Neutralizing monoclonal antibodies
Poliovirus neutralization epitopes: analysis and localization with neutralizing monoclonal antibodies.
... 3 0022-538X/82/090997-09S02.00/0 Copyright 0 1982, American Society for Microbiology Poliovirus Neutralization Epitopes: Analysis and Localization with Neutralizing Monoclonal Antibodies[r] ...
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Inhibition of rhinovirus attachment by neutralizing monoclonal antibodies and their Fab fragments.
... The importance of studying several neutralizing monoclonal antibodies became apparent when we found that antibody binding to NImIB, NImIl, and NImlll sites resulted in the polymerization[r] ...
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Neutralizing monoclonal antibodies to human rotavirus and indications of antigenic drift among strains from neonates.
... The instability 5 and inefficient production 25 of intact human rotavirus particles in cell culture may contribute to the low numbers of neutralizing monoclonal antibodies we derived to [r] ...
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Neutralizing and non neutralizing monoclonal antibodies against dengue virus E protein derived from a naturally infected patient
... purified antibodies and purified DENV E proteins were performed using biolayer interferometry with an Octet QK system (Forte- bio, Menlo Park, ...to antibodies at several different concentrations, and ...
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Neutralizing monoclonal antibodies to Theiler's murine encephalomyelitis viruses.
... DATC virion capsid proteins A, partially purified DAMB virion capsid proteins B to F, or a crude DAMB brain homogenate G to K were run on SDS-PAGE, blotted to nitrocellulose paper, and o[r] ...
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Isolation and characterization of neutralizing monoclonal antibodies to vaccinia virus.
... Based on the binding of mAbs to V-8 protease cleavage products of the 14K protein, the extent of protein recognition for other poxviruses, and differences in the degree of virus neutrali[r] ...
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Respiratory Syncytial Virus-Neutralizing Monoclonal Antibodies Motavizumab and Palivizumab Inhibit Fusion
... RSV F protein mediated cell-to-cell fusion is inhibited by palivizumab and motavizumab. In order to better assess the process of fusion by F protein, a quantitative assay to measure F protein mediated cell-to-cell fusion ...
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Neutralizing monoclonal antibodies against human immunodeficiency virus type 2 gp120.
... isolate-specific neutralizing activity in both cell-to-cell infection and cell-free-infection with HIV-1 (28, 32, ...reactive neutralizing antibody could also be induced against the con- served tip sequence ...
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Neutralizing monoclonal antibodies against three serotypes of porcine rotavirus.
... Neutralization titers of MAbs with SA-11 rotavirus mutants, reassortants, and porcine rotaviruses Titer of MAb" Rotavirus" strain... 3549 zation of rotavirus infectivity.[r] ...
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Neutralizing monoclonal antibodies to hepatitis A virus: partial localization of a neutralizing antigenic site.
... The monoclonal antibodies used in cross-linking experiments, immune precipitations of labeled HAV, and other experiments to identify the neutralizing sites on the virus were purified fro[r] ...
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Antibody-selected variation and reversion in Sindbis virus neutralization epitopes.
... Multisite variants, including one altered in three neutralization sites, were obtained by selecting mutants consecutively in the presence of different neutralizing monoclonal antibodies.[r] ...
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Isolation and Characterization of Monoclonal Antibodies Which Neutralize Human Metapneumovirus In Vitro and In Vivo
... single monoclonal antibody directed at the fusion (F) protein can prevent severe lower respiratory tract RSV ...neutralizing antibodies. Here we describe the generation of a panel of ...
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Structure of Respiratory Syncytial Virus Fusion Glycoprotein in the Postfusion Conformation Reveals Preservation of Neutralizing Epitopes
... process. Neutralizing monoclonal antibodies, such as 101F, palivizumab, and motavizumab, target two major antigenic sites on the RSV F ...Both antibodies bound the postfusion F glycoprotein ...
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Neutralization epitopes of the F glycoprotein of respiratory syncytial virus: effect of mutation upon fusion function.
... * 2941 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Eighteen neutralizing monoclonal antibodies MAbs specific for the fusion glycoprotein of the A2 strain of respira[r] ...
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Poorly Neutralizing Cross-Reactive Antibodies against the Fusion Loop of West Nile Virus Envelope Protein Protect In Vivo via Fcγ Receptor and Complement-Dependent Effector Mechanisms
... Although antibodies against this epitope fail to recognize fully mature West Nile virus (WNV) virions and accordingly neutralize infection poorly in vitro, their functional properties in vivo remain less well ...
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Characterization of Structural Features and Diversity of Variable-Region Determinants of Related Quaternary Epitopes Recognized by Human and Rhesus Macaque Monoclonal Antibodies Possessing Unusually Potent Neutralizing Activities
... potently neutralizing monoclonal antibodies (MAbs) that target quaternary epitopes on the native Env trimer have recently been ...these antibodies is the critical involve- ment of sites in ...
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REVIEW ON EBOLA VIRUS
... three neutralizing monoclonal antibodies (mAbs) directed against the Ebola envelope glycoprotein (GP) resulted in complete survival (four of four cynomolgus macaques) with no apparent side effects ...
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Isolation and Characterization of Human Monoclonal Antibodies from Individuals Infected with West Nile Virus
... with neutralizing and/or CF activity that varied over a 2-log-unit concentration range; however, the majority exhibited activity only at higher concentrations (see Table S1 in the supplemental ...
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Lung endothelial monocyte activating protein 2 is a mediator of cigarette smoke–induced emphysema in mice
... EMAPII is known to be produced in response to oxidative or hypoxic stresses and through proteolytic cleavage from intracellular tRNA synthetase. Therefore, CS could upregulate EMAPII directly via oxidative stress or by ...
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PIIS2352396419301392.pdf
... 92 antibodies were recombinantly expressed as IgG1, they were derived from native antibodies that were either IgG1 (83/92, 90%), IgG2 (3/92, 3%), or IgG3 isotypes (6/92, ...expressed antibodies bound ...
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