Neuronal Death
miR-212-5p attenuates ferroptotic neuronal death after traumatic brain injury by targeting Ptgs2
... cell death, has been implicated in traumatic brain injury ...ferroptotic neuronal death in TBI mice, we first examined the accumulation of malondialdehyde (MDA) and ferrous ion, and the expression of ...
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Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease
... and neuronal versus glial cell ...on neuronal death and ...and neuronal numbers are largely ...age-dependent neuronal loss without degrading the retinal ...cell death, and ...
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A neuronal death model: overexpression of neuronal intermediate filament protein peripherin in PC12 cells
... of neuronal IF aggregates in the diseases are still ...disorders. Neuronal IF aggregates were seen in the early stages (d0-d2) of differentiation of pEGFP-Peripherin cells, while neuronal ...
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Prevention of hypoglycemia-induced neuronal death by minocycline
... hypoglycemia-induced neuronal death and cognitive ...for neuronal death and microglial activation was performed from 1 day to 1 week after ...immunoreactivity. Neuronal death was ...
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Deciphering the molecular signaling cascade in neuronal death
... that neuronal death is dependent on both MPT and redistribution of CYTC and AIF triggered by both caspase-3 and calpain activation (Ferrand-Drake et ...cell death (Polster et al., 2005). As such, ...
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Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase
... Zinc chelation prevents superoxide production during GR. The mechanism by which NADPH oxidase is activated in nonphago- cytic cells such as neurons is not well understood, but zinc has been identified as both an inducer ...
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N Methyl d Aspartate (NMDA) Receptor Blockade Prevents Neuronal Death Induced by Zika Virus Infection
... ZIKV-induced neuronal cell ...and neuronal cells and characterization of neuronal cell death after ...E) Neuronal death was assessed using the LIVE/DEAD assay in primary neurons ...
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Interferon-γ increases neuronal death in response to amyloid-β1-42
... In AD, amyloid deposits containing fibrillar amyloid-β peptides frequently co-localise with inflammatory cells strongly suggesting that the deposits of amyloid-β stimu- late a chronic inflammatory process [6]. Genetic ...
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Inflammation and neuronal death in the motor cortex of the wobbler mouse, an ALS animal model
... to neuronal degeneration ...acute neuronal degeneration and death [21] and also in chronic neurodegenerative dis- eases such as Alzheimer and Parkinson diseases ...cause neuronal stress and ...
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DHCR24 exerts neuroprotection upon inflammation-induced neuronal death
... well-established neuronal survival pathways regulated by Akt, ERK1/2, or ...improved neuronal survival upon neuroinflammation does not associate with significantly increased total cholesterol levels, but ...
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Landshamer, Stefan (2007): Role of Bid and AIF in Glutamate-induced Neuronal Cell Death. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... cell death through caspase-independent mechanisms through its serine protease activity [39, ...to death around 30 days after birth ...ischemic neuronal death ...cell death after ...
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Early Hippocampal Synaptic Loss Precedes Neuronal Loss and Associates with Early Behavioural Deficits in Three Distinct Strains of Prion Disease
... Prion diseases are fatal neurodegenerative diseases of the CNS that are associated with the accumulation of misfolded cellular prion protein. There are several different strains of prion disease defined by different ...
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Ubiquitin proteasome system dysfunction in experimental models of Parkinson's disease
... the nigral sections indicated that the percentage loss of nuclei (Figure 5B and D) was less profound compared to that in TH neurons (Fig. 5B and C) indicating enhanced vulnerability of dopaminergic neurons to proteasomal ...
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Histopathologic Correlates of Temporal Diffusion Changes in a Rat Model of Cerebral Hypoxia/Ischemia
... selective neuronal death, whereas the biphasic and persistent patterns were associated with cerebral infarction that finally showed high signal intensity on T2-weighted im- ...
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Disruption of the nuclear p53-GAPDH complex protects against ischemia-induced neuronal damage
... glutamate-induced neuronal excitotoxicity, while accumulated evidence also demonstrated that GAPDH nuclear translocation plays a critical role in cell ...cell death and GAPDH-mediated up-regulation of p53 ...
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Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia
... Studies were performed in accordance with the Declaration of Helsinki and with the Guide for the Care and Use of Laboratory Animals as adopted and promulgated by National Institutes of Health (Bethesda, MD, USA). Our ...
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The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease
... massive neuronal loss, such as mutant tau models of FTDP-17 ...if neuronal death is mediated by a linear cascade, the likelihood that a therapeutic agent targeting any one of the insults within that ...
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The Role of Zinc in Cerebral Ischemia
... neural-specific target genes, including GluR2 (22,23). Calderone and colleagues (22) further demonstrated that during is- chemia, zinc triggers neuronal death through temporally distinct mechanisms. It was ...
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The Effects of Local Fetal Brain Extract Administration on the Electromyogram of Crushed Sciatic Nerve in Rat
... cell death following peripheral nerve injury are currently unknown, a major contributing factor is likely to be deprivation of target-derived neurotrophic factors such as the neurotrophins ...[18]. Neuronal ...
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Neuronal Cell Death and Mice (Mus Musculus) Behaviour after Induced by Bee Venom
... Abstract: Neuronal cell death can occur in a tissue or organ, including the brain, which affects ...causes neuronal death and analyse the alteration of mouse behaviour, focusing in particular ...
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