Neoplastic transformation
Resistance to neoplastic transformation of ex-vivo expanded human mesenchymal stromal cells after exposure to supramaximal physical and chemical stress
... to neoplastic transformation [16, 17, 18, ...malignant transformation is likely to be an uncommon event in huMSCs ex vivo expanded in standard, plastic-adherent culture conditions and in the presence ...
14
A link between c Myc mediated transcriptional repression and neoplastic transformation
... Recent studies indicate that the transcription factor c-Myc contributes to oncogenesis by altering the expression of genes involved in cell proliferation, but its precise function in neoplasia remains ambiguous. The ...
10
Alteration of cell cycle kinase complexes in human papillomavirus E6- and E7-expressing fibroblasts precedes neoplastic transformation.
... No effects with low-risk viral oncoproteins. It should be noted that all alterations of cyclin-CDK complexes described here are specific to the oncogenic form of viral proteins that were derived from high-risk types of ...
10
Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells
... Exposure to the growth factors present in culture media for ex vivo expansion could lead to activation of oncogenic transcription factors triggering neoplastic transformation of the MSC. Available protocols ...
18
The Influence of Propionate on the Spectrum of Short-Chain Fatty Acids in Cervical Cells During Dis- and Neoplastic Transformation
... Cervical tissue fragments received by target biopsy or intraoperatively under morphological control served as samples for the research. According to histological examination, each tissue fragment was divided into two ...
6
Speeding through cell cycle roadblocks: Nuclear cyclin D1-dependent kinase and neoplastic transformation
... many tumor types, simple over-expression of wild type cyclin D1 is insufficient to drive neoplastic transformation [15]. In contrast, cyclin D1 mutants refractory to phos- phorylation and subsequent ...
6
Neoplastic transformation of human thyroid epithelial cells by ionizing radiation
... pts, neoplastic transformation of hum an cells in culture by chemical means has not been readily ...of neoplastic transform ation of norm al hum an cells by a chem ical carcinogen was published in ...
246
suppresses microRNA expression and deregulates target oncogenes that cause neoplastic transformation in NIH3T3 cells
... drive neoplastic transformation of NIH3T3 cells, whether they can drive neoplastic transformation of human cells and what are the underlying mechanisms need to be ...
12
Neoplastic transformation of rat liver epithelial cells is enhanced by non-transferrin-bound iron
... on neoplastic transformation are not under- ...reported transformation-related effects of iron adminis- tered in a form that is present in ...
10
MicroRNAs involved in neoplastic transformation of liver cancer stem cells
... stem cells, and can be used to identify them. In fact, the specific markers of many somatic stem cells, e.g., HSCs, are still unidentified, and it is difficult to screen putative stem cell markers useful for isolation ...
10
Neoplastic transformation of cultured Syrian hamster embryo cells by DNA of herpes simplex virus type 2.
... TS'O' Division of Biophysics' and Department of Comparative Medicine,2 The Johns Hopkins University Schools of Hygiene and Public Health and Medicine, Baltimore, Maryland 21205 Syrian ha[r] ...
6
LDOC1 silenced by cigarette exposure and involved in oral neoplastic transformation
... According to the smoking history of DOK’s donor, the differentially expressed genes (DEGs) in DOK compared to normal human oral keratinocytes (HOK) may suggest a list of genes affected by long-term cigarette exposure and ...
14
Neoplastic Transformation-Associated Stimulation of the In Vitro Resolution of Concatemer Junction Fragments from Minute Virus of Mice DNA
... of transformation-dependent cellular factors in this ...the transformation dependency of MVM DNA amplification results from the stimulated replication of double-stranded ...a transformation-sensi- ...
7
Mutation in the polyomavirus genome that activates the properties of large T associated with neoplastic transformation.
... This toxicity of large T has been observed in several instances 14, 18 and could very well explain why simultaneous transfer of both pmt and plt genes failed to induce tumors in vivo Tab[r] ...
8
Cellular ras gene activity is required for full neoplastic transformation by polyomavirus.
... In this report, we show that Ras deficiency suppressed parts of the transformed phenotype of C3H1OT1/2 cells expressing the early region of polyomavirus, such as accelerated proliferatio[r] ...
8
Neoplastic Transformation of Human Small Airway Epithelial Cells Induced by Arsenic
... Because change in cell adhesion char- acteristics may imply change in integrin function, which plays an essential role in cell attachment, we examined the ex- pression of various integrin receptor functions in control ...
9
Neoplastic transformation of p16INK4a - deficient human fibroblast by co-operating cellular oncogenes.
... the transformation o f p l6 ^ ^ ‘*^-deficient ...for transformation, and substitute altered forms o f them ...on transformation (Davies et ...
201
Novel viruses: Update on the significance of papillomavirus infections in cats
... Papillomaviruses may cause a proportion of cutaneous squamous cell carcinomas and basal cell carcinomas, although the role of the virus in neoplastic transformation is currently unclea[r] ...
23
Transfer of malignant trait to immortalized human cells following exposure to human cancer serum
... several types of human tumours [10,12,29-33]. These factors permit lateral or horizontal transfer of onco- genic traits to target susceptible cells by activating sur- vival and mitogenic signals [18-20,29,34,35]. ...
12
P cadherin expression in breast cancer: a review
... and neoplastic transformation, the relative functional role played by P-cadherin in breast cancer cell invasion and motility is not fully elucidated ...
12