Neutrophilic inflammation
Sputum colour can identify patients with neutrophilic inflammation in asthma
... airway inflammation (total cell number, neutrophil number and proportion and CXCL-8) using Bronko- Test sputum colour ...with neutrophilic inflammation and could predict the pres- ence of ...
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Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
... The regulation of neutrophil lifespan by induction of apoptosis is critical for maintaining an effective host response and preventing excessive inflammation. The hypoxia-inducible factor (HIF) oxygen-sensing ...
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Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist
... predominantly neutrophilic pat- tern of inflammation, which is relatively resistant to the anti-inflammatory effects of corticosteroids, making them difficult to manage in clinical ...target ...
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Distribution of sputum cellular phenotype in a large asthma cohort: predicting factors for eosinophilic vs neutrophilic inflammation
... and neutrophilic inflammation ...20% neutrophilic asthma, 31% paucigranulocytic asthma and 8% mixed granulocytic asthma ...and neutrophilic asthma and the higher proportion of ...
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Anti-TNF inhibits the Airways neutrophilic inflammation induced by inhaled endotoxin in human
... with neutrophilic asthma ...airways’ neutrophilic inflammation, future studies could investigate what kind of patient can benefit from anti-TNF, in regard to their inflam- matory sensitivity to ...
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CXCL5 secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis
... myeloid cells, such as macrophages and PMNs (31), and their importance in PMN recruitment to inflamed lungs is well appre- ciated in various infectious diseases (30, 32–36). CXCL15, which is produced by bronchial ...
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Phospholipase Cε plays a crucial role in neutrophilic inflammation accompanying acute lung injury through augmentation of CXC chemokine production from alveolar epithelial cells
... As neutrophils are known to play a crucial role in ALI, we examined the nature of the leukocytes infiltrated into the lungs by analyzing BALF collected in 24 h after the LPS administration. Differential leukocyte ...
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Activation of Src-dependent Smad3 signaling mediates the neutrophilic inflammation and oxidative stress in hyperoxia-augmented ventilator-induced lung injury
... In addition to playing a role in TGF-β1-mediated lung fibrogenesis, Smad3, a cytoplasmic signal transducer pro- tein, was proven to be involved in the pathogenesis of ALI [3, 13, 19, 25]. Activation of Smad-2/3 signaling ...
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Genetic Regulation of Zfp30, CXCL1, and Neutrophilic Inflammation in Murine Lung
... We adopted this expression-centric view in an effort to identify new candidate genes for experimental asthma, which is composed of multiple phenotypes including granulocytic (eosinophilic and neutrophilic) ...
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Enterovirus D68 infection induces IL-17–dependent neutrophilic airway inflammation and hyperresponsiveness
... airway inflammation, expression of cytokines (TNF-a, IL-6, IL-12b, IL-17A, CXCL1, CXCL2, CXCL10, and CCL2), and airway hyperresponsiveness, which were suppressed by anti–IL-17A ...antibody. Neutrophilic ...
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The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease
... of neutrophilic inflammation ...PGP-mediated inflammation is ...acute neutrophilic inflammation by a novel extracellular aminopeptidase activity of the enzyme leukotriene A 4 hydrolase ...
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Pharmacologic inhibition of MEK1/2 reduces lung inflammation without impairing bacterial clearance in experimental Pseudomonas aeruginosa pneumonia
... of inflammation during an experimental model of ...alveolar neutrophilic inflammation and led to faster recovery of weight, which we interpreted as bene- ficial ...
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TNF is required for TLR ligand–mediated but not protease mediated allergic airway inflammation
... Dissection of the TLR ligand model into the sensitization and challenge phases revealed that TNF affects eosinophilic and neutrophilic inflammation in different ways (Supplemental Fig- ure 11). The reduced ...
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Reduction of neutrophilic lung inflammation by inhalation of the compatible solute ectoine: a randomized trial with elderly individuals
... The current randomized double-blinded crossover trial dem- onstrated that daily inhalation of ectoine had beneficial effects on inflammatory sputum parameters in elderly volunteers. A significant reduction of nitrogen ...
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Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice
... Interestingly, the role of LXR in the regulation of neutrophilic inflammation appears to be dependent on the type of pathogen. Thus, Smoak et al. showed that LXR activation impaired, rather than promoted, ...
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Targeting IL-17A/glucocorticoid synergy to CSF3 expression in neutrophilic airway diseases
... persistent neutrophilic airway inflammation, increased collagen deposition, and upregulated expression of inflammatory (Il17, Csf3, Cxcl1, and Cxcl2) and remodeling genes (Tgfb1, Muc5b, Col1a1, and Acta2), ...
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Virus-triggered exacerbation in allergic asthmatic children: neutrophilic airway inflammation and alteration of virus sensors characterize a subgroup of patients
... Airway inflammation in infected patients was characterized by significantly higher IL-5 concentration and eosinophil ...airway neutrophilic inflammation at steady ...
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Cellular mechanisms underlying steroid-resistant asthma
... by inflammation of the airways and a clinical history of wheezing, cough, tightness of chest and shortness of breath varying with time and intensity, as well as expiratory airflow limitation ...eosinophilic ...
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Neutrophilic proteolysis in the cystic fibrosis lung correlates with a pathogenic microbiome
... The finding that microbial diversity and metabolite di- versity have a negative relationship was an intriguing phenomenon that has been previously reported in sputum in a smaller study [11]. It would normally be expected ...
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In young children, persistent wheezing is associated with bronchial bacterial infection: a retrospective analysis
... Results: 33 children aged between 4 and 38 months, without structural anomalies of the conductive airways were evaluated. Significant bacterial BAL cultures were found in 48,5 % of patients. Haemophilus influenzae was ...
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