Nausea reported in the randomised controlled trials
The fading of reported effectiveness. A meta-analysis of randomised controlled trials
... of reported correlations with publication date (best model: P < ...drug trials to examine the reported effectiveness of medical treatments over ...as reported in RCTs, changes with ...
12
Increasing recruitment to randomised trials: a review of randomised controlled trials
... percentage randomised. Within patient preference trials, patients may be placed within one of three groups according to their preferences: 1) patients with no strong preference and consent to ran- ...
9
Dentures for randomised controlled trials
... is randomised so that half the dentures with a red dot were from the alginate side of the trial and half the red dots were from the silicone side of the ...
13
Recruitment to randomised controlled trials with children
... and provide cure for their ailment (Huizinga et al. 1999, Moritz et al. 2002, Kemeny et al. 2003) and in the hope of receiving extra monitoring, better care and treatment from doctors and nursing staff (Mingus et al. ...
373
The possibility of critical realist randomised controlled trials
... As has been previously been pointed out by the defenders of realist RCTs [27] in response to the accus- ation that RCT design is inherently positivist [18], methods do not make assumptions, researchers (and we might add ...
8
Investigating causal mechanisms in randomised controlled trials
... However, the mediator-outcome effect can be confounded because the mediator is not randomised. After adjusting for measured confounders, sensitivity analyses can be used to assess the degree to which the estimated ...
5
Impact of tocilizumab monotherapy on patient reported outcomes in patients with rheumatoid arthritis from two randomised controlled trials
... few trials examining the impact of TCZ monotherapy on PROs in patients with RA, with the majority of available data limited to the PROs included in the American College of Rheumatology (ACR) core set (PtGA, pain ...
9
Impact of tocilizumab monotherapy on patient reported outcomes in patients with rheumatoid arthritis from two randomised controlled trials
... few trials examining the impact of TCZ monotherapy on PROs in patients with RA, with the majority of available data limited to the PROs included in the American College of Rheumatology (ACR) core set (PtGA, pain ...
9
Serious adverse events reported in placebo randomised controlled trials of oral naltrexone: a systematic review and meta-analysis
... clinical trials of LDN have been con- ducted in, for example, Crohn ’ s disease, multiple sclerosis, fibromyalgia and HIV infection, where the evidence has shown efficacy and/or low toxicity ...awaiting ...
13
Design, analysis and presentation of factorial randomised controlled trials
... Factorial trials require special considerations, however, particularly at the design and analysis ...Factorial trials are most often powered to detect the main effects of interventions, since adequate power ...
5
Randomised Controlled Trials, Evidence Hierarchies and Smarter Choices
... Goodwin, P. (2011) Can Travel’s Random Elements be Controlled? Local Transport Today. 564 . ing whether a cause-effect relationship exists. The conditions required for gen- eralising findings about the magnitude ...
8
Can “realist” randomised controlled trials be genuinely realist?
... Randomized controlled trials, Realist evaluation, Scientific realism, Causation Background In October 2015, Jamal and colleagues [1] published a paper on realist randomised controlled ...
6
Should desperate volunteers be included in randomised controlled trials?
... in trials, these are not arbitrary but rather are those that experience suggests lead to reliable results in well run RCTs; those that allow for early misleading ...
30
An assessment of the quality of randomised controlled trials conducted in China
... of randomised controlled trials (RCTs) conducted in China and published in 2004 was undertaken to describe their characteristics, assess the quality of their reporting, and where possible, the ...
8
Missing data in randomised controlled trials: a practical guide
... Although Bayesian approaches are gaining ground in the analysis of clinical trials ( Spiegelhal- ter et al. , 2003 ), a frequentist approach still predominates. Thus this monograph mainly adopts a frequentist ...
207
A guide to performing a peer review of randomised controlled trials
... Reporting guideline checklists follow the flow of the paper, presenting items in approximately the order encoun- tered, from the Introduction through to Discussion (Fig. 2). Many, but not all journals require that ...
7
Randomised controlled trials of attentional bias retraining in smokers
... Although an additional two practices in HoB tPCT expressed an interest in the study, we did not pursue patient recruitment any further at this site for three reasons. Firstly, given the poor response rate from the ...
415
Trials and tribulations : challenges and prospects for randomised controlled trials of social work with children
... for randomised controlled trials of social work with children Abstract Randomised controlled trials (RCTs) have rarely been used in evaluations of social work interventions with ...
27
Sample Size Justifications for Pilot Trials of Publicly Funded Randomised Controlled Trials
... The simplest design for a trial in terms of the comparison of treatment groups is for them to be run in parallel to each other so that if two treatments are under investigation there will be two groups running ...
381
Modelling departure from randomised treatment in randomised controlled trials with survival outcomes
... oncology trials, and in particular whether trials should be allowed to base their conclusions on shorter-term outcomes like PFS rather than ultimate long term outcomes such as OS, was sparked by the ...
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