NEP, neutral endopeptidase
Inverse baseline expression pattern of the NEP/neuropeptides and NFκB/proteasome pathways in androgen-dependent and androgen-independent prostate cancer cells
... 6; NEP: neutral endopeptidase, CD10; NF κ B: nuclear factor kappa B; NP: neuropeptide; PBS: phosphate buffer saline; PC: prostate cancer; PSA: prostate-specific antigen; PVDF: polyvinylidene ...
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Cigarette smoke induces bronchoconstrictor hyperresponsiveness to substance P and inactivates airway neutral endopeptidase in the guinea pig Possible role of free radicals
... endopeptidase (NEP). After exposure to air or to cigarette smoke we measured the change in total pulmonary resistance (RL) induced by increasing concentrations of aerosolized substance P in the absence or ...
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Neutral endopeptidase 24 11 in neutrophils modulates protective effects of natriuretic peptides against neutrophils induced endothelial cytotoxity
... of NEP enzymatic activity and surface expression of ...their NEP enzymatic activity. When neutrophil surface expression of NEP/ CD10 was examined by fluorescence-activated cell sorter (FACS ® ...
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Angiotensin inhibition potentiates the renal responses to neutral endopeptidase inhibition in dogs with congestive heart failure
... to NEP-I, supporting the concept that intrarenal angiotensin antagonism, rather than improved systemic hemodynamics or potentiation of other peptide systems, mediated the enhanced renal responses to NEP-I ...
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Dual endothelin-converting enzyme/neutral endopeptidase blockade in rats with D-galactosamine-induced liver failure
... the liver cell damage seen in acute liver failure is not only due to direct effects of the precipitating drug, toxin, viral or other cause, but also due to a secondary release of proinflammatory and cytotoxic mediators ...
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Common acute lymphoblastic leukemia antigen expressed on leukemia and melanoma cell lines has neutral endopeptidase activity
... to NEP (135A3) or CALLA (44C10). mRNAs hybridizing to a NEP-specific probe were present in CALLA+ leukemia and melanoma cell lines, but absent from CALLA- ...lines. NEP enzymatic activity was ...
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Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signaling
... surface NEP protein also inhibited FAK phosphoryla- tion and cell migration although to a lesser degree than observed following expression of wild-type ...of NEP action distinct from its enzymatic function, ...
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CD10/neutral endopeptidase 24 11 in developing human fetal lung Patterns of expression and modulation of peptide mediated proliferation
... The cell membrane-associated enzyme CD10/neutral endopeptidase 24.11 (CD10/NEP) functions in multiple organ systems to downregulate responses to peptide hormones. Recently, CD10/NEP was found ...
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Prognostic significance of the combined expression of neutral endopeptidase and dipeptidyl peptidase IV in intrahepatic cholangiocarcinoma patients after surgery resection
... an additional 20 minutes at room temperature. Subsequently, the slides were incubated overnight with the primary antibodies against anti-NEP mouse monoclonal antibody (#sc-46656; Santa Cruz Biotechnology, Inc., ...
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Expression of neutral endopeptidase activity during clinical and experimental acute lung injury
... Neutral endopeptidase (NEP; EC ...of NEP in the limita- tion of pro-inflammation has been studied, using selective inhibitors and gene deletion in ...mice. NEP-deficient mice develop ...
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Neutral endopeptidase and kininase II mediate glucocorticoid inhibition of neurogenic inflammation in the rat trachea
... nonpeptide inflammatory mediator, platelet-activating factor (PAF), which is not degraded by NEP or ACE. Adult male pathogen-free F344 rats were treated for 2 d with dexamethasone (0.5 mg/kg per d i.p.), or with ...
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Toluene diisocyanate increases airway responsiveness to substance P and decreases airway neutral endopeptidase
... Substance P and related tachykinins contribute to the airway hyperresponsiveness caused by toluene diisocyanate (TDI) in guinea pigs. Neutral endopeptidase (NEP) is an important modulator of ...
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Neutral endopeptidase inhibitors potentiate substance P and capsaicin induced cough in awake guinea pigs
... investigator did not know whether substance P or diluent alone was aerosolized, substance P (10(-16) M) caused cough. Leucine-thiorphan (10(-5) M) and phosphoramidon (10(-5) M) potentiated substance P-induced cough; ...
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Characteristics of patients with neuropathic pain syndromes screened by the painDETECT questionnaire and diagnosed by physician exam
... There are several important limitations that should be con- sidered in interpreting the results of this paper. As with any patient-reported study, survey responses were subject to recall and self-reporting biases, which ...
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Optimizing data visualization for reproductive, maternal, newborn, child health, and nutrition (RMNCH&N) policymaking: data visualization preferences and interpretation capacity among decision-makers in Tanzania
... This study does not explore specific roles of individual civil servants in the decision-making process. In Tanzania, this role can vary based on institution and expertise. However, given that individual responsibilities ...
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Economic and humanistic burden of post-trauma and post-surgical neuropathic pain among adults in the United States
... PTPS NeP was defined as NeP following a known injury or surgical ...characteristic NeP qualities. As PTPS NeP patients presented for routine office visits, a trained physician or site ...
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Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase
... Although the bulk of the precursor remained intact after 20.5 h, the predominant processing product was a linear peptide lacking the C-terminal propeptide, demonstrating that correct N-t[r] ...
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Evaluation of Cotton Genotypes for Ginning Energy and Ginning Rate
... ton samples were stored for at least 3 d to equilibrate the moisture content before ginning. Seedcotton was weighed before ginning and the lint was weighed after ginning to determine the lint percent. Fuzz percent was ...
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EDUCATION AND DEMOGRAPHIC DIVIDEND – IN THE LIGHT OF DRAFT DOCUMENT OF NEP 2016
... Education is the most important element for the growth and prosperity of a nation. We are in the process of transforming itself into a developed nation by 2020.Youth plays a vital role in the formation of a country. The ...
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Qualitative Revision of the New Ecological Paradigm (NEP) Scale for children
... Another remarkable feature of such cross-cultural NEP scale studies is the in terpretation of the differences in ecological views found across nations. In Van Petegem and Blieck’s study, the authors found that ...
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