NF-kappa B
In vivo suppression of NF kappa B and preservation of I kappa B alpha by interleukin 10 and interleukin 13
... factor kappa B (NF-kappa B). Activation of NF-kappa B involves the degradation of its cytoplasmic inhibitor I kappa B alpha, allowing the nuclear ...
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Eggshell membrane hydrolyzates activate NF-κB in vitro: possible implications for in vivo efficacy
... to NF- κ B activity determination. ESM-FH NF- κ B activity was compared with untreated cells and cells treated with the fermentation broth (minus ...vitro NF- κ B activity of ESM ...
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Apoptosis and the FLIP and NF-kappa B proteins as pharmacodynamic criteria for biosimilar TNF-alpha antagonists
... and NF-κB as new criteria for analyzing the pharmacodynamics of possible biosimilar TNF-α antagonists which should be submitted to regulatory agencies for ...
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Control of axis formation in Xenopus by the NF kappa B I kappa B system
... Int J !)e" l\iol 39 5 19 558 (1995) 549 Original Article Control of axis formation in Xenopus by the NF KB h(Bsystem DAVID TANNAHill" and FIONA C WARDLE' Department of Anatomy, University of Cambridge[.] ...
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TL1-A can engage death receptor-3 and activate NF-kappa B in endothelial cells
... of NF-κB (NF-κBp65). No NF-κB activation was detected in untreated normal kidney cultures either in glomerular EC or interstitial ...for NF-κBp65 indicative of NF-κB activation (Figure ...
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The regulation of constitutive NF-[kappa]B activity by glycogen synthase kinase-3 in pancreatic cancer
... constitutive NF-κB reporter activity and expression of NF-κB target genes in pancreatic cancer cells (Ougolkov, Fernandez-Zapico et ...constitutive NF-κB activity in Panc-1 and MiaPaCa-2 ...
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The kappa B enhancer motifs in human immunodeficiency virus type 1 and simian virus 40 recognize different binding activities in human Jurkat and H9 T cells: evidence for NF-kappa B-independent activation of the kappa B motif.
... Unlike Jurkat cells in which there is little KB motif-binding activity in the absence of treatment with PMA and PHA compare lanes 1 and 3, uninduced H9 cells already display five KB moti[r] ...
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Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C.
... addition, TPA did not further stimulate CAT activity in cells cotransfected with pwtX and pKB-CAT data not shown, demonstrating the efficient activation of sequestered NF-KB by X protein[r] ...
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Rhein attenuates inflammation through inhibition of NF-κB and NALP3 inflammasome in vivo and in vitro
... Abstract: Rhein is an important component in traditional Chinese herbal medicine formulations for gastrointestinal disorders, including inflammatory bowel diseases such as ulcerative colitis. In this study, we ...
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Hepatitis B virus pX activates NF-kappa B-dependent transcription through a Raf-independent pathway.
... of NF- k B by pX does not require Ras or ...k B-CAT (35), pSV-X (34), and vectors encoding either a dominant negative Ras mutant (pSV-Ras N17) (47) or a dominant negative Raf-1 mutant (pRSV-RafC4) ...
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Persistent activation of NF-kappa B/Rel by human T-cell leukemia virus type 1 tax involves degradation of I kappa B beta.
... k B b is strikingly low in HTLV-1-in- fected ...k B a undergoes degradation and resynthesis in HTLV-1-infected T cells (29, ...k B a may contribute to the constitutive nuclear expression of ...
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Papaverine inhibits lipopolysaccharide-induced microglial activation by suppressing NF-κB signaling pathway
... antibodies, NF- k B P65 (C22B4) rabbit mAb (1:1,000; #4764, Cell Signal- ing, Danvers, MA, USA), Phospho-IKK α / β (Ser176/180) (16A6) rabbit mAb (1:1,000; #2697, Cell Signaling), β -actin (1:500; #ab3280, ...
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Inflammation, cytokines, the IL-17/IL-6/STAT3/NF-κB axis, and tumorigenesis
... MMP-2, B-cell lymphoma, and cyclin D 1 , decreased expression of Bcl-2-associated X protein, and increased expression of vascular endothelial growth factor (VEGF) and VEGF receptor expression that were associated ...
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Tax induces nuclear translocation of NF-kappa B through dissociation of cytoplasmic complexes containing p105 or p100 but does not induce degradation of I kappa B alpha/MAD3.
... Tax protein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor KB and induces nuclear translocation of transcription factor NF-KB proteins for transcr[r] ...
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<p>Effect of umbelliferone on adjuvant-induced arthritis in rats by MAPK/NF-κB pathway</p>
... After the rats were euthanized, the synovium of knee joints was isolated and cut into pieces. The samples were snap frozen in liquid nitrogen, homogenized, and lysed in ice-cold RIPA buffer (0.1% phenylmethylsulfonyl ...
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<p>Salidroside Alleviates Cartilage Degeneration Through NF-κB Pathway in Osteoarthritis Rats</p>
... ATDC5 cell damage. 20,21 According to reports, Sal had an inhibitory effect on IL-1 β -induced OA in fl ammation by inhibiting the activation of the NF- κ B pathway in vitro. 21 Similarly, this study found ...
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Hypoxia-induced neutrophil survival is mediated by HIF-1 alpha-dependent NF-kappa B activity
... A further and major regulator of neutrophil function is the ability of these cells to undergo constitutive apoptosis (19). This event triggers the phagocytosis and clearance of apoptotic neutrophils by local macrophages ...
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<p>TRIM31 promotes glioma proliferation and invasion through activating NF-κB pathway</p>
... for NF- κ B pathway activation, Western blot assay suggested that TRIM31 overexpression increased the nuclear translocation of p65 and the phosphorylation of I κ B α , and TRIM31 knockdown inhibited ...
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<p>miR-423 Promotes Breast Cancer Invasion by Activating NF-κB Signaling</p>
... the NF- κ B pathway, to further investigate the role of miR-423 in breast cancer malignancy, gene set enrichment analysis (GSEA) of the TCGA BRCA cohort was performed and showed that higher miR-423 levels ...
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CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF kappa B activation pathways
... potent NF-"B-inhibitory activ- ...antagonize NF-"B activation signals initiated by a variety of receptors or their ...antagonizes NF-"B activation, a role F IG ...
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