Nitric oxide and its biological function
Vascular nitric oxide: formation and function
... Nitrovasodilators have long been used in clinical settings to treat angina pectoris. Even though the physiological effects of nitrate administration is undeniably beneficial, the mecha- nisms through which it exerts ...
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Effect of (nitric oxide) NO donors on cardiac function
... The positive response of papillary muscles to DEANO suggests that with a fast NO donor and a background of isoprenaline the papillary muscle behaves similarly to isolated myocytes. The negative effect with GSNO reflects ...
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Nitric Oxide and Peroxynitrite: Effects on Cardiovascular Function
... Both nitric oxide and peroxynitrite have been implicated in different cardiovascular ...processes. Nitric oxide is an endogenous vasodilator and mediator of several important physiological ...
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Molecular structure and function of bacterial nitric oxide reductase
... membrane-integrated nitric oxide reductase cNOR from Pseudomonas aeruginosa was ...to function as a structural factor in maintaining a protein conformation that is suitable for electron-coupled ...
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Detection and quantification of nitric oxide-derived oxidants in biological systems
... in biological systems through direct spectroscopic ...particular biological context are based either on the measurement of downstream stable products or on the use of probes that react with the ...using ...
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Studies on Nitric Oxide Generation and its Enzymatic Degradation
... HDX-MS experiments are capable of investigating protein-substrate interactions. One method of doing so includes utilizing microfluidic set ups in order to perform consistent and reproducible experiments. An example of ...
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C-786T (Promoter) Allelic Variants of Nitric Oxide Synthase Gene and Its Association with Nitric Oxide in Preeclampsia
... 15 SPLICE FORMS AS NOVEL GENETIC REGULATORS OF sGC: Recently, the necessary importance of sGC for mammalian physiology was directly confirmed by generation of sGC knockout mice 45 . The absence sGC protein resulted in a ...
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The biosynthesis of nitric oxide from L-arginine. Nitric oxide formation features and its functional role in mitochondria
... dothelium, nitric oxide diffuses to smooth muscle syncytia, activating sGC in myocytes and nitrosyla- ting target ...with nitric oxide activates the mentioned ...
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Nitric Oxide in Skeletal Muscle: Role on Mitochondrial Biogenesis and Function
... S-glutathionylation induces a reversible uncoupling of eNOS, which during oxidative stress, could function to prevent irreversible oxidative damage of the thiols critical for eNOS function [76]. ...
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Nitric oxide synthase and the contribution of nitric oxide to vertebrate motor control
... i.e. under‐fixed, or fixing was delayed too long, which would allow enzymatic degradation (Werner et al., 2000). 5.4 Other considerations NADPH‐d and nNOS immunohistochemistry provide some interesting information ...
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Structure-Function Changes of the Distal Outflow Tract in Response to Nitric Oxide
... Consistent with our prior experience, 21,23,24,34,41,42 the perfused porcine anterior segments did not experience the amount of corneal edema reported with other culture techniques. 43 With intact TM, nitric ...
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Nitric oxide unravels the enigmatic function of the paranasal sinuses: a review of literature
... Nitric oxide concentrations in the lower airways of tra- cheostomized and intubated patients are as low as 2–4 ppb [ 22 ], while a concentration in the range of 22,300– 29,000 ppb has been detected in the ...
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Surfactant Function and Composition in Premature Infants Treated With Inhaled Nitric Oxide
... Tracheal aspirate samples were collected from 99 infants, and data on surfactant composition and/or function were available for 83 patients with both a baseline sam- ple and ⱖ 1 postentry sample. Reasons for ...
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Is Nitric Oxide a Hormone?
... limits its transport to distant organs [31, 99]; therefore, it has been suggested that nitrite [32, 99-102] and/or S- nitrosothiol [32, 97, 103-105] are responsible for intravascular transport of ...
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The nitric oxide/superoxide assay Insights into the biological chemistry of the NO/O 2 interaction
... The computer model developed from know rate constants allows the simulation of the reaction of both radicals with oxyHb and ferricytochrome c. From these results, insight is gained into the important role of redox-active ...
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Nitric oxide: Its generation and interactions with other reactive signaling compounds
... to function in a manner similar to a mammalian one, it should have a reductase domain capable of oxidizing NAPDH and having a flavin prosthetic group, such as flavin mononucleotide ...
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Alveolar nitric oxide and its role in pediatric asthma control assessment
... CA NO and lower FEV 1 . A possible explanation could lie in differences in the populations selected for study. Our cohort of asthmatic (treated and untreated) patients was, in general, a group with mild, well-controlled ...
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Physiological Roles of Nitric Oxide and Protein Disulfide Isomerase Relevant to Vascular Function
... In extention of the cholesterol studies, we also investigated the effect of platelet cholesterol on anti-thrombotic drug (AZD6140) mediated inhibition of P2Y12 sign[r] ...
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Cytokines suppress human islet function irrespective of their effects on nitric oxide generation
... preparations. The present study examined whether exposure of human pancreatic islets to different cytokines induces NO and impairs beta-cell function. Islets from 30 human pancreata were exposed for 6-144 h to the ...
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Lung function and fractional exhaled nitric oxide among petroleum refinery workers
... In the present study, we found a significant decrease in lung function parameters including FEV1, PEF, FEV1/ FVC %, FEF-25 % and FEF-50 % in petroleum oil re- finery workers compared to their matched control ...
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