NKT cell
Type II NKT cell–mediated anergy induction in type I NKT cells prevents inflammatory liver disease
... among NKT cell subsets medi- ated by a physiologically relevant self-lipid antigen that can be used to inhibit type I responses and ultimately disease ...
12
Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice
... of NKT cells render this subset of lipid-specific T cells a promising target for immunotherapeutic ...typic NKT cell agonist, which elicits this function when bound to ...of NKT cell ...
13
NKT cell–dependent leukemia eradication following stem cell mobilization with potent G CSF analogs
... enhances NKT cell responses to TCR ligation and increases GVL ...stem cell mobilization with G-CSF is dose dependent and may also be enhanced via the augmentation of G-CSF activ- ity by pegylation ...
12
Does an NKT-cell-based immunotherapeutic approach have a future in multiple myeloma?
... I NKT cells is often reduced. Therefore, the effects of NKT activation may be less amplified in humans than in mice ...I NKT cells cannot be restimulated for at least two months ...an ...
13
Testing the NKT cell hypothesis of human IDDM pathogenesis
... of NKT cells in autoimmune ...the NKT cell defect through overexpression or cell transfer (16, ...the NKT defect by introduction of a germline deletion of CD1d led to an exacerbation of ...
9
Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity
... , NKT cells and required T-bet and TLR7. Adoptive transfer of this cell population into allergen- sensitized adult mice suppressed the development of allergen-induced AHR, an effect associated with ...
14
NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human
... Over the past decade, certain mAbs have been shown to provide an effective approach to treat hematological malignancies, and the anti-CD122 mAb (against IL-2/15Rβ) is one of the mAbs being studied in clinic for the ...
16
Histone demethylases UTX and JMJD3 are required for NKT cell development in mice
... liver NKT cells, while conventional T cells are less affected. Loss of NKT cells is cell intrinsic and not due to an insufficient selection ...of NKT cells in UTX/JMJD3-deficient mice protects ...
14
TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury
... Our study raises several interesting questions that warrant further investigation. Clearly, the underlying mechanisms that induce iNKT cells to constitutively express OX40 and caspase 1 remain unknown. One possibility is ...
14
IL 10–producing NKT10 cells are a distinct regulatory invariant NKT cell subset
... NK cell trans-activation, induced in part by iNKT cell–derived IFN-γ (18, ...B16-CD1d cell line to directly address whether αGalCer-pretreated iNKT cells could protect mice against this ...
17
NK and NKT Cell-Independent Contribution of Interleukin-15 to Innate Protection against Mucosal Viral Infection
... Overall, our results indicate that IL-15 plays an important role in innate protection against HSV-2. Cells from the genital mucosa and RAW264.7 cells produce significant amounts of IL-15 in response to HSV-2 infection. ...
9
1 The Janus Face of NKT Cell Function in
... anti-inflammatory functions of different subsets of CD1d-restricted natural killer T cells during 369. Trypanosoma cruzi infection[r] ...
11
Comparison between interleukine-17 levels by NK-T cells in patients with chronic hepatitis C and healthy individuals
... studies, NKT cells activates by α- GalCer that has been shown to induce rapidly NKT cell activation and enhance the anti- tumor activity of NKT cells (22, ...23). NKT cells are shown to ...
6
Oncogene MYCN regulates localization of NKT cells to the site of disease in neuroblastoma
... T cell and monocyte numbers in MYCN-amplified versus nonamplified BM metastases in ...the NKT subset, so that the effect of tumor-derived chemokines on T cell frequency in BM could be nullified by ...
12
Click here to download PDF version of the article !
... The NKT cell is a CD3 + T cell, having one or more markers of the NK cell ...This cell type resides predominantly in the liver and responds solely to antigen presentation mediated by ...
7
Scavenger receptors target glycolipids for natural killer T cell activation
... T cell immunity (3, 5). NKT cells represent a special- ized subset of innate-like T lymphocytes that recognize glycolipid antigens presented by CD1d ...(6–8). NKT cells have gained par- ticular ...
13
FcγRIII engagement provides activating signals to NKT cells in antibody induced joint inflammation
... on NKT cells, we compared the relative strengths of the activating signals from TCR and FcgRIII on NKT cells by measuring cytokine production after stimulating liver MNCs of B6 mice with anti-CD3 mAb or ...
10
OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice
... the NKT cell activation (7, 11, ...Cer–stimulated NKT cells triggers DC maturation through the CD40 engagement, offering DCs the potential to secrete IL-12 that in turn affects IFN-γ production of ...
10
IL 15 protects NKT cells from inhibition by tumor associated macrophages and enhances antimetastatic activity
... for NKT cell in vitro migration toward a coculture of NB cells with monocytes in normoxic and hypoxic ...for NKT cell migration in normoxia, CCL20 was largely responsible for their migration ...
14
Highly Purified Mycobacterial Phosphatidylinositol Mannosides Drive Cell-Mediated Responses and Activate NKT Cells in Cattle
... of NKT cells in cattle has been a controversial issue ...T cell (CD3) and NK cell (NKp46) markers, suggesting the presence of an NKT cell population in bovine peripheral blood ...bovine ...
8