Negative Regulator
TRIM13 Is a Negative Regulator of MDA5-Mediated Type I Interferon Production
... Trim59 expression was relatively unaltered in Trim13 ⫺/⫺ BMDMs under various stimulation conditions (Fig. 4e and f), indicating that the expression of Trim13 and Trim59 is indepen- dently regulated. As the expression of ...
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The Negative Regulator of Splicing Element of Rous Sarcoma Virus Promotes Polyadenylation
... The Rous sarcoma virus gag gene contains a cis-acting negative regulator of splicing (NRS) element that is implicated in viral polyadenylation regulation. To study the mechanism of polyadenylation promotion ...
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Sox2 function as a negative regulator to control HAMP expression
... In the present study, we found that overexpression of Sox2 can decrease HAMP expression in hepatoma derived cells, and Sox2 can further downregulate IL-6 or BMP-2 induced HAMP expression in these cells (Additional file ...
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SOCS1 is a negative regulator of metabolic reprogramming during sepsis
... SOCS1 is a pleiotropic inhibitor of the inflammatory response, and can prevent activation of pathogen recognition receptors, cytokine receptors, and growth factors (15–17, 46–48). SOCS1 is known to act at different steps ...
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The cytolinker Pigs is a direct target and a negative regulator of Notch signalling
... The ChIP data and reporter assays indicate that Pigs is directly regulated by Notch in at least some tissues, and in both the muscles and the ovaries, the phenotypes are compatible with Pigs being an effector of Notch. ...
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PRL2 serves as a negative regulator in cell adaptation to oxidative stress
... High levels of ROS cause oxidative stress, which plays a critical role in cell death. As a ROS effector protein, PRL2 senses ROS and controls phagocyte bactericidal activity during infection. Here we report PRL2 ...
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Jjj1 Is a Negative Regulator of Pdr1-Mediated Fluconazole Resistance in Candida glabrata
... ABSTRACT The high prevalence of fluconazole resistance among clinical isolates of Candida glabrata has greatly hampered the utility of fluconazole for the treatment of invasive candidiasis. Fluconazole resistance in this ...
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GABA exists as a negative regulator of cell proliferation in spermaogonial stem cells
... The transformation of gonocytes into SSCs is complete 6 dpp in mice [23]. At this young age, undifferentiated spermatogonia are the only germ cells present in the seminiferous tubules. We first assessed the production of ...
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Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin
... Gsk3b by ectopic kinase dead Gsk3b [5]. Therefore, we hypothesized that Gtpbp2 might be affecting Wnt signal- ing at the level of the destruction complex via negative regulation of Axin protein levels. We examined ...
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Paxillin is an intrinsic negative regulator of platelet activation in mice
... Intrinsic negative regulators of platelet activation have been identi- fied recently, but many of these proteins only control a specific receptor signaling ...a regulator of G-protein signaling to the Giα ...
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Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis
... To address the biological functions of PGCP in liver cancer progression, SK-Hep1 cells were transfected with PGCP siRNA (siPGCP), and then RNA sequencing was employed to compare the global gene expression profiles of ...
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Epstein-Barr virus BZLF1 transactivator is a negative regulator of Jun.
... These results and those of previous studies of Epstein-Barr virus promoters regulated by BZLF1 indicate that BZLF1 requires adjacent multiple DNA-binding sites for cooperative interactio[r] ...
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Nkx3 2/Bapx1 acts as a negative regulator of chondrocyte maturation
... Our findings indicate that PTHrP signals are necessary and sufficient to maintain the expression of Nkx3.2/Bapx1 in the proliferative region of the growth plate, and suggest that Nkx3.2/B[r] ...
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BIGH3: A Negative Regulator of Human Osteosarcoma Large Multicellular Spheroids
... By day 5, small MTS only were observed in medium containing BIGH3 Figure 2e when compared to non-treated cells that formed a large MTS from juxtaposed smaller aggregates of cells Figure [r] ...
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miR-141-3p is a key negative regulator of the EGFR pathway in osteosarcoma
... Methods: Western blot, real-time PCR and immunohistochemical were used to detect the expression of EGFR and miR-141 in osteosarcoma tissues and cells. The correlation between miR-141 and the grading of osteosarcoma and ...
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RNase L is a negative regulator of cell migration
... In transwell assays, migration of the RNase L knockdown cell lines in response to either fibronectin or serum was increased by 250% and 114%, respectively, compared to the control cells [r] ...
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C/EBPbeta is a negative regulator of human papillomavirus type 11 in keratinocytes.
... C HFKs, stably transfected with HPV11 DNA, were untreated or treated with nonspecific C/EBPa containing the consensus binding motif at nt 7429 to 7436 in HPV11 or C/EBPb dumbbells for 7 [r] ...
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FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues
... Dorsal and lateral cell fates marked by Pax3 and Pax6, respectively are excluded from the ventral neural tube of wild-type and Fkbp8–/– embryos but were expressed across the ventral midl[r] ...
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SIP1 is a catabolite repression-specific negative regulator of GAL gene expression.
... zyme activity in cells bearing multiple copies of SIP1 reflected reduced transcription of the GAL1 gene. The Northern blot is illustrated in Figure 2A. Densitometric analysis [r] ...
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PTEN is a negative regulator of mitotic checkpoint complex during the cell cycle
... chromosomal aberrations, and aneuploidy [36–38]. In fact, nuclear abnormalities are reliable biomarkers for detecting arsenic exposure and its toxicity [36–37]. Well- controlled studies in rodent cells also demonstrate ...
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