Neuron death
Silencing of the Pink1 Gene Expression by Conditional RNAi Does Not Induce Dopaminergic Neuron Death in Mice
... Figure 3. Silencing of the PINK1 gene expression does not cause dopaminergic neuron death. (A) The striatal contents of the neurotrans- mitter dopamine (DA) and its me- tabolites DOPAC and HVA were measured ...
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Oligodendrocytes contribute to motor neuron death in ALS via SOD1 dependent mechanism
... before cell death was detectable. Electrophysiological recordings were performed at day 7 post MN seeding. This time point was chosen to allow MN maturation and at the same time to determine if MN distress could ...
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LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice
... This is, to our knowledge, the first study to investigate whether LRRK2 inhibition is able to reverse pathogenic α-synuclein-initiated pathology and neuron death in wildtype animals. Two other reports have ...
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Aldehyde Dehydrogenases 1A2 Expression and Distribution are Potentially Associated with Neuron Death in Spinal Cord of Tg(SOD1*G93A)1Gur Mice
... the neuron cell death in the Tg(SOD1*G93A)1Gur ...of neuron death in the spinal cord of ALS-like transgenic ...prevent neuron cells from the aldehydes ...the neuron regeneration ...
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Extracellular ATP and the P2X7receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis
... Non-transgenic astrocytes required multiple stimuli with ATP over several days to induce the neurotoxic phe- notype, while a single stimulus with the P2X 7 r-selective agonist BzATP was sufficient to activate astrocytes ...
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A combination Alzheimer’s therapy targeting BACE1 and neprilysin in 5XFAD transgenic mice
... Results: After crossbreeding between BACE1 heterozygous knockout (BACE1 +/ − ), neprilysin transgenic (NEP) and 5XFAD mice, we analyzed the resultant mice at 12 months of age when 5XFAD controls showed robust amyloid- β ...
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Emerging mechanisms of molecular pathology in ALS
... Prion-like domains in ALS proteins. ALS usually begins focally and spreads in a pattern that implicates contiguous pools of motor neurons. The possibility that a pattern of dissemination of pathol- ogy and then motor ...
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Original Article Acupuncture at ST36 improves survival and ameliorates motor neuron defects by the activation of autophagy
... motor neuron disorders associated with muscle wast- ing are regarded as Atrophy ...motor neuron disorders after stroke ...motor neuron death via engage- ment of endogenous immune modulatory ...
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Nasal neuron PET imaging quantifies neuron generation and degeneration
... dynamic neuron popu- lation whose total neuron count is continuously dependent on the balance of neuron generation and neuron death, processes that Olfactory dysfunction is broadly ...
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Innate immunity in the Grid2Lc/+ mouse model of cerebellar neurodegeneration: glial CD95/CD95L plays a non-apoptotic role in persistent neuron loss-associated inflammatory reactions in the cerebellum
... the death receptor CD95 has a wider role in non-apoptotic ...neural death and to the associated inflammatory reaction via a non-apoptotic ...activation, neuron death and CD95/CD95L expression ...
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Soybean-derived Bowman-Birk inhibitor inhibits neurotoxicity of LPS-activated macrophages
... neuron death. Although LPS, when directly added to the rat cortical neuron cultures, had no cytotoxic effect (Figure 1A), supernatant from LPS-activated macrophage cultures induced the neuron ...
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The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection
... DA neuron survival, these findings raised the possibility that CDDO-Me may be able to protect neuronal populations that display increased vulnerability to inflammation-induced oxidative stress and apoptotic ...
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The Effects of Minocycline on Spinal Root Avulsion Injury in Rat Model
... A dorsal midline incision was made at the neck. Subcutaneous dissection was performed at the skin incision site for placement of a microinfusion pump. C6/7 hemilaminectomy was performed using a microrounger. An ...
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Timing control of single neuron spikes with optogenetic stimulation
... cortical neuron whose behavior follows the Izhikevich neuron ...Izhikevich neuron model provides an efficient and biologically plausible method to track a cortical neuron’s membrane potential and its ...
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Human prion protein-induced autophagy flux governs neuron cell damage in primary neuron cells
... primary neuron cell death and decreased both LC3-II and p62 protein amount indicating autophagy flux ...in neuron cells treated with prion ...prevented neuron cell death induced by ...
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Dual modulation on glial cells by tetrahydroxystilbene glucoside protects against dopamine neuronal loss
... midbrain neuron-glia cultures were treated with TSG (20 – 80 μ M) for 30 min before LPS (10 ng/ml) ...midbrain neuron-glia cultures were treated with TSG (20 – 80 μ M) for 30 min and then stimulated by LPS ...
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Characterization of a descending pathway: activation and effects on motor patterns in the brachyuran crustacean stomatogastric nervous system
... In in vivo experiments the activities of the dorsal ventral nerve (dvn) and the ivn were recorded extracellularly. For identification of the IV neuron spikes, we determined the conduction direction of spikes on ...
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Neurons of self-defence: neuronal innervation of the exocrine defence glands in stick insects
... SOG neuron projecting into the ...stained neuron somata that do not actually innervate the gland would be neurosecretory or peptidergic cells with release sites in the periphery [53, 54] and with extensions ...
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Sensory induced modification of two motor patterns in the crab, Cancer pagurus
... The impact of AGR on the pyloric rhythm has not been previously described. Our results show that AGR diminished the spike activities of two pyloric neurons, IC and VD. Both are follower neurons and do not directly ...
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Pivotal Role of Receptor-Interacting Protein Kinase 1 and Mixed Lineage Kinase Domain-Like in Neuronal Cell Death Induced by the Human Neuroinvasive Coronavirus OC43
... caspase-8-dependent apoptosis is inhibited or altered or when endogenous RIP3 expression is high enough to sensitize cells to necroptosis activation (73). Moreover, many neurological disorders, such as amyotrophic ...
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