Neural stem cell
Age and sex differences in neural stem cell transplantation: a descriptive study in rats
... 2 neural stem cell (nSC) transplantation outcome in 20-month-old male ...red). Cell nuclei were visualized using the fluorophore 4′,6- diamidino- ...
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A Gene and Neural Stem Cell Therapy Platform Based on Neuronal Cell Type Inducible Gene Overexpression
... of neural stem cells introduced with a neuronal cell type–inducible luciferase overexpression system (NSE::Luci-NSCs) in normoxia and ...NSC, neural stem cell; NSE, ...
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Spatiotemporal evolution of early innate immune responses triggered by neural stem cell grafting
... of neural stem cell graft survival Histological analyses of brain tissue from cell-grafted mice were performed at day 0 (4 hours post-implanta- tion, n = 5), day 1 (n = 5), day 3 (n = 4), day ...
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Neural stem cell sex dimorphism in aromatase (CYP19) expression: a basis for differential neural fate
... Purpose: Neural stem cell (NSC) transplantation and pharmacologic activation of endogenous neurogenesis are two approaches that trigger a great deal of interest as brain repair ...using stem ...
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Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo
... NSC: neural stem cell; PCR: polymerase chain reaction; PET: positron-emission tomography; RNA: ribonucleic acid; SUV: standard uptake value; SVZ: subventricular zone; TuJ1: neuron-specific class III ...
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The Role of FoxJ1 in the Development and Regulation of the Adult Neural Stem Cell Niche
... adult neural stem cell niche (SCN) in the SVZ is thought to be required for perinatal neurogenesis and maintenance of adult neural stem cells, which produce layer-specific interneurons ...
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Neural stem cell-derived exosomes mediate viral entry
... detected in both the Coomassie staining and Western blot analysis may indicate posttranslational modification (eg, glycosylation). In addition, SDS–PAGE and Western blot analysis were performed with an exosome-specific ...
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Neural Stem Cell Biology in Vertebrates and Invertebrates: More Alike than Different?
... asymmetric cell division in some cell types, the nonrandom segregation of mother versus daughter centro- somes has been observed to correlate with differences in cell fate (reviewed by Macara and ...
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Cellular and Circuit Level Responses to Neural Stem Cell Transplantation in the Rodent Cortex
... Neural stem cell (NSC) transplantation is a promising strategy for the treatment of neurological disease and injury. NSC transplants have been documented to exert both neurotrophic and ...
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Expression of the Neural Stem Cell Markers NG2 and L1 in Human Angiomyolipoma: Are Angiomyolipomas Neoplasms of Stem Cells?
... Recently, stem cell precursors have been recognized that can give rise to smooth muscle and ...the neural stem cell marker NG2 and ...a cell line derived from a human ...
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Role of miR-146a in neural stem cell differentiation and neural lineage determination: relevance for neurodevelopmental disorders
... and cell type-specific manner. In primary mouse neural stem cell (NSC) cultured in EGF and FGF2, miR-146a overexpression promoted neuronal dif- ferentiation and cell cycle exit by ...
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Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobe
... two neural stem cell types: neuroepithelial cells, which divide symmetri- cally to expand the neural stem cell pool, and neuroblasts, which divide asymmetrically to self-renew ...
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Continuous live imaging of adult neural stem cell division and lineage progression in vitro
... of cell division. In order to assess whether a similar decrease in cell size can also be observed during lineage progression from stem cell to neuroblasts in vivo, cells from the adult SEZ ...
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Polycomb group genes are required for neural stem cell survival in postembryonic neurogenesis of Drosophila
... in neural proliferation come from studies of mammalian PcG genes, specifically of the Bmi1 gene (reviewed by Shakhova et ...cerebellar neural stem cells postnataly, indicating an in vivo requirement ...
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Neuronally expressed stem cell factor induces neural stem cell migration to areas of brain injury
... Our data are consistent with a previous report demonstrating that SCF expression is induced by brain injury in neurons sur- rounding the injury, as assessed by in situ hybridization and immunohistochemistry (61). ...
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Original Article Intracerebral neural stem cell transplantation improved the auditory of mice with presbycusis
... using the TUNEL-POD assay. The DAB method was performed to assess the apoptotic rate pre-transplantation in the AI in the young and aged groups. Only rare apoptotic cells (Figure 2E) were observed in young group, while ...
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The protein phosphatase activity of PTEN is essential for regulating neural stem cell differentiation
... The complete inactivation of PTEN can lead to sei- zures, highlighting its importance in normal brain function. The G129E mutation, observed in Cowden syndrome, specifically abolishes the lipid phosphatase activity [16], ...
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Pharmacologic modulation of nasal epithelium augments neural stem cell targeting of glioblastoma
... Glioblastoma (GBM) remains the most lethal and untreatable central nervous system malignancy. The challenges to devise novel and effective anti-tumor therapies include difficulty in locating the precise tumor border for ...
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Suppression of MicroRNA let 7a Expression by Agmatine Regulates Neural Stem Cell Differentiation
... that agmatine may enhance neurogenesis by negatively regu- Fig. 4. Assessment of c-Myc mRNA and ERK phosphorylation in neural stem cells. (A) c-Myc mRNA expression was reduced in the let-7a mimic treat- ...
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E-proteins orchestrate the progression of neural stem cell differentiation in the postnatal forebrain
... Our findings suggest that the effects of E-proteins on SVZ NSC differentiation are entirely dependent on Ascl1, which is expressed in all postnatal SVZ progenitors [19,56]. Knock-down of Ascl1 entirely abrogated the ...
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