Nd/sub 5/Fe/sub 17/D/sub 15.5/
The effect of magnetic nanoparticles of Fe<sub>3</sub>O<sub>4</sub> on immune function in normal ICR mice
... suspension was placed in a 96-well microtiter plate in 200 µ L aliquots, and cultured in the presence or absence of T-cell mitogen (concanavalin A [ConA], Sigma, USA) (5 µ g/mL). Meanwhile the wells receiving ...
7
Reversal of multidrug resistance by magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticle copolymerizating daunorubicin and 5-bromotetrandrine in xenograft nude-mice
... patients with malignant tumor die of MDR. A diverse range of agents involved in MDR include alkaloid compounds and bacterial and fungal antibiotics such as anthracyclines and etoposide. An accepted mechanism of MDR is a ...
6
Effect of interaction of magnetic nanoparticles of Fe<sub>3</sub>O<sub>4</sub> and artesunate on apoptosis of K562 cells
... Based on the results of cytotoxicity assay, the best combina- tion condition of ART with MNPs-Fe 3 O 4 (100:1 M/M) was used to measure the apoptosis rate. Briefly, after being treated with ART, MNPs-Fe 3 O ...
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Biocompatibility of magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles and their cytotoxic effect on MCF-7 cells
... Elemental analysis was performed using scanning electron microscopy-energy dispersive x-ray spectroscopy (SEM-EDS, EDAX 9100; EDAX International, Prairie View, IL). X-ray diffraction data were collected using an XD-D1 ...
10
Preparation of Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticles coated with gallic acid for drug delivery
... The in vitro bioassay, as shown in Figure 9, tells us that, after 72 hours of treatment, neither gallic acid nor FCG was toxic to a normal human fibroblast (3T3) cell line tested using various doses (0.47, 0.94, 1.88, ...
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Fe<sub>3</sub>O<sub>4</sub>-based PLGA nanoparticles as MR contrast agents for the detection of thrombosis
... ± 15% humidity, and 12 h light/dark cycle) and had free access to water and ...Then, Fe 3 O 4 -PLGA or Fe 3 O 4 -PLGA-cRGD NPs at a final dosage of 1 mg lyophilized powder dissolving 1 mL phosphate- ...
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Multifunctional magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles combined with chemotherapy and hyperthermia to overcome multidrug resistance
... and 5-Br-Tet from Fe 3 O 4 ...with Fe 3 O 4 ...with 5-BrTet only decreased the speed of tumor growth and had much less effect on overcoming multidrug resistance than did Fe 3 O 4 - ...
9
Biosafety evaluation of Janus Fe<sub>3</sub>O<sub>4</sub>-TiO<sub>2</sub> nanoparticles in Sprague Dawley rats after intravenous injection
... the 15 mg/kg Fe 3 O 4 -TiO 2 NP group, liver coefficients of rats were significantly higher than the control ...the 5 mg/kg TiO 2 NP-treatment ...
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The changes of T lymphocytes and cytokines in ICR mice fed with Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticles
... cells/mL with RPMI-1640. The adjusted cells were placed in a 96-well microtiter plate in 200 µ L aliquots and cultured in the presence of T-lymphocytes mitogen (5 µ g/mL Con- canavalin A [ConA]) (Sigma Chemical ...
6
Pharmacokinetic parameters and tissue distribution of magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles in mice
... ± 15 µ g/g at six hours after dosing, and then decreased ...of Fe 3 O 4 MNPs were higher in the liver and spleen than those in other ...for Fe 3 O 4 ...
6
Biological responses to core–shell-structured Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>-NH<sub>2</sub> nanoparticles in rats by a nuclear magnetic resonance-based metabonomic strategy
... aa, acetoacetate; ab, anabasine; ace, acetate; ach, acetylcholine; aco, aconitate; act, acetone; aD, acetamide; ah, aminohippurate; ala, alanine; all, allantoin; arg, arginine; asn, asparagine; Ben, benzoate; Bet, ...
16
Role of 5-HT<sub>2A</sub> receptor antagonists in the treatment of insomnia
... Among 5-HT 2A receptor antagonists, eplivanserin was the most advanced compound in ...other 5-HT 2A receptor antagonists appear to support the involvement of the 5-HT 2A receptor mechanism in ...
12
The effects of magnetite (Fe<sub>3</sub>O<sub>4</sub>) nanoparticles on electroporation-induced inward currents in pituitary tumor (GH<sub>3</sub>) cells and in RAW 264.7 macrophages
... to Fe 3 O 4 NPs (100 µ g/mL), there was a progressive decrease in the activity of MEP-induced channels, which occurred at the level of hyperpolarizing potentials ranging between − 80 and − 200 ...of Fe 3 O ...
10
Preparation and in vitro evaluation of doxorubicin-loaded Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticles modified with biocompatible copolymers
... encapsulate Fe 3 O 4 nanoparticles by an emulsion method ...the Fe 3 O 4 ...and Fe 3 O 4 -PLGA-PEG nanoparticles had no cytotoxicity and were ...loaded Fe 3 O 4 magnetic nanoparticles modif ...
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Effect of magnetic nanoparticles of Fe<sub>3</sub>O<sub>4 </sub>and 5-bromotetrandrine on reversal of multidrug resistance in K562/A02 leukemic cells
... of 5% CO 2 , and passaged every two ...with 15% FCS, 100 ng/mL granulocyte colony-stimulating factor (G-CSF) 12 at 37 °C in a humidified atmosphere of ...
8
Magnetic nanoparticles of Fe<sub>3</sub>O<sub>4</sub> enhance docetaxel-induced prostate cancer cell death
... MgNPs-Fe 3 O 4 alone reduced the viability of LNCaP and PC-3 cells, but had little or no effect on the viability of DU145 and PrSC cells (Figure 5). These results suggest that the cytotoxicity of ...
10
Synthesis of composite magnetic nanoparticles Fe<sub>3</sub>O<sub>4</sub> with alendronate for osteoporosis treatment
... When Fe 3 O 4 was cultured with OBs and OCs under RF exposure, the cell survival rate declined to ~ ...of Fe 3 O 4 will overheat the cells when exposed to ...
12
Fe<sub>3</sub>O<sub>4</sub>/Au magnetic nanoparticle amplification strategies for ultrasensitive electrochemical immunoassay of alfa-fetoprotein
... composite Fe 3 O 4 /Au nanoparticles were synthesized by assembling gold nanoparticles on SH-modified Fe 3 O 4 and using them as nanocarriers for immobilization of HRP and a secondary antibody (Ab 2 ...to ...
11
Immobilized transferrin Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub> nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery
... The procedures for generation and drug loading of TfDMP are shown in Figure 1. By coupling GA with amino- immobilized Fe 3 O 4 @SiO 2 , the surface of the magnetic nanoparticle can be modified with both carboxyl ...
9
Polyetherimide-grafted Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub> nanoparticles as theranostic agents for simultaneous VEGF siRNA delivery and magnetic resonance cell imaging
... (Figure 5) at room temperature (about 300 ...of Fe 3 O 4 @SiO 2 ...the Fe 3 O 4 @SiO 2 and Fe 3 O 4 @SiO 2 /PEI ...the Fe 3 O 4 @SiO 2 and Fe 3 O 4 @SiO 2 /PEI were attracted ...
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