neuropilin 2
Direct transcriptional regulation of neuropilin 2 by COUP TFII modulates multiple steps in murine lymphatic vessel development
... The lymphatic system plays a key role in tissue fluid homeostasis. Lymphatic dysfunction contributes to the pathogenesis of many human diseases, including lymphedema and tumor metastasis. However, the mecha- nisms ...
15
miR-486-5p attenuates tumor growth and lymphangiogenesis by targeting neuropilin-2 in colorectal carcinoma
... that neuropilin-2 was a direct functional target of miR-486-5p in the CRC cells, and upregulation of miR-486-5p in CRC cells negatively correlated with the expression of ...
7
Deficiency of Neuropilin 2 Suppresses VEGF-Induced Retinal Neovascularization
... role. Neuropilin-1 (Npn1) and neuropilin-2 (Npn2) were 1st identified as receptors for semaphorins, a family of extracellular proteins that function in axon guidance ...
7
Original Article MiR-486-5p inhibits metastasis by targeting neuropilin-2 in gastric cancer
... Abstract: Previous studies have revealed that aberrant expressions of miRNAs participate in almost every step of carcinogenesis. Despite of large numbers of miRNAs disclosed, the function of miR-486-5p in the metastasis ...
7
Elevated expression of neuropilin-2 associated with unfavorable prognosis in hepatocellular carcinoma
... Abstract: Neuropilin-2 (NRP2) is a single-pass transmembrane glycoprotein and has recently been detected in several human cancer cells. However, its clinical relevance in hepatocellular carcinoma (HCC) ...
7
Deletion of neuropilin 2 enhances detrusor contractility following bladder outlet obstruction
... In a recent study, we reported a novel role for neuropilin 2 (Nrp2) as a regulator of SM contractility (14). Nrp2 is a transmembrane receptor that binds VEGF family members and class 3 semaphorins (SEMA3) ...
11
Guidance of trunk neural crest migration requires neuropilin 2/semaphorin 3F signaling
... Aminopropyltriethoxysilane (2%; APTES; Sigma) was prepared in 95% ethanol and allowed to hydrolyze for 5 minutes in a fume hood. Thermanox (25 mm; Nunc) cover slips in a wafer basket (Fluoroware) were incubated in ...
8
Axonal wiring of guanylate cyclase D expressing olfactory neurons is dependent on neuropilin 2 and semaphorin 3F
... For immunohistochemistry, mice were deeply anaesthetized and intracardially perfused with 4% paraformaldehyde (pH 7.4), postfixed on ice for 3 hours and finally sunk in 30% sucrose overnight. They were then frozen in OCT ...
10
Neuropilin 2 promotes branching morphogenesis in the mouse mammary gland
... Fig. 2. Loss of NRP2 impedes branching morphogenesis and invasion of epithelial cells into the mammary fat pad. (A) Schematic of method for quantification of mouse mammary gland development. Each whole-mounted ...
8
The wiring of Grueneberg ganglion axons is dependent on neuropilin 1
... of neuropilin 2 alters the projection map formed by GC-D-expressing neurons in the necklace glomeruli in mice (Walz et ...bulb. Neuropilin 2 plays thus a role in preventing GC-D axons from ...
9
Neuropilin receptors guide distinct phases of sensory and motor neuronal segmentation
... The segmented trunk peripheral nervous system is generated by ventrally migrating neural crest cells that exclusively invade the anterior sclerotome and differentiate into metameric dorsal root and sympathetic ganglia. ...
10
The emerging role of class-3 semaphorins and their neuropilin receptors in oncology
... or neuropilin ligands, such as veGF, to increase invasion and metastatic ...NRP, neuropilin; PDGF, platelet-derived growth factor; PDGFR, PDGF receptor; PlGF, placental growth factor; SAP, stress-activated ...
25
COUP TFII controls amygdala patterning by regulating neuropilin expression
... The mammalian amygdala, a complex located in the caudoventral telencephalon, comprises 11-15 nuclei, which are anatomically, genetically and functionally distinct. The amygdala plays a central role in modulating emotion ...
10
Neuropilin asymmetry mediates a left right difference in habenular connectivity
... encoding Neuropilin receptors and their Semaphorin binding partners was re-evaluated because of their known role in FR formation in the mouse (Chen et ...as 2 days ...
9
Potentiating angiogenesis arrest in vivo via laser irradiation of peptide functionalised gold nanoparticles
... and metalloproteinase 9 (MMP-9), when compared to the scramble peptide alone or conjugated to AuNPs—Fig. 5. MMP-9 is a matrix metalloproteinase involved in the breakdown of extracellular matrix, and facilitates the vas- ...
8
Prognostic implication of neuropilin-1 upregulation in human nasopharyngeal carcinoma
... Following a hematoxylin counterstaining, immunostain- ing was scored by two independent observers, who were blinded to the clinicopathological parameters and clinical outcomes of the patients. The scores of the two ...
6
Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders
... of neuropilin 1 in young ASD individuals compared to ...The neuropilin protein family has been implicated in the em- bryonic development of neural and vascular systems, and regulation of many processes in ...
9
Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart
... before careful addition of DMEM supplemented with 0.5% fetal bovine serum (FBS), Normocin™ (invivoGen) and penicillin/streptomycin antibiotics (Sigma-Aldrich) into the wells or slide chambers. Medium was changed every ...
59
Neuropilin 1 upregulation elicits adaptive resistance to oncogene targeted therapies
... Precision oncology relies on treating individual tumors with drugs that target their specific vulnerabilities. Cancer cells are often characterized by the constitutive activation of an oncogenic sig- naling cascade to ...
16
<p>Long noncoding RNA SNHG16 silencing inhibits the aggressiveness of gastric cancer via upregulation of microRNA-628-3p and consequent decrease of NRP1</p>
... Agomir-628 – transfected or agomir-NC – transfected cells in the logarithmic growth phase were collected and injected subcutaneously into female 4 – 6-week-old BALB/c nude mice (n=4 for each group; the Laboratory Animal ...
15