Neuronal Apoptosis
The role of microglia and the TLR4 pathway in neuronal apoptosis and vasospasm after subarachnoid hemorrhage
... that neuronal apoptosis seen in WT SAH and TRIF−/− SAH was significantly greater than that seen in LPS on POD 7, despite equivalent de- grees of vasospasm (Figure ...between neuronal apop- tosis and ...
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Mechanisms of ATF4-mediated neuronal apoptosis
... We have previously indicated that a transcriptional activator other than p53 is required for Puma induction during ER-stress (Appendix B Figure 2). The transcription factor ATF4 has been implicated in ER-stress, however ...
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Acute upregulation of neuronal mitochondrial type-1 cannabinoid receptor and it’s role in metabolic defects and neuronal apoptosis after TBI
... As mitochondrial cAMP/PKA/complex I pathway has been found to be the downstream target of mtCB1 and is involved in mtCB1 mediated aerobic metabolism of normal neurons [7]. We tested the possible effects of mitochondrial ...
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<p>Conditioned taste aversion memory extinction temporally induces insular cortical BDNF release and inhibits neuronal apoptosis</p>
... including cell proliferation, differentiation, death, and survi- val. Moreover, it improves impaired learning and memory in patients with Alzheimer ’ s disease by inducing the survival mechanisms. 39 In addition, p-Erk ...
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Rapamycin inhibits Erk1/2-mediated neuronal apoptosis caused by cadmium
... Cd-induced neuronal apoptosis, Erk1/2 was silenced by RNA ...Cd-induced apoptosis in PC12 cells as well (Figure ...Cd-induced apoptosis in PC12 cells, SH-SY5Y cells and primary ...
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Activated brain mast cells contribute to postoperative cognitive dysfunction by evoking microglia activation and neuronal apoptosis
... and neuronal death and exhibited cognitive ...activation, neuronal death, and improved cognitive function 24 h after the ...induce neuronal apoptosis and synapse injury with microglia ...
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Gadd45b is a Novel Mediator of Neuronal Apoptosis in Ischemic Stroke
... of neuronal apoptosis in models of ischemic brain injury seems ...reperfusion. Apoptosis-related molecules were studied using immunohistochemistry and Western blot analy- ...increased neuronal ...
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Investigation of the role of cyclin dependent kinases in neuronal apoptosis
... and neuronal PCI2 cells in response to DNA damage or NGF withdrawal, and overexpression of these proteins causes neuronal apoptosis (Liu and Greene, ...during apoptosis of smooth muscle cells ...
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Activated microglia contribute to neuronal apoptosis in Toxoplasmic encephalitis
... inhibit apoptosis of infected cells to ensure better dissemination within the host [4] and their own intracellular survival ...induced apoptosis of bystander cells by se- cretion of some soluble factors ...
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An investigation of the regulation and role of c-Jun during neuronal apoptosis
... by apoptosis, along with the processes of proliferation and differentiation, is of crucial importance during the life of all vertebrates and ...induce apoptosis in the presence of cycloheximide (which ...
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ATP Controls Neuronal Apoptosis Triggered by Microtubule Breakdown or Potassium Deprivation
... Cell death was triggered in cere- bellar granule neurons (CGC) by the cytoskeletal disrupting agents colchicine or nocodazole, which are known to trigger caspase activation (18) and dela[r] ...
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Identification of neuronal caspases and involvement of death domain proteins in neuronal apoptosis
... by apoptosis is clearly defined by its typical morphological features, remarkably similar in all cell types, and occurs both in physiological development and in pathological states (Wyllie et ...induce ...
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Original Article Icariin protects against cerebral ischemia/reperfusion injury by activating the PI3K/Akt signaling pathway
... Abstract: Icariin has been proved to confer neuroprotection against cerebral ischemia/reperfusion (I/R) injury. However, the exact mechanisms remain unclear. We therefore investigated the neuroprotective role of icariin ...
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TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targets
... lysosomal cysteine proteases that play key roles in various cellular functions, including synaptic plasticity and neuronal apoptosis. To achieve its functions, calpain acts on different substrates, ...
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Original Article HIF1α and HIF2α mediated UCHL1 upregulation in hypoxia-induced neuronal injury following neuronal hypoxic ischemic encephalopathy
... To further investigate the reasons for upregu- lated UCHL1 expression in neonatal HIE, UCHL1 expression was also analyzed under hypoxia- induced neuronal apoptosis, simulating neona- tal HIE in vitro. ...
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Apoptosis in Neurodegeneration: Programmed Cell Death and its Role in Alzheimer’s and Huntington’s Diseases
... mitochondrial apoptosis, may also be involved in the death-receptor ...of neuronal cell membrane receptors to promote this apoptotic pathway (Figure 2; Yuan and Yanker ...promote neuronal ...
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... The clinical picture of dementia as a deteriorate in cognition in the past years has been recognized for centuries but understood in its current form only from past 20 years. Alzheimer’s disease (AD) is the most common ...
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Sinomenine reduces neuronal cell apoptosis in mice after traumatic brain injury via its effect on mitochondrial pathway
... The protective effects of SIN against neuronal apoptosis after TBI were also detected by Western blot analysis and immunohistochemistry of mouse brain tissues. The number of caspase-3-positive cells in the ...
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Hyperglycaemia and apoptosis of microglial cells in human septic shock
... with neuronal ischaemia, microglial activation and apoptosis as well as neuronal apoptosis, which was statistically correlated with endothelial expression of iNOS ...with neuronal or ...
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Expression of the human PAC1 receptor leads to dose dependent hydrocephalus related abnormalities in mice
... (SCO). Neuronal proliferation and apoptosis were implicated in hydrocephalus, and we observed significantly reduced neuronal proliferation and massively increased neuronal apoptosis in ...
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