NFκB signaling
Transcriptional activation of USP16 gene expression by NFκB signaling
... NFκB signaling regulates USP16 gene transcription by interacting with these putative NFκB cis -acting elements, the effects of NFκB overexpression on the promoter ac- tivity of the 1793 bp ...
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GRO-α and IL-8 enhance ovarian cancer metastatic potential via the CXCR2-mediated TAK1/NFκB signaling cascade
... TGF-β signaling is initiated in cancer metastasis, indicating that this signaling is one of the potential therapeutic targets for combating ovarian cancer peritoneal metastases ...activating NFκB ...
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Identification of Novel Focal Adhesion Kinase Substrates: Role for FAK in NFκB Signaling
... major signaling molecule which functions downstream of integrins or in conjunction with mitogenic signaling ...regulate signaling through its scaffolding activities, FAK encodes an intrinsic kinase ...
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(+)-JQ1 attenuated LPS-induced microglial inflammation via MAPK/NFκB signaling
... signaling via MAPK but not PI3 K signaling. The MAPK pathways consist of a family of highly conserved serine/ threonine protein kinases that are believed to act as the regulators of key cellular processes ...
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A functional map of NFκB signaling identifies novel modulators and multiple system controls
... The NFκB transcription factor represents a collection of dimeric complexes from the NFκB/Rel ...the NFκB signaling pathway is a branched struc- ture with a variety of inputs that include ...
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Elevated NIBP/TRAPPC9 mediates tumorigenesis of cancer cells through NFκB signaling
... of NFκB signaling components, particularly the IKK complex, is present in cancer cells but not in normal cells, suggesting the important role of NFκB and IKK in regulating tumorigenesis [4, 5, ...of ...
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NFκB signaling drives pro-granulocytic astroglial responses to neuromyelitis optica patient IgG
... canonical NFκB-dependent and NFκB-associated tran- scription factors ...tive NFκB signaling pathway, was strongly upregulated, suggesting that multiple NFκB pathways may be in- volved ...
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Nalbuphine suppresses breast cancer stem-like properties and epithelial-mesenchymal transition via the AKT-NFκB signaling pathway
... of life [28]. Adjuvant analgesics are given as part of the therapeutic strategy [29, 30], but some reports showed that opioid analgesics like morphine can contribute to tumor progression [5, 24, 31]. In this study, we ...
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Activated microglia/macrophage whey acidic protein (AMWAP) inhibits NFκB signaling and induces a neuroprotective phenotype in microglia
... BV-2 cells were seeded on glass cover slips and incu- bated with 10 μg/ml fluorescently labeled AMWAP or vehicle for different time spans prior to stimulation with 50 ng/ml LPS for 1 h. Cells were then fixed with 4% for- ...
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The small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cells
... Our data suggest that NF-κB activity in HEK293 cells is inhibited by NSC676914A at low concentrations; however this effect is not its primary mechanism of toxicity, as IKKβ inhibition alone is less toxic to the cells. In ...
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The anti-inflammatory effects of the tellurium redox modulating compound, AS101, are associated with regulation of NFκB signaling pathway and nitric oxide induction in macrophages
... Cells were suspended with ice-cold lysis buffer contain- ing 50 mM Tris(pH 7.5), 150 mM NaCl, 10% glycerol, 1% TritonX, 1 mM EDTA, 1 mM PMSF, 0.4 mM sodium vanadate, 5 mg/ml aprotinin, and 5 mg/ml leu- peptin for 15 min ...
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The NFκB pathway: a therapeutic target in glioblastoma
... the NFκB signaling pathway, many studies demonstrated the association between upregulated activity of NFκB and cancer, mostly by protecting tumor cells from ...the NFκB pathway by using a ...
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Bortezomib enhances expression of effector molecules in anti- tumor CD8 T lymphocytes by promoting Notch-nuclear factor- κB crosstalk
... Notch signaling can thus lead to several hematological diseases ...Notch signaling is triggered by receptor-ligand interactions between juxtaposed neighboring ...facilitating NFκB retention in the ...
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Overcoming adaptive resistance in mucoepidermoid carcinoma through inhibition of the IKK-β/IκBα/NFκB axis
... upregulate NFκB binding activity in several types of solid tumors in a dose- and time-dependent manner [13, 20, ...of NFκB in tumor cells is an important determinant of responsiveness to IR because ...
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Acute Inflammatory Response Following Increased Blood-Brain Barrier Permeability Induced by Focused Ultrasound is Dependent on Microbubble Dose
... qPCR Master Mix (Qiagen, Hilden, Germany) was used in conjunction with CFX96 Touch Real-Time PCR Detection System (Bio-Rad Laboratories, Inc., Hercules, CA, USA) for quantitative real-time polymerase chain reaction ...
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Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NFκB-TLR signaling pathway
... receptor signaling pathway PCR array (see the Gene list at Table ...cluding NFκB, JNK, and p38 signaling, were actually acti- vated in ...the signaling events triggered by exosomes through ...
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Upregulation of human PINK1 gene expression by NFκB signalling
... of NFκB signaling. Thus, the increase of PINK1 ex- pression by NFκB activation could be ...of NFκB in dopaminergic neurons of PD patients is a reflection of the apoptotic and inflammatory ...
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Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network
... Cell Signaling Technology (Danvers, ...Cell Signaling Technology) was used as loading control for the nuclear fraction, β-actin or α-tubulin for cytoplasm, and β-actin for total ...(Cell Signaling ...
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Dysregulated apoptosis and NFκB expression in COPD subjects
... in NFκB induction and activation may be due to the presence of high levels of cytokines which prolong the lifespan of the neutrophil ...activate NFκB and induce expression of NFκB-regulated genes ...
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Walterinnesia aegyptia venom combined with silica nanoparticles enhances the functioning of normal lymphocytes through PI3K/AKT, NFκB and ERK signaling
... glycerol, and 280 mM 2-ME) and separated using discon- tinuous SDS-PAGE. Proteins were transferred onto nitro- cellulose membranes using a Bio-Rad Trans-Blot electrophoretic transfer device, and the membranes were ...
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