...
13
Key roles for lipid mediators in the adaptive immune response
... B cell functions was the dis- covery that B cells express the ALX/FPR2 receptor that recognizes the D-series resolvins, RvD1 and RvD3 ...B cell functions in mice by increasing antibody production and B ...
9