Neural tube closure
MID1 and MID2 are required for Xenopus neural tube closure through the regulation of microtubule organization
... in neural tube ...the neural folds of unilaterally injected Mig12 morphants was reduced by the Mo-insensitive Mig12 mRNA (25, 50 ...on neural tube ...in neural tube ...the ...
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β catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation
... initiating neural tube closure and also for PNP ...during neural tube development (Sanchez-Ferras et ...PNP closure and elongation processes ...PNP closure and elongation ...
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Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development
... The identification of the unique interactomes of Fat1 and Fat4 could help explain the divergent roles of Fat1 and Fat4 but does not explain their common functions. In Drosophila, Fat forms cis-homodimers (Feng and ...
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RACK1 is a novel interaction partner of PTK7 that is required for neural tube closure
... in neural tube closure in the RACK1 and PTK7 morphants and the embryos remain shorter than the ...lateral neural plate marker) is expanded in stage 17-18 embryos injected with 10 ng RACK1 MO1 ...
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PREVALENCE OF NEURAL TUBE CLOSURE DEFECTS AND THE ORO FACIAL CLEFTS, DURING THREE CONSECUTIVE YEARS (2012 2014) IN 20 PUBLIC HOSPITALS IN MOROCCO
... Neural tube closure anomalies and oro-facial malformations are congenital malformations resulting respectively from neural tube defects (NTDs) of variable extent during the fourth week ...
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In toto live imaging of mouse morphogenesis and new insights into neural tube closure
... Fig. 1. A novel in toto imaging system for mouse embryogenesis. (A) Four drops of vacuum grease are added to a 24 ⫻ 24 mm coverslip (i). A black filter paper is attached by pressing the filter onto the vacuum grease ...
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Distinct intracellular Ca2+ dynamics regulate apical constriction and differentially contribute to neural tube closure
... of neural progenitor cells in a process called neural tube closure (NTC), and NTC failure causes a common human birth defect (Copp et ...the neural plate (NP) inward (Martin and ...
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Bone morphogenetic proteins regulate neural tube closure by interacting with the apicobasal polarity pathway
... During neural tube closure, specialized regions called hinge points (HPs) display dynamic and polarized cell behaviors necessary for converting the neural plate into a neural ...chick ...
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Identifying Regulators of Morphogenesis Common to Vertebrate Neural Tube Closure and Caenorhabditis elegans Gastrulation
... ABSTRACT Neural tube defects including spina bifida are common and severe congenital ...in neural tube ...vertebrate neural tube ...vertebrate neural tube ...
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Cdx mediates neural tube closure through transcriptional regulation of the planar cell polarity gene Ptk7
... PCP, which dictates the organization of cells within the plane of the epithelium, was first identified in Drosophila (Montcouquiol et al., 2006; Jones and Chen, 2007; Simons and Mlodzik, 2008) and is governed by a highly ...
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Neural tube closure: cellular, molecular and biomechanical mechanisms
... key neural tube closure regulatory ...in neural tube closure (NTC) are ...during neural fold (NF) fusion in the mouse spinal ...the neural plate (NP) is a ...
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MIM regulates vertebrate neural tube closure
... during neural tube closure, and disrupted Sonic hedgehog signaling can result in neural tube closure defects, whereas excessive signaling can abrogate the formation of paired ...
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The iron exporter ferroportin 1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure
... in neural tube closure are also due to iron deficiency remains to be ...humans, neural tube closure occurs during the third and fourth weeks of gestation, before many women are ...
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Multiple Sites of Anterior Neural Tube Closure in Humans: Evidence From Anterior Neural Tube Defects (Anencephaly)
... pothesis that humans, like other species, have multiple sites of anterior neural tube closure. Furthermore, the data provide evidence for two mechanisms leading to anterior neural tube d[r] ...
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Cell movements of the deep layer of non neural ectoderm underlie complete neural tube closure in Xenopus
... To prove that the dorsoanterior movement of the non-neural deep cells is the source of the tensile force on the superficial cells and that synchronized cell movements provide the force for complete NTC, we ...
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Actomyosin stiffens the vertebrate embryo during crucial stages of elongation and neural tube closure
... endoderm, neural and mesoderm, which is further subdivided into axial notochord, paraxial-medial somitic mesoderm and paraxial-lateral somitic ...contains neural ectoderm (ne), notochord (no), paraxial ...
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Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation
... Fig. 2. Zinc deficiency increases apoptosis during neural tube closure and in neuroepithelial cells. (A-C) Typical pictures from embryos grown in roller culture show that 10 µM TPEN treatment ...
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Folate deficiency induced H2A ubiquitination to lead to downregulated expression of genes involved in neural tube defects
... Neural tube closure requires cooperation of several mech- anisms, such as neural crest cell migration, proliferation, and differentiation. During neurogenesis, insufficient neu- ronal ...
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La-related protein 6 controls ciliated cell differentiation
... the neural plate to be critical for the process of the neural tube closure [25, ...the neural tube of LARP6 morphants were ...the neural tube of LARP6 mor- phants ...
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Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling
... The Mediator complex is commonly seen as a molecular bridge that connects DNA-bound transcription factors to the RNA polymerase II (Pol II) machinery. It is a large complex of 30 subunits that is present in all ...
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