Nitric Oxide and Insulin
Induction of insulin secretion in engineered liver cells by nitric oxide
... Although insulin secretion from these engineered cells is not very responsive to changes in glucose levels, addi- tion of L-arginine stimulates insulin secretion up to 3-fold via the nitric ...
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Role of TAB1 in nitric oxide-induced p38 activation in insulin-producing cells
... in nitric oxide-induced activation of p38 ...in insulin-producing β-TC6 ...promotes nitric oxide-induced p38 autophosphorylation. In addition, nitric oxide-induced p38 ...
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Arterial stiffness in insulin resistance: The role of nitric oxide and angiotensin II receptors
... stiffness, insulin resistance, nitric oxide, AT1 receptor, AT2 receptor, diabetes, insulin resistance, obesity Introduction Insulin resistance (INSR) is a metabolic abnormality ...
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Insulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathy
... neuronal nitric oxide synthase gene ...by insulin treatment. Thus diabetic gastropathy in mice reflects an insulin-sensitive reversible loss of ...
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Insulin stimulated production of nitric oxide is inhibited by wortmannin Direct measurement in vascular endothelial cells
... the insulin recep- tor in various ...of insulin action in vascular ...hypertension-associated insulin resistant states such as diabetes and ...that insulin stimulates production of NO from en- ...
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Insulin modulation of an endothelial nitric oxide component present in the alpha2 and beta adrenergic responses in human forearm
... of nitric oxide. Insulin is likely able to sensitize this en- dothelial pathway modifying the overall vascular response evoked by a 2 and b-adrenergic ...by insulin may be also the result of ...
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Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin dependent diabetes
... with insulin-dependent diabetes mellitus have an increased mortality and morbidity due to vascular ...complications. Nitric oxide from the vascular endothelium contributes to the control of normal ...
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Insulin mediated skeletal muscle vasodilation is nitric oxide dependent A novel action of insulin to increase nitric oxide release
... To investigate whether insulin modulates the vascular re- sponse to EDNO, SNP, which acts as exogenous NO donor and directly dilates smooth vascular muscle (endothelium-independent vasod[r] ...
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Central nervous system nitric oxide synthase activity regulates insulin secretion and insulin action
... -NMMA–induced insulin resistance is coincident with the on- set of hypertension (14), and thus, one could speculate that in- sulin resistance is etiologically related to hypertension in this ...that insulin ...
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Nitric oxide is required for the insulin sensitizing effects of contraction in mouse skeletal muscle
... The effect of serum exposure during ex vivo contraction on mouse skeletal muscle 254.. insulin sensitivity 3.5 hrs post-contraction 255.[r] ...
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The Insulin-like Growth Factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium.
... siRNA-mediated downregulation of IGF-1R in human umbilical vein ECs. The following validated oligonucleotides were synthesized from Sigma- Aldrich (SASI_Hs01_00126194 HUMAN NM_000875). Human umbilical vein endothelial ...
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Nitric oxide and cardiovascular effects: new insights in the role of nitric oxide for the management of osteoarthritis
... cytes from normal cartilage. Therefore, NO generated by constitutive NOS enzymes may have beneficial effects such as improved blood flow through vasodilatation, but under different circumstances, at higher concentrations ...
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The Roles of Nitric Oxide Synthase/Nitric Oxide Pathway in the Pathology of Vascular Dementia and Related Therapeutic Approaches
... on insulin resistance, endothelial dysfunction markers and inflammation in mice with high‐fat and high‐fructose ...Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L‐arginine ...
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Nitric oxide synthase and the contribution of nitric oxide to vertebrate motor control
... 2003). Nitric oxide has been implicated as a metamodulator of locomotion and may play a part in the development of amphibian motor systems and their maturation (see McLean et ...
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Is Nitric Oxide a Hormone?
... appraisal of the Griess reaction in the L-arginine/nitric oxide area of research. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 851: 51-70. 33. Wennmalm, A., Benthin, G., Edlund, A., Jungersten, L., ...
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Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides
... histochemical studies of RA synovium with antiserum against iNOS revealed that iNOS protein was strongly expressed in synovial lining cells, endothelial cells, and, to a lesser extent, i[r] ...
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Nitric Oxide-Dependent Penile Erection in Mice Lacking Neuronal Nitric Oxide Synthase
... In cross sections of the proximal penis of the wild-type (A) and nNOS- mouse (B), staining of dorsal penile nerves (arrow) is observed only in the wild-type penis. Counterstaining with h[r] ...
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Hypergravity upregulates renal inducible nitric oxide synthase expression and nitric oxide production
... dysfunction. Nitric oxide (NO), which is endogenously synthesized by inducible NO synthase (iNOS), plays an important role in the regulation of renal ...
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Exhaled nitric oxide and inducible nitric oxide synthase gene polymorphism in Japanese asthmatics
... nitric oxide synthase. 4 In addition, inducible nitric oxide synthase (iNOS) is activated by in flammatory cytokines, and iNOS activity in bronchial epithelial cells is a major determinant of ...
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Nitric oxide for cancer therapy
... of nitric oxide resulted in cytostatic and cytotoxic activity of target ...of nitric oxide in cancer ...NO: Nitric oxide; PDE: Phosphodiesterase; PKA: Protein kinase A; PKG: ...
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