Neointimal formation
S100B is required for maintaining an intermediate state with double-positive Sca-1+ progenitor and vascular smooth muscle cells during neointimal formation
... Methods and results: The neointimal formation model in rats was established by carotid artery balloon injury using a 2F-Forgaty catheter. Most Sca-1+ cells first appeared at the adventitia of the vascular ...
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Use of rosiglitazone before and after vascular injury in hypercholesterolemic rabbits: Assessment of neointimal formation
... NI formation and macro- phage content in a mouse injury model [1] and in hyper- cholesterolemic rabbits ...on neointimal formation administered at different times in hypercholesterolemic rabbits ...
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<p>Nanofibrous vildagliptin-eluting stents enhance re-endothelialization and reduce neointimal formation in diabetes: in vitro and in vivo</p>
... Figure 4 H&E staining of vessel sections after eight weeks (×200). The degradable nanofibrous membranes coated outside of implanted stents were noticed between dotted line and double arrow. Inflammation response was ...
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Stimulation of activin A expression in rat aortic smooth muscle cells by thrombin and angiotensin II correlates with neointimal formation in vivo
... Vasoactive GTP-binding protein–coupled receptor agonists (e.g., angiotensin II [AII] and a -thrombin) stimulate the production of mitogenic factors from vascular smooth mus- cle cells. In experiments to identify mitogens ...
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Fimasartan reduces neointimal formation and inflammation after carotid arterial injury in apolipoprotein E knockout mice
... and neointimal formation through interactions between Fas/Fas ligands, inducing the lysis of SMCs (Henderson et ...or formation of aneurysms (Kyaw et ...
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Propylthiouracil-coated biodegradable polymer inhibited neointimal formation and enhanced re-endothelialization after vascular injury
... Materials and methods: This study used a biodegradable polymer coating with PTU to test its effects on platelet function, re-endothelialization, and neointimal formation after vascular injury. ...
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Sequence independent inhibition of in vitro vascular smooth muscle cell proliferation, migration, and in vivo neointimal formation by phosphorothioate oligodeoxynucleotides
... SMC in vitro and in vivo. S-dC28 inhibited human aortic SMC proliferation in vitro induced by 10% FBS as well as by the mi- togens PDGF, bFGF, and EGF. S-dC28 also inhibited PDGF induction of human aortic SMC ...
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Perivascular mast cells regulate vein graft neointimal formation and remodeling
... restored neointimal formation to that seen in normal ...promoting neointimal formation by inducing local early acute inflammatory and proliferative responses, and suggest vein graft ex vivo MC ...
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Differentiated vascular myocytes: are they involved in neointimal formation?
... in neointimal formation in canine carotid artery was ...of neointimal cells from injured carotid arteries indicated they were morphologically and immunologically identical to cultured type 2 ...for ...
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Comparison of reendothelialization and neointimal formation with stents coated with antibodies against endoglin and CD34 in a porcine model
... Abstract: Anti-CD34 coated stents are the only commercialized antibody-coated stents currently used for coronary artery diseases with various limitations. Endoglin plays important roles in the proliferation of ...
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Original Article Histological validation of frequency domain optical coherence tomography for the evaluation of neointimal formation after a novel polymer-free sirolimus-eluting stent implantation
... However, neointimal coverage after polymer-free DES implantation is unclear and validation between optical co- herence tomography (OCT) and histology is ...area, neointimal area and neointimal ...
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Decreased neointimal formation in Mac 1–/– mice reveals a role for inflammation in vascular repair after angioplasty
... timal formation, we subjected mice lacking Mac-1 to a novel form of mechanical carotid artery dilation and complete endothelial ...reduced neointimal thickening after vascular ...in neointimal ...
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MiR-93 regulates vascular smooth muscle cell proliferation, and neointimal formation through targeting Mfn2
... vascular injury has not been explored. To further confirm these results in vitro, we treated VSMC primary cells with PDGF-BB to promote cell proliferation. Interestingly, miR-93 expression was dose- and time-dependently ...
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Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan mediated neointimal formation in the ductus arteriosus
... In addition to the well-known vasodilatory role of PGE, our find- ings indicate that chronic PGE stimulation via EP4 during gesta- tion induces vascular remodeling of the DA to promote neointimal cushion ...
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Exosomes derived from mesenchymal stem cells inhibit neointimal hyperplasia by activating the Erk1/2 signalling pathway in rats
... It has been known that the proliferation and migration of smooth muscle cells is exceedingly significant for the initiation and progression of neointimal hyperplasia, but the effects of endothelial cells have also ...
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Oversizing of Self Expanding Stents: Influence on the Development of Neointimal Hyperplasia of the Carotid Artery in a Canine Model
... patency, neointimal formation, and ...and neointimal thicknesses when they compared single and tandem stents implanted in the iliac arteries of ...
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Adenovirus-Mediated Gene Transfer of microRNA-21 Sponge Inhibits Neointimal Hyperplasia in Rat Vein Grafts
... various cardiovascular diseases and have become an intriguing target for therapeutic intervention, and investigating the role of miRNAs in cardiovascular disease is a new dimension for cardiovascular research. ...
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Central role of RAGE dependent neointimal expansion in arterial restenosis
... phase of cellular proliferation in the repairing arterial segment (42, 43). To study these cascades, phosphory- lation of Erk1/2 and protein kinase B (PKB), the latter a downstream target of PI3K (44), was assessed. ...
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Comparisons of the Effects of Stent Eccentricity on the Neointimal Hyperplasia between Sirolimus Eluting Stent versus Paclitaxel Eluting Stent
... tricity (SE). SE is defined as minimum stent diameter (D1) divided by maximum stent diameter (D1’). Outer lager circle and smaller circle on each slice mean EEM and stent CSA, respectively. (A) SE-NIH was determined at ...
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Ca2+ signaling in fowl aortic smooth muscle increases during maturation but is impaired in neointimal plaques
... Neointimal lesions develop spontaneously in young chickens prior to sexual maturation as well as in blood vessels in which endothelial injury was evoked by a balloon catheter (Madison and Nishimura, 1994; A. B. ...
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